Pacific Antenna Systems (United States)

Abstract A very high‐spatial resolution (∼21–23 m pixel at 85 km altitude) OH airglow imager at the Andes Lidar Observatory at Cerro Pachón, Chile observed considerable ducted wave activity on the night of 29–30 October 2016. This instrument was collocated with a Na wind‐temperature lidar that provided data revealing the occurrence of strong ducts. A large field of view OH and greenline airglow imager showed waves present over a vertical extent consistent with the altitudes of the ducting features identified in the lidar profiles. While waves that appeared to be ducted were seen in all imagers throughout the observation interval, the wave train seen in the OH images at earlier times had a distinct leading nonsinusoidal phase followed by several, lower‐amplitude, more sinusoidal phases, suggesting a likely bore. The leading phase exhibited significant dissipation via small‐scale secondary instabilities suggesting vortex rings that progressed rapidly to smaller scales and turbulence (the latter not fully resolved) thereafter. The motions of these small‐scale features were consistent with their location in the duct at or below ∼83–84 km. Bore dissipation caused a momentum flux divergence and a local acceleration of the mean flow within the duct along the direction of the initial bore propagation. A number of these features are consistent with mesospheric bores observed or modeled in previous studies.

PSSFSS is a free, open-source code for analysis and design of polarization selective surfaces (PSSs), frequency selective surfaces (FSSs), radomes, reflectarray elements, and similar devices. It is written in Julia, a recently developed language for high-performance technical computing. Its speed and ease of use make PSSFSS useful and accessible to both students and working engineers. This paper describes the design of PSSFSS and provides several examples of its use, with comparisons to results from other simulation tools.

Abstract Translation of the unprecedented efficacy of chimeric antigen receptor (CAR) T-cell technology into solid tumors requires a solution to the problem of on-target damage of vital organs. We have developed an inhibitory CAR platform (iCAR) that imposes self-regulation in CAR T-cells to restrict inappropriate activation against normal cells without compromising tumor efficacy. The system consists of an iCAR that is co-expressed with a conventional activating CAR (aCAR) designed to activate T-cells. The iCAR and aCAR scFvs bind distinct cell-surface antigens that are ubiquitously expressed across all solid tumor histologies and normal tissues. The iCAR is allele-specific whereas the aCAR is pan-allelic. The iCAR technology was validated in functional assays and NSG models with cancer cell lines that mimic loss-of-heterozygosity (LOH) which is common in most human cancers due to increased chromosomal instability. In this context, loss of iCAR target expression due to LOH generates irreversible target specificity. Tumor-specific overexpression of aCAR and iCAR targets, a common barrier to the clinical translation of potent agents targeting the cell-surface proteins is not required. We have shown using in vitro and in vivo models that CAR T-cell activation and target killing are fully inhibited by dual iCAR + aCAR antigen engagement. This outcome validates the concept of iCAR-mediated protection of normal cells in vital organs. In contrast, tumors that mimic iCAR target LOH through CRISPR editing were fully eradicated with aCAR engagement alone. T-cell activation, proliferation, and cytotoxic activity after exposure to target cells lacking iCAR target antigen was found to be quantitatively indistinguishable from the results obtained with single input aCAR CAR T-cells. These results suggest that iCAR technology can enable treatment of cancer patients with solid tumors using CAR T-cells that maximize potency and efficacy by mitigating on-target CRS, neurotoxicity, and inevitable organ damage. The restriction of CAR T activation to the local tumor environment by iCAR-mediated self-regulation directly addresses a fundamental technology gap that cannot be solved by CAR T dosing or aCAR modification alone. Citation Format: Michael R. Weist, Adi Sharbi-Yunger, Jason Yi, Caitlin Schnair, David Bassan, Tanya Kim, Sarit Tabak, Yael Lopesco, Leehee Weinberger, Nir Bujanover, Neta Chaim, Kristina Vucci, Orit Foord, Frank J. Calzone, Rick Kendall, Gregor B. Adams. Rewiring CAR T-cells for absolute solid tumor specificity and safety [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2826.

Resumo Objetivo: Identificar, na literatura científica, a relação da obesidade como fator de risco agravante para a morbidade por COVID-19. Métodos: Trata-se de um estudo bibliográfico, tipo revisão integrativa de literatura, nos idiomas português, inglês e espanhol, por meio da estratégia PICo, em cinco bases de dados,PubMed, Scopus, Web of Science, Embasee BVS, realizada de maio a junho de 2020. Os critérios de inclusão adotados foram: artigos primários realizados com adultos; disponíveis na íntegra; publicados durante o período de 2019 [...]

El artículo analiza las opiniones de Pitirim Sorokin sobre el concepto y el contenido del comportamiento positivo. Como parte del análisis de este concepto, el autor revela las características de un hecho positivo, la teoría del derecho de adjudicación.

Blue emitting, up-converting NP's of SrTiO3:Tm3+/Yb3+ synthesized using the citric route are biocompatible towards J774.E whereas the cytotoxic effect to U2OS cells is not particle size dependent but most probably is related to Sr2+ ion release.

Lanthanide doped nanoparticles (Ln:NPs) hold promise as novel luminescent probes for numerous applications in nanobiophotonics. Despite excellent photostability, narrowband photoluminescence, efficient anti-Stokes emission and long luminescence lifetimes, which are needed to meet the requirements of multiplexed and background free detection at prolonged observation times, concern about their toxicity is still an issue for both in vivo and in vitro applications. Similar to other chemicals or pharmaceuticals, the very same properties that are desirable and potentially useful from a biomedical perspective can also give rise to unexpected and hazardous toxicities. In engineered bionanomaterials, the potentially harmful effects may originate not only from their chemical composition but also from their small size. The latter property enables the nanoparticles to bypass the biological barriers, thus allowing deep tissue penetration and the accumulation of the nanoparticles in a number of organs. In addition, nanoparticles are known to possess high surface chemical reactivity as well as a large surface-to-volume ratio, which may seriously affect their biocompatibility. Herein we survey the underlying mechanisms of nanotoxicity and provide an overview on the nanotoxicity of lanthanides and of upconverting nanoparticles.

In 2010 the Research Committee for the American Association of Children's Residential Centers (AACRC) embarked upon a project to repeat the survey that was originally sent out in 1999, hoping to learn how agencies have adapted as well as what was new in the residential treatment environment. The committee was interested in population changes, length of stay, diagnosis, gender, and race, and whether there had been changes in sources of funding and services funded. The committee was particularly interested in the role of data collection and analysis, and how agencies use data to improve process and evaluate outcomes. The growth and sustainability of residential treatment as a viable service option may depend upon the field's willingness to track results, partner with families and the youth they serve, and to make themselves accountable to all stakeholders in the children's services system.