Pieris Pharmaceuticals (United States)

Van Berkhey, Reader in Natural History at the University of Leiden in the Dutch Republic, was financially ruined around 1784–85, an event which led to the sale of his books and manuscripts and his natural history cabinet, which were widely dispersed. He had assembled a famous iconographical collection of over 6,000 drawings and prints of naturalia (many of which he had drawn himself), arranged according to the Linnaean system. These were sold by auction in 1785 as an entity, to an unknown bidder, for the cabinet of King Carlos III of Spain and then preserved in Madrid. This fact has become internationally known only recently.

This study explores the perceived positive and negative consequences, as well as the spontaneous self-concept of 60 individuals who have achieved successful weight loss. Using a descriptive-transversal, exploratory design and Directed Qualitative Content Analysis, semi-structured interviews were analyzed. A quantitative exploration of the associations between the emergent categories was conducted using multiple correspondence analysis, which revealed a four-factor model: (1) all gains (health, psychological and social) but the body image, (2) role-model and bodily efficacious with fallouts (psychological and family), (3) body satisfaction and sexual disinhibition, and (4) supported while bodily unsatisfied. The findings highlight the dual nature of successful weight loss, showing both positive and negative consequences that should be considered in intervention planning. Additionally, the qualitative analysis of self-concept contributes to the growing literature in this field. A predominantly positive spontaneous self-concept was observed, suggesting that both dimensions may enhance success, making their understanding crucial for effective interventions.

<bold>Background:</bold> Elarekibep (AZD1402/PRS-060) is an inhaled Anticalin® protein engineered to inhibit IL-4 receptor alpha signaling, a clinically validated asthma target. <bold>Methods:</bold> A two-part Phase 2a randomized, double-blind, placebo-controlled, dose ranging study in adults (<ext-link>NCT04643158</ext-link>). Part 1 evaluated safety and PK following 28 days twice daily dosing with dry powder formulated elarekibep (1, 3, 10mg) or placebo in controlled patients (ACQ-6 ≤ 1.0) on a stable medium ICS-LABA dose. Part 2 evaluated efficacy of elarekibep (1, 3mg) versus placebo following twice daily dosing for 28 days in a T2-high, uncontrolled moderate-severe asthma population. <bold>Results:</bold> 72 patients randomized (Part 1: n=50; Part 2: n=22). No clinical safety concerns were reported; the study was stopped early due to new non-clinical findings. Treatment-emergent adverse events were reported for 56.0% (elarekibep, 58.8%; placebo, 50.0%) of patients in Part 1 and 63.6% (elarekibep, 61.5 %; placebo, 66.7%) in Part 2. One SAE, in the 3mg group, was reported during follow up. After inhalation, elarekibep was steadily absorbed (Tmax 3-4 hours) with an elimination half-life ranging between 8-20 hours. Treatment emergent ADAs were detected in 83% (n= 38/46) of elarekibep exposed individuals with no impact on PK characteristics. At Week 4, the LS mean increase (95% CI) in prebronchodilator FEV1 of the 3mg elarekibep group was 196ml (14.3; 378) compared to placebo. <bold>Conclusions:</bold> Elarekibep was clinically well-tolerated with no identified short-term safety concerns. Due to early study termination, firm conclusions about efficacy could not be drawn. Clinical development has been discontinued due to pre-clinical findings.

Raymond Aron a été un des grands analystes des tragédies, évolutions et grands débats idéologiques du siècle dernier. Lecteur et admirateur de Thucydide, il a mis à contribution l’héritage de l’historien de la Guerre du Péloponnèse pour éclairer sa réflexion sur le xxe siècle. Cette contribution souhaite en souligner quelques aspects.

Située dans la garenne du château médiéval d’Ivry-la-Bataille, la « Grotte du sabotier » fait l’objet d’une fouille programmée visant à en préciser les différentes fonctions et occupations. La campagne 2010 a révélé une structure particulière, une zone d’habitat troglodytique contigüe à un espace présentant des traces de structures destinées à l’hébergement d’animaux ainsi qu’un intéressant ensemble de graffiti (croix et dates gravées).