Pacific Design Technologies (United States)

The dynamic characteristics of speech signal provides temporal information and play an important role in enhancing Automatic Speech Recognition (ASR). In this work, we characterized the acoustic transitions in a ratio plane of Spectral Subband Centroid Frequencies (SSCFs) using polar parameters to capture the dynamic characteristics of the speech and minimize spectral variation. These dynamic parameters were combined with Mel-Frequency Cepstral Coefficients (MFCCs) in Vietnamese ASR to capture more detailed spectral information. The SSCF0 was used as a pseudo-feature for the fundamental frequency (F0) to describe the tonal information robustly. The findings showed that the proposed parameters significantly reduce word error rates and exhibit greater gender independence than the baseline MFCCs.

Transportation is an important part of this era of globalization. But at the same time transportation, especially in the field of logistics, often harms the environment. This research will then look at the impact of sustainable transportation and the implementation of green logistics on the environment. This research will be carried out using a descriptive qualitative approach. The data used in this study comes from various relevant previous research results or studies. The results of this study then found that the negative impact of conventional transportation led to the importance of changes in transportation management. Through the adoption of innovative technology, smart route management, and environmentally friendly vehicles, a company will be able to reduce operational costs, increase efficiency, and significantly reduce the negative impact it has on the environment. Sustainable transportation and green logistics are strategic opportunities for future businesses.

NV-5138 (or SPN-820) is a novel small molecule activator of the mechanistic target of rapamycin complex 1 (mTORC1) currently under development for use in treatment- resistant depression. This phase I study evaluated the safety, tolerability, and pharmacodynamics (as measured by quantitative electroencephalography, qEEG) of two sequential oral doses of NV-5138 in healthy adult males. Twenty-five participants were randomly assigned to double-blind treatment with a single dose of placebo or 2400 mg NV-5138 on Day 1, and a second dose of the same treatment on Day 3. The two doses of NV-5138 were safe and well tolerated, with no deaths, serious adverse events, or discontinuations due to adverse events. Spectral band amplitudes, derived frequency measures, and magnitude squared coherences were computed from qEEG recordings during resting state eyes-open and eyes-closed conditions at multiple timepoints. In the NV-5138 group only, significant changes in qEEG measures occurred at 1 hour post-dose on both days (near NV-5138 T max ), including decreases in low-frequency band amplitudes (theta) and increases in high-frequency EEG band amplitudes (high beta and gamma). These effects were mirrored by a decrease in the theta/beta ratio, a measure negatively associated with arousal and cognitive processing capability. Significantly increased high beta and gamma band coherences were also detected at several specific electrode pairs in both eyes-open and eye-closed conditions. NV-5138 actively modulated functional brain parameters consistent with positive effects on mood, cognition, and arousal. These results indicate that qEEG measures may be useful biomarkers of NV-5138 target engagement and related changes in neural activity.

Abstrak—Dari seluruh hukum yang berlaku saat ini, hukum kewarisan mempunyai peran yang begitu penting bahkan juga menentukan serta mencerminkan sistem kekeluargaan yang berlaku didalam masyarakat. Akhir-akhir ini sangat banyak sengketa yang timbul akibat dari kasus permohonan ahli waris yang meninggal terlebih dahulu dari seorang pewaris tersebut. Kasus tersebut memiliki jalan keluar dengan dibentuknya sebuah konsep tentang ahliwaris pengganti. Permasalahan hukum tentang penggantian ahliwaris merupakan sebuah konsep yang diperbaharui dalam KHI. Konsep ahli waris pengganti bertujuan untuk memperoleh rasa keadilan bagi ahli waris. Adapun rumusan masalah yang diangkat adalah (1) Bagaimana kedudukan cucu sebagai ahliwaris pengganti didalam sistem kewarisan Islam menurut KHI? dan (2) Bagaimanakah perttimbangan majelis hakim terhadap kedudukan cucu sebagai ahliwaris pengganti didalam Permohonan Penetapan PA Denpasar Nomor: 0013/Pdt.p/2015/Pa.Dps.? Dalam penelitian ini menggunakan penelitian hukum normatif yaitu dalam pengkajiannya mengolah bahan-bahan kepustakaan serta berkas putusan yang berkaitan. Kesimpulan dari penelitian ini dapat dikatakan cucu yang berkedudukan sebagai ahli waris pengganti didalam sistem kewarisan Islam menurut KHI PA Denpasar mengeluarkan Penetapan Nomor: 0013/Pdt.p/2015/Pa.Dps bahwa cucu tersebut bisa menggantikan posisi kedua orang tuanya yang dapat disebut ahli waris, karena sesuai Psl 185 ayat 1 KHI, seseorang dikatakan bisa mendapatkan warisan karena memperoleh kedudukan yaitu seseorang yang telah diganti harus sudah dalam keadaan meninggal dunia lebih awal dari pada si pewaris .

The detection and quantification of the concentration of exogenous chromophores in-vivo by their fluorescence is complicated by many physical and geometrical parameters. Measurement of such signals is advantageous in determining the pharmacokinetics of photosensitizers such as those used in photodynamic therapy (PDT) or to assist in the diagnosis of tissue histological state. To overcome these difficulties a ratio based fiber optic contact fluorometer has been developed. This fluorescence detection system (FDS) uses the ratio of the fluorescence emission peak of the exogenous chromophore to that of endogenous chromophores, i.e. autofluorescence, to correct for a variety of parameters affecting the magnitude of the measured signals. By doing so it also minimizes the range of baseline measurements prior to exogenous drug injection, for various tissue types. Design of the FDS and results of its testing in animals and patients using the second generation photosensitizer Tin ethyletiopurpurin (SnET2) are presented. These results support the feasibility and usefulness of the Ratio FDS system.

A series of experiments was undertaken to determine the uptake of the photosensitizer tin ethyl etiopurpurin in the canine prostate. At increasing time intervals after intravenous injection, tissue photosensitizer levels were determined for the prostate, urinary bladder and other selected sites. Tissue effects resulting from either transurethral or transperineal delivery of light to the prostate after tin ethyl etiopurpurin-photosensitization were then assessed by light microscopy. Both resulted in hemorrhagic necrosis of the target prostatic tissue. Photodynamic therapy of the prostate using tin ethyl etiopurpurin as photosensitizer for the treatment of both benign prostatic enlargement and adenocarcinoma is worth of further investigation.

Cylindrical light diffusion is a key element in a variety of medical applications which require the controlled administration of light to a treatment site within the body. Applications such as photodynamic therapy (PDT), laser induced hyperthermia (LHT), and photoatherolytic (PAL) therapy may all require that light be diffused in this manner. Cylindrical diffusers are typically used in tubular cavities, such as the bronchus, trachea, or the esophagus, and in interstitial applications where uniform illumination over a specified length is required to maximize the therapeutic response. A third generation of cylindrical diffuser with improved performance has been developed to more effectively meet these needs. This paper will discuss the evolution of cylinder diffusers and will describe the characteristics and performance of this new generation device.