Pavia nel Cuore

Specific Learning Disorder (SLD) is a neurodevelopmental condition affecting 5-15% of children worldwide, typically involving difficulties in reading, writing, and/or mathematics. Dyslexia is the most common subtype. These disorders impact both children and their parents, highlighting the need for emotional and educational support to help families manage SLD-related challenges. Although various parenting programmes exist, little is known about which features make some interventions more effective than others. This systematic review assessed the effectiveness of psychotherapeutic and psychoeducational parenting interventions. A comprehensive search was conducted across multiple databases for studies published between 1950 and 2024, following PRISMA guidelines. From 1,519 records, 10 studies met the predefined inclusion criteria. The included studies showed that parental support interventions improved parents' emotional well-being and coping strategies. These improvements were linked to better academic, behavioural, and social outcomes in children. Interventions differed in format and delivery, but all focused on strengthening parental skills and knowledge. Parenting interventions that combine emotional and educational support appear beneficial for both parents and children. They foster environments that support children's development. Further research is needed to identify the most effective components and delivery methods across diverse populations.

Article Silberstein, Dagmar: Modalpartikeln als Lerngegenstand. Partikelprofile für die Vermittlung von aber, ja, doch, mal, denn, eigentlich und etwa im DaF-Unterricht. Berlin: Erich Schmidt, 2024. – ISBN 978-3-503-23754-8. 485 Seiten, € 87,43. was published on April 1, 2025 in the journal Informationen Deutsch als Fremdsprache (volume 52, issue 2-3).

Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting 10-25 years before the onset of clinical symptoms. As multiple functionally interconnected molecular/cellular pathways appear disrupted in AD, the exploitation of high-throughput unbiased omics sciences is critical to elucidating the precise pathogenesis of AD. Among different omics, metabolomics is a fast-growing discipline allowing for the simultaneous detection and quantification of hundreds/thousands of perturbed metabolites in tissues or biofluids, reproducing the fluctuations of multiple networks affected by a disease. Here, we seek to critically depict the main metabolomics methodologies with the aim of identifying new potential AD biomarkers and further elucidating AD pathophysiological mechanisms. From a systems biology perspective, as metabolic alterations can occur before the development of clinical signs, metabolomics - coupled with existing accessible biomarkers used for AD screening and diagnosis - can support early disease diagnosis and help develop individualized treatment plans. Presently, the majority of metabolomic analyses emphasized that lipid metabolism is the most consistently altered pathway in AD pathogenesis. The possibility that metabolomics may reveal crucial steps in AD pathogenesis is undermined by the difficulty in discriminating between the causal or epiphenomenal or compensatory nature of metabolic findings.

During the last decade, physical activity (PA) (or "exercise") has been identified as one of the main modifiable factors that influence the development of Alzheimer's disease (AD) pathophysiology. We performed an umbrella review to summarize the evidence on the association between PA/exercise and the risk of developing AD risk, and the effect of exercise interventions on the progression of AD. A systematic search was performed in PubMed, SportDiscus, Cochrane Library and Web of Science (March 2022) to identify meta-analyses assessing the association between PA and the incidence of AD, and assessing the effect of exercise interventions on patients with AD. Twenty-one studies were included. The results with strongest evidence revealed the positive effects of PA on AD risk. Specifically, meeting the WHO recommendations for PA was associated with a lower risk of AD. They also revealed positive effects of exercise on cognitive function, physical performance, and functional independence. There is strong evidence of a protective effect of regular PA against AD risk; however, the dose-response association remains unclear. Physical exercise seems to improve several dimensions in patients with AD, although research is warranted to elucidate the exercise characteristics that promote the greatest benefits.

Cet article se propose d’étudier quelques chapitres du Centheologicon d’Heymeric de Campo consacrés aux doctrines de Nicolas de Cues. La relation d’amitié entre les deux philosophes rend compte de leur mutuelle influence doctrinale et de la convergence de leurs perspectives philosophiques. L’analyse de cinq chapitres du Centheologicon , dont la source est Nicolas de Cues, permettra d’évaluer la correspondance théorique réelle entre ces chapitres et les ouvrages cusaniens. L’étude met en avant la consonance doctrinale des deux auteurs qui partagent la même conception unitaire et universelle du savoir humain.

Diabetic retinopathy (DR) is a common complication of diabetes mellitus and is the major cause of vision loss in the working-age population. Although DR is traditionally considered a microvascular disease, an increasing body of evidence suggests that neurodegeneration is an early event that occurs even before the manifestation of vasculopathy. Accordingly, attention should be devoted to the complex neurodegenerative process occurring in the diabetic retina, also considering possible functional alterations in non-neuronal cells, such as glial cells. In this work, we investigate functional changes in Müller cells, the most abundant glial population present within the retina, under experimental conditions that mimic those observed in DR patients. More specifically, we investigated on the Müller cell line rMC-1 the effect of high glucose, alone or associated with activation processes and oxidative stress. By fluorescence microscopy and cellular assays approaches, we studied the alteration of functional properties, such as reactive oxygen species production, antioxidant response, calcium homeostasis, and mitochondrial membrane potential. Our results demonstrate that hyperglycaemic-like condition per se is well-tolerated by rMC-1 cells but makes them more susceptible to a pro-inflammatory environment, exacerbating the effects of this stressful condition. More specifically, rMC-1 cells exposed to high glucose decrease their ability to counteract oxidative stress, with consequent toxic effects. In conclusion, our study offers new insights into Müller cell pathophysiology in DR and proposes a novel in vitro model which may prove useful to further investigate potential antioxidant and anti-inflammatory molecules for the prevention and/or treatment of DR.

The theme of urban regeneration is currently one of the main actions of transformation policies. It presents an opportunity for cities’ design, in particular historical centers, through joint actions aimed at creating synergies and connections between social, political, economic, and environmental aspects. It also becomes an opportunity to enhance the huge and complex Cultural Heritage, full of architectural values, memory, and history. At the same time, it appears increasingly inadequate and obsolete compared to the new needs of a changing society, of regulatory aspects, and of a general compatible approach to intervention to the more general policies of sustainable development, as required by the 2030 Agenda for Sustainable Development. A total of two case studies of the reuse and enhancement of hospital buildings of the University of Pavia are presented, which has a large building heritage spread throughout the city. In recent years, owing to the opportunities offered by funding, it has started transformation policies on some abandoned buildings through projects based on an interdisciplinary approach and a participatory design strategy. The article testifies to a potential method of intervention that can be exported to other contexts, after a previous test of the compatibility on the existing and on the urban context.

Common responses to induced seismicity are based on control of the anthropogenic activity causing the earthquakes, such as fluid injection or withdrawal, in order to limit either the magnitudes of the events or the level of ground motion to within established thresholds. An alternative risk‐mitigation option is seismic retrofitting of the more vulnerable buildings potentially exposed to the ground shaking to reduce the risk to acceptable levels. Optimal mitigation strategies may combine both production control and structural strengthening, for which a probabilistic risk model is required that can estimate the change in hazard caused by production or injection variations and the changes in fragility resulting from structural interventions. Such a risk model has been developed for the Groningen gas field in the Netherlands. The framework for this risk model to inform decision making regarding mitigation strategies can be adapted to other cases of anthropogenically induced seismicity.