Parkland College

Introduction: Perioperative hypotension is common in kidney transplant recipients and linked with poor allograft outcomes. We use synthetic angiotensin II (AT2S) as the first-line vasopressor for these patients. Lack of evidence exist evaluating the impact of obesity on AT2S requirements and allograft function in this population. We hypothesize that kidney transplant patients with obesity require a longer AT2S duration, higher AT2S doses, and have increased rates of delayed graft function (DGF). Methods: This retrospective, single-center, cohort study compared AT2S use and allograft function in kidney transplanted patients with and without obesity. Included patients were adults who underwent an isolated kidney transplant and required vasopressors perioperatively with AT2S. Data was collected from the date of transplant until 28 days post-operative. We identified 305 eligible patients from 1/2021-9/2024. Co-primary endpoints included differences in vasopressor duration, dose, and allograft function. Statistical analysis of study endpoints was assessed using descriptive and inferential statistics. Results: 305 patients (N=179 obese, N=126 non-obese) were included with balanced baseline characteristics, except significant differences in race, diabetes, hemodialysis duration, and transplant duration (P< 0.05). AT2S duration (hours) [17 (3-52.3) vs. 6.5 (1.75-29.4) hours (P< 0.001)], total dose received (mcg) [2977.8 (1012.2-7327) vs. 1025.8 (282.6-1866.1) mcg (P< 0.001), and rates of delayed graft function 36.3% vs. 20.6% (P=0.003) were higher in patients with obesity. Linear regression showed pre-operative hemodialysis duration and post-operative propofol to be associated with both AT2S duration and dose (P< 0.05). Propofol dose, cold-ischemic time, vasopressor duration, and donor terminal Scr were associated with DGF (P< 0.05). Conclusions: Obese kidney transplanted recipients required higher doses of AT2S for longer durations and had a higher incidence of DGF. This is consistent with prior evidence linking obesity to increased DGF risk. The higher doses may reflect longer transplant surgeries, more profound inflammatory response during surgery, or increased propofol requirements for obese patients. Further exploration is needed to investigate these observations.

Abstract The study will focus on the quantitative assessment of nine stories, considered important contributions in the supernatural and in the early and modern science-fiction prose. Besides the two treatments of the topic of imaginary Flatland – penned by E. A. Abbott and C. H. Hinton –, the corpus includes writings by H. G. Wells, A. Blackwood, M. Leinster, G. Waldeyer, R. A. Heinlein, L. Padgett, and A. C. Clarke. Texts are researched on the bases of four analyses (moving-average type-token ratio, average tokens length, Busemann’s coefficient, and collocation associativity), with the results tested for statistical significance; next, the textual comparisons will provide a springboard for sketches of literary criticism interpretations. The analyzed corpus has revealed the distinctive and colorful take writers have in their stories. By the nature of their subject, the texts are expected to share higher dimensions and time warps, a thread implying a meeting point in terms of vocabulary richness, plot development, and possibly of narrative structure. Yet, in most cases, the findings suggest basic and nuanced differences, hinting at clear stylistic physiognomies in the authorship. The outcome affects not only the assessment of the weight individual samples have, but also the interface between a common (sub)genre and personal style.

It was believed that children with better motor function and skills will be likely more physically active. Yet, contribution of fitness, especially muscular strength, to children’s motor function and skill has not been well understood. PURPOSE: To examine the relationship between core and upper-body strength and gross motor function in children using a US national sample. METHODS: Three data sets in the 2012 National Youth Fitness Survey (NNYFS) were merged: Test of Gross Motor Development – Second Edition (TGMD-2), modified pull-up, and plank. TGMD-2 total score (TGMD-2 TS) was calculated by adding “Local motor subtest raw score” and “Object control subtest raw score” together. Descriptive statistics and correlations of TGMD-2 TS, “# of correctly completed modified pull-ups (M-Pull-up)”, and “# of seconds planks position is held (Planks)” were computed using the 2012 NNYFS data. RESULT: A total of 6375389 of boys and 6134317 of girls who aged between 3 and 5 yr. old participated in 2012 NNYFS, and their performances (M±SD) in gross motor function and fitness, as well as their correlations (r), are summarized below: Table CONCLUSION: As children become older, core and upper-body strength seems playing a positive impact on children’s gross motor function in both boys and girls.