Philips (Belgium)

In this work, we studied the potential of the visible, near-infrared, and shortwave infrared wavelength regions for monitoring oil spill incidents using optical reflectance. First, a simple physical model was designed for accurate oil thickness and volume estimation using optical reflectance. The developed method was made invariant to changes in acquisition and illumination conditions. In the next step, an algorithm based on an artificial neural network was designed to detect spilled oil. The training samples that are required to optimize the parameters of the network were generated by utilizing the proposed physical model. To validate the method, experiments were conducted in laboratory and outdoor scenarios for detection and thickness/volume estimation on four different oil types. In particular, we developed hyperspectral datasets of oil samples with varying thickness between 500 µm and 5000 µm acquired using two different sensors, an Agrispec spectrometer and an Imec snapscan shortwave infrared hyperspectral camera, in strictly controlled experimental settings. To demonstrate the potential of the proposed method in outdoor environments using solely the visible wavelength region, we monitored the evolution of artificially spilled oil in an outdoor scene with an RGB camera mounted on a drone.

To evaluate the relationships between pulmonary transit time (PTT), cardiac function, and pulmonary haemodynamics in patients with heart failure with reduced ejection fraction (HFrEF) and to explore how PTT performs in detecting pulmonary hypertension (PH). In this prospective study, 57 patients with advanced HFrEF [49 men, 51 years ± 8, mean left ventricular (LV) ejection fraction 26% ± 8] underwent echocardiography, right heart catheterization, and cardiac computed tomography (CT). PTT was measured as the time interval between peaks of attenuation in right ventricle (RV) and LV and was compared between patients with or without PH and 15 controls. PTT was significantly longer in HFrEF patients with PH (21 s) than in those without PH (11 s) and controls (8 s) (P < 0.001) but not between patients without PH and controls (P = 0.109). PTT was positively correlated with pulmonary artery wedge pressure (PAWP) (r = 0.74), mean pulmonary artery pressure (r = 0.68), N-terminal pro-B-type natriuretic peptide (r = 0.60), mitral (r = 0.54), and tricuspid (r = 0.37) regurgitation grades, as well as with LV, RV, and left atrial volumes (r from 0.39 to 0.64) (P < 0.01). PTT was negatively correlated with cardiac index (r = -0.63) as well as with LV (r = -0.66) and RV (r = -0.74) ejection fractions. PAWP, cardiac index, mitral regurgitation grade, and RV end-diastolic volume were all independent predictors of PTT. PTT value ≥14 s best-detected PH with 91% sensitivity and 88% specificity (area under the receiver operating characteristic curve: 0.95). In patients with HFrEF, PTT correlates with cardiac function and pulmonary haemodynamics, is determined by four independent parameters, and performs well in detecting PH.

Abstract The legal status and binding nature of various international governance and guidance instruments to foster and support quality strategies in European countries differs substantially. This presentation introduces and discusses the four main elements of an integrated international governance framework for quality in health care: i) raising political awareness of the relevance of health care quality and creating a common vision on how to improve it; ii) implementing this vision into actual policy frameworks by sharing experience and practice between countries; iii) developing and providing standards and models (voluntary or mandatory) that can be transposed into national policy; iv) measuring, assessing and comparing quality by developing better information, better indicators and methodologies as well as dissemination strategies. The presentation will also focus on how quality in health care is addressed through EU policy, first through EU provisions and policies that are meant to ensure free movement of citizens and goods and establish an internal market, and by means of more horizontal and generic EU policies on quality and safety that stem from the mandate to support, coordinate or supplement national policies. It will further highlight how EU integration and policy touch upon quality in health care and how the approach has evolved over time.

Rapid technological advancements have enabled cardiac computed tomography angiography (cardiac CTA) to become the noninvasive modality of choice for the rule-out of coronary artery disease (CAD). Advances have been driven by progress in CT hardware technology, image reconstruction, and post-processing software. Diagnostic performance of cardiac CTA has been improved by the faster gantry rotational times and the corresponding improvement in temporal resolution. Another crucial contribution has been the development of large coverage detectors with more rows added, enabling to go from spiral to prospective axial acquisitions and reduce the dose exposure by as much as 80%. The development of iterative and other advanced reconstruction methods have facilitated this radiation dose reduction further in combination with improvements in low contrast and spatial resolution, making it also possible for functional information, such as myocardial perfusion and flow information to be extracted as well from cardiac CTA. Novel approaches have been developed to address functional motion analysis and motion artifact reduction for improved anatomic analysis. Cardiac dual-energy CT is among the latest developments which might enable further improvements in the diagnostic performance and robustness of this application, and give CT the potential to become the prime imaging modality in the field of cardiovascular medicine.

To prospectively assess liver ADC (apparent diffusion coefficient) repeatability from cardiac-triggered diffusion-weighted images obtained with an individually predetermined optimal cardiac time window minimizing cardiac-related effects and to evaluate a signal filtering method aimed at artifact elimination. After Institutional Review Board approval and written informed consent, eight healthy volunteers underwent four repetitions of respiratory-triggered diffusion-weighted sequences (3T, b: 0,150,500 s/mm(2) ) without (RTnoCT, 51 sec) and with individually optimized cardiac triggering (RTCT, 306 sec). The optimal cardiac delay was individually predetermined using a 5-second breath-hold sequence. Monoexponential liver ADC and left-to-right-liver ADC ratio were computed from region of interest (ROI) signal measurements (two independent readers). A filtering method, excluding signal intensities lower than the mean intensity at fixed b-value, provided ADC recalculation. Limits-of-agreement (LOAs) from 95% confidence intervals for differences across the four repetitions provided the variability range. For Reader 1 (Reader 2), left-to-right-liver ADC ratios were significantly higher in RTnoCT 1.51 (1.52) than in RTCT 1.12 (1.15), P = 0.012 (P = 0.017). Respectively for RTnoCT and RTCT: left liver LOAs were ±835 (±775), ± 315 (±369) 10(-6) mm(2) /s; right liver LOAs were ±392 (±445), ± 172 (±140) 10(-6) mm(2) /s: LOAs were larger in the left than in the right lobe (both P < 0.001). After filtering, left liver ADC LOAs narrowed to ±650 (±367) 10(-6) mm(2) /s, P = 0.17 (P < 0.001); ± 152 (±208) 10(-6) mm(2) /s (both P < 0.002) and left-to-right-liver ADC ratio decreased to 1.28 (1.20), P = 0.017 (P = 0.012); 1.09 (1.08), P = 0.106 (P = 0.105). Compared to noncardiac-triggered acquisitions, individually optimized cardiac-triggered acquisitions improved ADC repeatability in both liver lobes and reduced ADC differences between left and right liver. Left liver ADC repeatability was further improved after signal filtering.

The paper examines the breakdown process at 100 kHz in a changing temperature-dependent mixture of Ar and Hg and the associated transitions between breakdown regimes. Each measurement series started at 1400 K, 10 bar of Hg, and 0.05% admixture of Ar and finished by natural cooling at room temperature, 150 mbar of Ar, and 0.01% admixture of Hg. The E/N at breakdown as a function of temperature and gas composition was found to have a particular shape with a peak at 600 K, when Hg makes up for 66% of the gaseous mixture and Ar 34%. This peak was found to be an effect of the mixture itself, not the temperature effects or the possible presence of electronegative species. The analysis has shown that at this frequency both streamer and diffuse breakdown can take place, depending on the temperature and gas composition. Streamer discharges during breakdown are present at high temperatures and high Hg pressure, while at room temperature in 150 mbar of Ar the breakdown has a diffuse nature. In between those two cases, the radius of the discharges during breakdown was found to change in a monotonic manner, covering one order of magnitude from the size typical for streamer discharges to a diffuse discharge comparable to the size of the reactor.

Because of its paramagnetic properties, oxygen may act as an endogenous magnetic resonance imaging contrast agent by changing proton relaxation rates. Changes in tissue oxygen concentrations have been shown to produce changes in relaxation rate R1 of water. The aim of the study was to improve the sensitivity of oxygen enhanced R1 imaging by exploiting the higher solubility of oxygen in lipids (as compared with water) to sensitively monitor changes in tissue oxygen levels by selectively measuring the R1 of lipids. The method, with the acronym "MOBILE" (mapping of oxygen by imaging lipids relaxation enhancement), was applied in different mouse models of hypoxic processes on a 11.7 T magnetic resonance imaging system. MOBILE was compared with R*2, R1 of water, and with pO2 measurements (using electron paramagnetic resonance oximetry). MOBILE was also applied in the brain of healthy human volunteers exposed to an oxygen breathing challenge on a 3 T magnetic resonance imaging system. MOBILE was shown to be able to monitor changes in oxygenation in tumor, peripheral, liver, and brain tissues. The clinical translation was demonstrated in human volunteers. MOBILE arises as a promising noninvasive and sensitive tool for diagnosis and therapeutic guidance in disorders involving hypoxia.