Perrigo (United States)

Lithium-sulfur (Li-S) batteries hold immense promise as next-generation energy storage due to their high theoretical energy density (2600Whkg⁻¹), low cost, and non-toxic nature. However, practical implementation faces challenges, primarily from Li polysulfide (LiPS) shuttling within the cathode and Li dendrite growth at the anode. Optimized electrodes/electrolytes design effectively confines LiPS to the cathode, boosting cycling performance in coin cells to up to hundreds of cycles. Scaling up to larger pouch cells presents new obstacles, requiring further research for long-term stability. A 1.45Ah pouch cell, with optimized sulfur loading and electrolyte/sulfur ratio is developed, which delivers an energy density of 151Whkg-1 with 70% capacity retention up to 100 cycles. Targeting higher energy density (180Whkg-1), the developed 1Ah pouch cell exhibits 68% capacity retention after 50 cycles. Morphological analysis reveals that pouch cell failure is primarily from Li metal powdering and resulting polarization, rather than LiPS shuttling. This occurs for continuous Li ion stripping/plating during cycling, leading to dendrite growth and formation of non-reactive Li powder, especially under high currents. These issues increase ion diffusion resistance and reduce coulombic efficiency over time. Therefore, the study highlights the importance of a protected Li metal anode for achieving high-energy-dense batteries.

materno, Giuseppe Podest, haban llegado aqu desde la Liguria y se dedicaron a negocios relacionados con la comida. La familia paterna (mi abuelo, su hermano, mi padre) fue propietaria del Restaurante Perosio que funcionaba en Suipacha y Diagonal

Oligosaccharides in human milk support health via intestinal microbiome. We studied effects of addition of 2-fucosyllactose (2′FL) to the infant formula on infant growth, occurrence of adverse events (AE), and infant microbiome, including expression of microbial genes that metabolize 2′FL. Our hypothesis was that while 2′FL would not affect growth, it would cause changes in microbiome metabolism. In a double-blinded randomized controlled study fashion, the infant formula ± 2′FL or human milk was fed to healthy term infants for 16 weeks. Fecal samples obtained at baseline and week 16 were analyzed for microbial populations, metagenomic species concept (MGS), and genetics of gut metabolic modules (GMMs). There were no effects of addition of 2′FL on growth or AEs. There were no significant differences by feeding group in MGS richness or Shannon diversity at baseline, but formula groups each had significantly greater richness (p < 0.05) and diversity (p < 0.05) after 16 weeks of feeding than the breastfed group. While two glycosyl hydrolase (GH) families (GH42 and GH112) were significantly increased, two other GH families (GH20 and GH2) were significantly decreased in the test formula group compared to the control formula group; although modest, addition of 2′FL resulted in changes in microbiome in the direction of breastfed infants, consistent with internal metabolism of HMOs by Bifidobacterium.

&#x0D; &#x0D; &#x0D; &#x0D; Penelitian ini mendeskripsikan tentang Evaluasi Program pemberian makanan tambahan untuk penanganan gizi buruk balita di Kabupaten Aceh Utara. Tujuan penelitian ini adalah untuk menjelaskan Evaluasi Program pemberian makanan tambahan dalam penanganan kasus balita gizi buruk, serta faktor yang menjadi hambatan dalam upaya penanganan gizi buruk balita di kabupaten Aceh Utara, penelitian ini dilakukan di Kabupaten Aceh utara dengan mengambil sampel di Puskesmas Babah Buloh yang terletak di Ujung barat dan Puskesmas Seunuddon yang terletak di ujung Timur Kabupaten Aceh Utara, penelitian ini penting untuk dilakukan karena Kabupaten Aceh Utara merupakan daerah tertinggi dalam kasus gizi buruk. Dalam subjek penelitian ini, yang menjadi informan adalah Dinas Kesehatan Kabupaten Aceh Utara, Puskesmas Babah Buloh dan Puskesmas Seunuddon Kabupaten Aceh Utara serta Stakeholder terkait lainya. Metode penelitian yang digunakan yaitu metode kualitatif. Teknik pengumpulan data yang digunakan yaitu melalui wawancara langsung dan penelitian dokumentasi atau kepustakaan. Teori yang digunakan dalam penelitian ini adalah Evaluasi Program. Hasil penelitian menunjukkan bahwa Evaluasi program pemberian makanan tambahan untuk penanganan gizi buruk sudah dilakuakan, dengan upaya pencegahan dan pemebrian makanan tambahan, namun pemberian makanan tambahan untuk balita belum semua daerah tersentuh karena adanya keterbatasan, kurangnya tenaga ahli di bidang gizi, bahkan hamper diseluruh puskesmas di Kabupaten Aceh Utara tidak memiliki ahli Gizi serta masih lemahnya komunikasi antara puskesmas dengan Dinas kesehatan Kabupaten Aceh Utara, sehingga kasus gizi buruk balita di Kabupaten Aceh Utara terus bertambah.&#x0D; &#x0D; Kata Kunci: Evaluasi Program, Gizi buruk Balita, Dinas Kesehatan Kabupaten Aceh Utara.&#x0D; &#x0D; &#x0D; &#x0D;

This study explored the experiences and perspectives of Latinx mothers of children younger than 3 years who had participated in a developmental screening initiative provided by 2 Federally Qualified Health Centers in an urban setting, had positive developmental screenings, and were referred to early intervention (EI) services. A 2-phase mixed-methods explanatory design was implemented in English and Spanish. In Phase 1, a telephone survey was conducted with 62 parents. In Phase 2, qualitative semistructured interviews (regarding parental experiences with their child's developmental screening, the process of linking to services, the EI evaluation, and subsequent services received) were conducted with a subset of 13 Phase 1 mothers. Results from the phone survey showed that 91% of children were found eligible for EI and 92% were receiving EI services. More than 90% of mothers reported positive experiences with their children's developmental screening, learning about their child's development, and accessing services. However, results from the semistructured interviews revealed that mothers had mixed experiences with the developmental screening process and linkage to EI services. Findings from this study provide insights into the perceived value of EI services by Latinx families and the need for improved system supports to access and navigate EI services.

IntroductionTraditional statistical techniques for extrapolating short-term survival data for anticancer therapies assume the same mortality rate for noncured and “cured” patients, which is appropriate for projecting survival of non-curative therapies but may lead to an underestimation of the treatment effectiveness for potentially curative therapies. Our objective was to ascertain research trends in survival extrapolation techniques used to project the survival benefits of chimeric antigen receptor T cell (CAR-T) therapies.MethodsA global systematic literature search produced a review of survival analyses of CAR-T therapies, published between January 1, 2015 and December 14, 2020, based on publications sourced from MEDLINE, scientific conferences, and health technology assessment agencies. Trends in survival extrapolation techniques used, and the rationale for selecting advanced techniques, are discussed.ResultsTwenty publications were included, the majority of which (65%, N = 13) accounted for curative intent of CAR-T therapies through the use of advanced extrapolation techniques, i.e., mixture cure models [MCMs] (N = 10) or spline-based models (N = 3). The authors’ rationale for using the MCM approach included (a) better statistical fits to the observed Kaplan–Meier curves (KMs) and (b) visual inspection of the KMs indicated that a proportion of patients experienced long-term remission and survival which is not inherently captured in standard parametric distributions.DiscussionOur findings suggest that an advanced extrapolation technique should be considered in base case survival analyses of CAR-T therapies when extrapolating short-term survival data to long-term horizons extending beyond the clinical trial duration.ConclusionAdvanced extrapolation techniques allow researchers to account for the proportion of patients with an observed plateau in survival from clinical trial data; by only using standard-partitioned modeling, researchers may risk underestimating the survival benefits for the subset of patients with long-term remission. Sensitivity analysis with an alternative advanced extrapolation technique should be implemented and re-assessment using clinical trial extension data and/or real-world data should be conducted as longer-term data become available.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12325-021-01841-4.