- Research Article
- 10.1016/j.leukres.2025.107878
OUTCOME RESEARCH (INCLUDING QUALITY OF LIFE) AND HEALTH ECONOMICS - PATIENT-REPORTED OUTCOMES & QUALITY OF LIFE
- Sep 01, 2025
- Leukemia Research
- Ines Vaide + 2 more +2
Publications from 2021 to 2026
Showing 10 of 15 papers
OUTCOME RESEARCH (INCLUDING QUALITY OF LIFE) AND HEALTH ECONOMICS - PATIENT-REPORTED OUTCOMES & QUALITY OF LIFE
Prevention of haemostatic complications Myeloproliferative Neoplasms: retrospective mutational and haemostatic profile study in Western Estonia
Introduction Patients with myeloproliferative neoplasms (MN) have the complication in both side of hemostasis – related to bleeding and thrombosis. The major goal of therapy is to reduce thrombosis risk, which impacts MN morbidity and mortality. However, in lifelong evaluating quality of life during the disease course, the bleeding has also important role. Acquired von Willebrand disease (AvWD) may result from increased proteolysis together with platelet activation, which leads to reduced von Willebrand factor activity (vWFact). Holding hemostatic balance in prophylactical management to prevent complications is challenging, and understanding predicting factors valuable for physician. Approximately 60% of patients with MN carry a genetic mutation: it's suggested that in MPN thrombocytosis has a higher risk of bleeding than thrombosis, aspirin may exacerbate this risk of bleeding in CALR-mutated essential thrombocythemia (ET) and JAK2 V617F mutation increases risk of thrombotic complications. We analyzed our MN patient cohort to lab analysis related to hemostasis and genetic testing in order to have better understanding in the patient's profile [1] [2] [3].
Read moreEsports and Future
Co-creation as a Service Design Tool for Improving Hospital Services: The Example of Pärnu Hospital's Patient Advisory Council, Estonia
The most important mission of healthcare organizations is to create values for patients by achieving the best treatment outcomes and taking maximum account of the needs and specificities of the patients. The healthcare service provider should not be the only value creator, and service receivers could also co-create the service value with the service provider. The co-creation principle of service design states that to design or improve the experience of a service, it is important to involve all its actors. Co-creating with patients means engaging them actively in the design process. Patients can be involved in co-creation in a wide variety of ways, e.g. mapping patients’ journeys, providing feedback on the different stages of the care pathway, asking for information on the sufficiency and clarity of the information that is important to them, organizing workshops, roundtables, etc. The involvement of patients in co-creation processes is essential in order to better understand their expectations, experiences, behaviours, and feelings. One of the opportunities for co-creation in obtaining a patient view has become the patient advisory councils (PAC) established at hospitals. As of today, PACs have been established in five Estonian hospitals. Although the formation and work processes in the councils differ, the input of PACs to hospitals so far has been similar: proposals on the adequacy and availability of information to be shared with patients, the creation of patient support services (e.g. patient schools and discussion groups), improving hospitals’ physical environment, and participating in different projects with a patient view. The chapter gives an example of the experience of Pärnu Hospital’s Patient Advisory Council as a partner in the co-creation of hospital service design.
Read moreMoney Matters: Financial Planning
Esports—The Most Passionate Segment of Gaming
The relative importance of culture in urban tourism: implications for segmentation
PurposeThis paper aims to contribute to urban tourism segmentation studies by examining the role of culture as a motivation for city visits, different preferences for activities and the demographic factors that influence activity choices. This study also compares the memorability of the trip across the segments identified based on their undertaken activities.Design/methodology/approachThis paper draws on questionnaire data that was collected from 614 tourists in Budapest, Hungary. Tourist segmentation was based on a two-step procedure: principal component analysis and Hierarchical Cluster Analysis. Multinomial logistic regression was applied to reveal the effect of different demographic and travel-related characteristics on the segments.FindingsThe research revealed that cultural activities are still the most important motivation for urban tourists and that cultural tourists constitute the biggest segment (43%). They show a preference for heritage sites, museums and galleries rather than performing arts and festivals. Multinomial logistic regression showed that party tourists can be differentiated from cultural tourists and city break tourists predominantly by age and travel status. Older age groups and women are more likely to be interested in heritage sites, museums and galleries. Party tourists found their experience significantly more memorable than any other group and were much more likely to re-visit and recommend.Research limitations/implicationsOverall, this study provides useful information for destination management organisations and city agencies about which activities to promote and how to segment and potentially target tourists. This study did not include lifestyle and personality factors, secondary and complementary attractions or cultural proximity and distance.Originality/valueThere have been relatively few recent studies on urban cultural tourism segmentation, especially in whole destinations rather than at individual attractions, it was therefore considered timely to re-visit this area of research. This paper reinforces the importance of segmentation studies in tourism and analyses the changing motivations and activity preferences of urban cultural tourists over time.
Read moreThe Baltic Health Index (BHI): Assessing the social–ecological status of the Baltic Sea
Abstract Improving the health of coastal and open sea marine ecosystems represents a substantial challenge for sustainable marine resource management, since it requires balancing human benefits and impacts on the ocean. This challenge is often exacerbated by incomplete knowledge and lack of tools that measure ocean and coastal ecosystem health in a way that allows consistent monitoring of progress towards predefined management targets. The lack of such tools often limits capabilities to enact and enforce effective governance. We introduce the Baltic Health Index (BHI) as a transparent, collaborative and repeatable assessment tool. The Index complements existing, more ecological‐oriented, approaches by including a human dimension on the status of the Baltic Sea, an ecosystem impacted by multiple anthropogenic pressures and governed by a multitude of comprehensive national and international policies. Using a large amount of social–ecological data available, we assessed the health of the Baltic Sea for nine goals that represent the status towards set targets, for example, clean waters, biodiversity, food provision, natural products extraction and tourism. Our results indicate that the overall health of the Baltic Sea is suboptimal (a score of 76 out of 100), and a substantial effort is required to reach the management objectives and associated targets. Subregionally, the lowest BHI scores were measured for carbon storage, contaminants and lasting special places (i.e. marine protected areas), albeit with large spatial variation. Overall, the likely future status of all goals in the BHI averaged for the entire Baltic Sea is better than the present status, indicating a positive trend towards a healthier Baltic Sea. However, in some Baltic Sea basins, the trend for specific goals was decreasing, highlighting locations and issues that should be the focus of management priorities. The BHI outcomes can be used to identify both pan‐Baltic and subregional scale management priorities and to illustrate the interconnectedness between goals linked by cumulative pressures. Hence, the information provided by the BHI tool and its further development will contribute towards the fulfilment of the UN Agenda 2030 and its Sustainability Development Goals. A free Plain Language Summary can be found within the Supporting Information of this article.
Read moreRural Tourism as a Tool for Sustainable Development: Lessons Learned in Estonia
Changes in Livonian first names in Salaca during the 17th and 18th centuries
Under examination are the developments that occurred in name traditions that were caused by Christianisation as can be ascertained on the basis of written sources. The area under examination is the Livonian revenue district which was defined in the 17th century, and which, by the end of the century, comprised the Svētciems Manor. The first names of the peasants identified as Livonians in the first half of the 19th century were compared to the first names of the farmers recorded in the soul revisions from the 17th century. As a result, the article ascertains that the custom of having two first names had disappeared by the 17th century. In the 18th century, a new name – Gust/Gustav – had been added to the name tradition in the region. By the turn of the 19th century, after six centuries of integration under colonial rule, the Christian names of the Livonians, Latvians, and Estonians were so similar that it was difficult to distinguish among them based on their first names. Various local versions of Western European Christian names were overwhelmingly in use.Kokkuvõte. Aldur Vunk: Muutused liivlaste eesnimedes Salatsi piirkonnas 17. ja 18. sajandil. Otsest survet pühakunimede valimisel, nagu oli tavaks idakirikus, läänekirik ei tundnud. Siiski oli ristinimede valikus ka uusajal enamus apostlite ja pühakute nimesid. Liivi vakuse talupoegade 44 eesnimest olid 1624. aasta revisjoni põhjal selliseid nimesid 31: Marten (4), Tomas/Tohmas (4), Matz/Matzken (4), Hanß (4), Hans (3), Jan/Jans (3), Andres/Andreas (3), Jürgen/Jür (3), Jak/Jack (2) ja Peter. Kui siia lisada veel Grist Hanß (3), oli apostlite ja pühakute nimesid eesnimedest 70%. Sama tüüpi eesnimed olid valitsevad ka 60 aastat hiljem, kui Svētciems’i mõisa 40 peremehe eesnimedest olid 31 tuletatud apostlite ja pühakute nimedest: Hans (5), Andrus/Andres (5), Jack (5), Jörgen (4), Mats (3), Tohm (2), Jahn (2), Jüri (2), Juhan, Tönnis ja Marten. Ebajärjekindlus nimede kirjaviisides 17.–19. sajandil ei võimalda teha detailseid järeldusi, kuid nimevormide Hanß ja Hans esinemise järgi juba 1624. aasta revisjonikirjetes võib tõmmata paralleeli 19. sajandi alguses kasutuses olnud nimevormidega Anz, Ansche ja Ange. Huvitav on veel 17. sajandi esimesel poolel eksisteerinud kahe eesnime panemise komme, eriti nimepaari esimene nimi, milleks järjekindlalt oli Grist. Selle kombe tagamaid on ühe allika põhjal raske välja selgitada ja võib vaid oletada, et tegemist on katoliku aja traditsiooniga. Usupuhastusliikumise vastuoludele, mis veel 17. sajandil oli olulise tähendusega, võib osundada ka tunduvalt vähemat kasutust leidnud eesnimi Pape/Poope. Kokkuvõttes on 17. sajandist kuni 19. sajandini eesnimede traditsiooni muutuste taga küllalt sageli näha poliitilisi ja ühiskondlikke arenguid. Nimetraditsioon ei jäänud juba keskajal lokaalseks nähtuseks ja oli vägagi sarnane ülejäänud kristliku ruumiga. Samuti väljendusid selles reformatsiooniajastu vastuolud ja võimalik, et koguni oma vaadete manifesteerimine. Nähtavasti jättis talupoeglik nimetraditsioon lisaks järjepidevusele selles koha ka poolehoiuavaldustele headele isandatele või mõjukatele ristivanematele.Märksõnad: Liivimaa, Salatsi liivlased, ajalooline onomastika, eesnimedKubbõvõttõks. Aldur Vunk: Mõitõkst līvlizt eḑḑiztnimīs Salāts immõrkouțš 17. ja 18. āigastsadā āigal Vežgõrpivākuodā iz tund kūoḑizt painõ lõvvõ pivālizt nimīdi nei kui se um irdõksõks mǭgõr pivākuodās. Sīegid vȯļtõ ka ūdāiga rištõbnimūd ulzvȯtštõbs jemmit vȯļțõ apostõld ja pivālizt nimūd. Līvõ vakā talūd 44 eḑīznimstõ vȯļtõ seļļizt 1624. āigast revīzij pierrõ 31: Marten (4), Tomas/Tohmas (4), Matz/Matzken (4), Hanß (4), Hans (3), Jan/Jans (3), Andres/Andreas (3), Jürgen/Jür (3), Jak/Jack (2) ja Peter. Ku näntõn jūrõ pānda vel Grist Hanß (3), vȯļ apostõld ja pivālizt nimīdi eḑḑiztnimūd siegās 70%. Siedā īž tīpõ eḑḑiztnimūd vȯļtõ jemmits vel 60 āigastõ obbõm, ku Pivākilā mȯizõ 40 perīmīe eḑḑiznimīst 31 vȯļtõ sǭdõd apostõld ja pivālizt nimīst: Hans (5), Andrus/Andres (5), Jack (5), Jörgen (4), Mats (3), Tohm (2), Jahn (2), Jüri (2), Juhan, Tönnis ja Marten. Nimūd kēravīț äbpīldzit 17.–19. āigastsadāl äb lask tīedõ pīenõstiz pierāldõkši, umīțigid võib 1624. āigast revīzijkēraltõkst nimūdõn Hanß ja Hans vieddõ paralēlõ 19. āigastsadā īrgandõks nimūdõks Anz, Ansche ja Ange. Interesant um vel 17, āigastsadā ežmis pūols vȯnd kǭd edḑīznim panmiz mūoḑ, ī’žkiz nimūdpǭr ežmi nim, mis pīldzist vȯļ Grist. Sīe mūod pūojõ īdāinagiz ovāt alīz pǟl um lǟlam seļțõ, võib set vȱldatõ ku se um katol āiga irdõks. Uskpūdistimizlikkimiz vastālitõn, mis vel 17. āigastsadā āigal vȯļ vȯldzi, võib vīțõ ka veitõm kȭlbatõd eḑḑinim Pape/ Poope. Amāleb võib 17. –19. āigastsadā āiga eḑḑiztnimūd irdõks mõitõkst tagān saggõld nǟdõ polītiliži ja kubgõn kazāndõkši. Nimūdirdõks iz ūo jõbā sidāmtāigal kūožli nǟdõks, se vȯļ jõvāgid īti mū kristliz īlmaks. Neiīž saitõ sīes spīegiļtõd reformātsij āiga vastõvȯlmizt ja võib vȱlda īž ka eņtš nēmizt nägțimi. Silmõznǟdsõ vȯļ talrov nimūdirdõksõs andtõd kūož ka pūolõpidāmizt pierāst jõvād izāndõdõn agā mȯjjizt rištvanbiztõn.
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