Pierre Fabre (Germany)

Tractarem ací de l'edifici de la basílica-sinagoga d'Ilici, descobert el 1905 i present a moltes de les publicacions dedicades al paleocristianisme hispànic des de llavors ençà. N'analitzarem els processos del descobriment i les excavacions, les característiques constructives i les principals troballes efectuades. Però també parlarem de les inscripcions gregues del mosaic policrom, mostrarem novetats pel que fa a la necròpolis ad sanctos immediata a la basílica, i algunes consideracions envers l'antic debat pel caràcter jueu o cristià de l'edifici. Finalment ens centrarem en criticar l'última -i massa reculada- datació fundacional, així com en defensar-ne una altra possibilitat, ja suggerida d'antic.

Adam Smith's idea of poverty has been misinterpreted in some literature for associating pauperism with his vision of liberal laissez-faire. There are few works that discuss Smith's idea about the causes of poverty. This article exposes some aspects of the economist's social philosophy, based on a theoretical review of his main works and works by researchers of Smithian thought. The work concludes that Smith offers ethical arguments in favor of the free market to improve the living conditions of the poor, recognizing the economic and motivational aspects of the complex phenomenon of poverty.

Heart failure (HF) contributes to circa 200,000 annual hospitalizations in France. With the increasing age of HF patients, elucidating the specific causes of inpatient mortality became a public health problematic. We introduce a novel methodological framework designed to identify prevalent health trajectories and investigate their impact on death. The initial step involves applying sequential pattern mining to characterize patients' trajectories, followed by an unsupervised clustering algorithm based on a new metric for measuring the distance between hospitalization diagnoses. Finally, a survival analysis is conducted to assess survival outcomes. The application of this framework to HF patients from a representative sample of the French population demonstrates its methodological significance in enhancing the analysis of healthcare trajectories.

À partir de la nouvelle de Barbey d’Aurevilly, « Le plus bel amour de Don Juan », extraite du recueil Les diaboliques (1874), l’auteur fait l’hypothèse que la théorie sexuelle hallucinée au centre de la nouvelle n’est pas une construction mélancolique délirante révélant de bonnes qualités de mentalisation comme ce fut par exemple le cas pour Haitzmann rapporté par Freud. C’est au contraire une défaillance de la mentalisation dont Michel Fain démontre l’existence dans les névroses de caractère.

Casimir Bumiller/Bernhard Rüth/Ewin Ernst Weber (Hg.): Mäzene, Sammler, Chronisten. Die Grafen von Zimmern und die Kultur des schwäbischen Adels. Im Auftrag der Landkreise Rottweil und Sigmaringen sowie der Gesellschaft Oberschwaben für Geschichte und Kultur. Stuttgart: Belser 2012; 351 S., ca. 150 farbige Abb., 34,95 EUR

Modern natural products (NPs) research relies on untargeted liquid chromatography coupled with mass spectrometry metabolomics. Together with cutting-edge processing and computational annotation strategies, such approaches can yield extensive spectral and structural information. However, current processing workflows require feature-alignment steps based on retention time which hinders the comparison of samples originating from different batches or analyzed using different instrumental setups. In addition, there is currently no analytical framework available to efficiently match processed metabolomics data and associated metadata with external resources. To address these limitations, we present a new sample-centric and knowledge-driven framework allowing multi-modal data alignment - e.g. through chemical structures, biological activities, or spectral features - and demonstrate its value in exploring large and chemodiverse natural extract datasets. Here, the experimental data is processed at the sample level, matched with external identifiers where possible, semantically enriched, and integrated into a unified knowledge graph. The use of semantic web technology enables comparison of processed and standardized data, information, and knowledge at the repository scale. We demonstrate the utility of the developed framework, the Experimental Natural Products Knowledge Graph (ENPKG), to leverage the results obtained from screening 1,600 plant extracts against trypanosomatids and streamline the identification of new antiparasitic compounds. Thanks to its versatility, the proposed approach allows for a radically novel exploitation of metabolomics data. Semantic web technologies are a fundamental asset and we anticipate that their adoption will complement the current computational metabolomics pipelines and enable the community to advance in the description of global chemodiversity and drug discovery projects.

La transition énergétique est assortie d’une révolution copernicienne dans l’électricité : avec toujours plus de productions renouvelables, intermittentes et décentralisées, assurer l’équilibre entre production et consommation à tout instant requiert désormais de piloter la consommation. C’est l’objet d’un nouveau métier consistant à optimiser en temps réel la consommation de millions d’appareils électriques en les pilotant à distance et de façon coordonnée. La transition énergétique appelle en effet à de fortes évolutions du côté de la consommation, en particulier du fait de « l’électrification des usages », notamment la diffusion des pompes à chaleur et des véhicules électriques. Surgissent ainsi de nouvelles opportunités en matière de pilotage, au bénéfice des consommateurs. Ce pilotage se révèle déjà très précieux dans la crise actuelle, car il a un impact énorme en termes de modération des prix.