Plan International

With the increasing prevalence of polypharmacy, age-related physiological changes, and the need for individualized pharmacotherapy in older patients, understanding new drug approvals is crucial to optimizing medication management. This review synthesizes the latest evidence on recently approved medications including Atzumi™ and Brekiya® (dihydroergotamine mesylate) for migraine headaches, Attruby™ (acoramidis) for transthyretin amyloid cardiomyopathy, and Blujepa® (gepotidacin) for uncomplicated urinary tract infections. Insights are offered into prescribing considerations for these agents in older populations, potential drug-drug interactions, and administration and handling tips. This work will be of significant interest to health care professionals as they evaluate the appropriateness of these new therapeutic options.

Geographic Information Systems (GIS) and spatiotemporal data analysis play a key role in modern agriculture by enabling farmers to make evidence-based decisions.These technologies integrate meteorological data, satellite imagery, and local sensor measurements to provide precise and localized information for planning and executing agricultural operations.This contribution introduces the info4agro.complatform, which helps farmers implement decision-making workflows by providing actionable insights and tools to support key agricultural activities.Through real-world use cases, the contribution demonstrates how this platform enables efficient decision-making, enhances sustainability, and improves productivity.

The Life Care Planning Summit is a biennial event made up and attended by representatives from professional organizations and training programs, researchers, practitioners, and support service providers, to explore the current state and future directions of the specialty practice of life care planning. Although the process of life care planning standards has been established, consensus and unity in the field is a developmental process. Through a series of round table discussions, participants have the opportunity to examine life care planning issues, contribute to the resolutions of these issues, and be involved in the continued evolution of this specialty practice.

Aim: This article aims to highlight the importance of fill rate as an important metric for after-sales performance in the automotive industry and equip manufacturers and service organizations with actionable methods to enhance inventory availability, strengthen customer trust, and build a more resilient after-sales ecosystem. Methods: The article provides a framework for calculating fill rates using transactional data and demonstrates practical examples supported by data visualization developed in the Python programming language. It integrates data-driven analysis with operational insights to help diagnose poor fill rate performance, such as inaccurate demand forecasting, supplier delays, rapid changes in demand, material replenishment planning (MRP) parameter issues, and inventory mismanagement. It also outlines strategies to troubleshoot and improve them. Results: The analysis shows how fill rate can reflect operational efficiency, supply chain agility, and customer-centric service delivery. By applying the calculation methods and visualizations, users can better understand inventory performance patterns, identify bottlenecks, and quantify the impact of the fill-rate variations on service operations and customer experience. Conclusion: Fill rate is one of the most critical indicators in after-sales operations, as it directly influences vehicle downtime, customer satisfaction, brand loyalty, and long-term revenue growth. Ensuring consistently high fill rates demonstrates strong inventory management and operational effectiveness in an increasingly competitive automotive landscape.

Abstract During the NASA Perseverance rover's exploration of the Jezero crater floor, coatings were commonly observed on rocks. These features may record past water‐rock‐atmosphere interactions on the crater floor, and understanding their origin is important for constraining the timing of potential water activity and habitability at Jezero. Here, we characterize the morphologic, chemical, and spectral properties of the crater floor rock coatings using color images, visible/near‐infrared reflectance spectra, and chemical data from the Mastcam‐Z and SuperCam instruments. We show that coatings are common and compositionally similar across the crater floor, and consistent with a mixture of dust, fine regolith, sulfates, and ferric oxides indurated as a result of one or more episodes of widespread surface alteration. All coatings exhibit a similar smooth homogenous surface with variable thickness, color, and spatial extent on rocks, likely reflecting variable oxidation and erosional expressions related to formation and/or exposure age. Coatings unconformably overlie eroded natural rock surfaces, suggesting relatively late deposition that may represent one of the last alteration episodes on the Jezero crater floor. While more common at Jezero, these coatings may be consistent with rock coatings previously observed in situ at other landing sites and may be related to duricrust formation, suggesting a global alteration process on Mars that is not unique to Jezero. The Perseverance rover likely sampled these rock coatings on the crater floor and the results from this study could provide important context for future investigations by the Mars Sample Return mission aimed at constraining the geologic and alteration history of Jezero crater.

As the cradle of Jiangnan culture, Suzhou is home to a dense concentration of historical architectural heritage that is currently facing existential threats from rapid urbanization. This study aims to develop a spatial heritage corridor network for conservation and sustainable utilization. Using kernel density estimation, this study identifies 15 kernel density groups, along with the Analytic Hierarchy Process (AHP), to pinpoint clusters of historical architectural heritage and assess the involved resistance factors. Current Effective Conductance (CEC) theory is further applied to model spatial flow relationships among heritage nodes, leading to the delineation of 27 heritage corridors and revealing a spatial structure characterized by one primary core, one secondary core, and multiple peripheral zones. Based on 15 source points, six cultural relics-themed routes are proposed—three land-based and three waterfront routes—connecting historical sites, towns, and ecological areas. The study further recommends a resource management strategy centered on departmental collaboration, digital integration, and community co-governance. By integrating historical architectural types, settlement forms, and ecological patterns, the research builds a multi-scale narrative and experience system that addresses fragmentation while improving coordination and sustainability. This framework delivers practical advice on heritage conservation and cultural tourism development in Suzhou and the broader Jiangnan region.

Objetives: Despite support for breastfeeding, many mothers are unable to breastfeed as they wish. There are frequent breastfeeding difficulties, feelings of guilt, loneliness and shame, and cessation is sometimes associated with depression. The objective is to conduct a review on the relationship between breastfeeding experiences and maternal mental health and to provide recommendations to professionals and families. Material and methods: a review of the literature published in PubMed (MEDLINE), Cochrane, APA PsycNet, PsycINFO, Enfispo and CINHAL was carried out with the keywords «maternal/motherhood», «experience breastfeeding», «guilt», «anxiety» and «depression». Results: Breastfeeding difficulties, lack of support and early cessation are predisposing factors for maternal depression while satisfactory breastfeeding, skin-to-skin contact and having a social support network are protective. A discordance between expectations and actual experience may be associated with worse maternal mental health. Individualized and multidisciplinary interventions are more successful. Conclusions: The association between breastfeeding and depression or anxiety is inverse and bidirectional and it is influenced by maternal expectations. The postpartum period is a period of special vulnerability, professionals and families should help mothers without judging or negatively influencing their experiences. More research is needed on factors that determine the breastfeeding experience and the effectiveness of interventions. Breastfeeding is not just the option or responsibility of the mother, it is the responsibility of the entire society.

The ocean is brimming with mostly invisible, highly diverse forms of life: plankton. These microscopic organisms play a key role in the health and stability of aquatic ecosystems, and a growing body of evidence highlights their significant impact on global biogeochemical processes and climate regulation. Tracking plankton biodiversity at local, regional and global levels is therefore essential to understand their distribution, evolution and responses to environmental changes, as well as their influence on climate regulation. However, planetary ocean microbiology remains a challenge due to the vast extent of the ocean on one hand, and to the high costs and administrative complexity of oceanographic vessels on the other. In order to unlock a global and continuous measure of plankton, the Plankton Planet initiative, embodied in the Seatizens for Plankton Planet NGO, develops a new generation of cost-effective, robust, simple-to-use instruments and protocols for citizen science, that allow “seatizens” (seafarers eager to observe and better understand the ocean) to measure the genetic and morphological diversity of plankton. At the core of the initiative are world experts in ocean life science, which ensures the scientific quality and relevance of the measures. The instruments, conceived within Plankton Planet and developed by emerging startups, are designed to be used on sailing boats and can be deployed on larger platforms at sea or on shore. The collaborative engagement with “seatizens”, and their training to obtain rigorous and consistent data, is a critical component of the project. This interaction introduces an additional challenge for scientists, who must embrace different mind-sets and develop innovative ways to work and collaborate with non-professional scientists. By engaging “seatizens” in the global monitoring of the aquatic microbiome, the Plankton Planet initiative sets the basis for significantly expanding observations that inform predictive models of the ocean. Microbiodiversity is the ultimate parameter that needs to be integrated into Ocean and Earth system models if we want to better understand and protect planetary health.

BackgroundGlobally, alarmingly high rates of maternal and infant mortality and morbidity persist. A constellation of health system and social factors contribute to this, including poor quality and barriers to accessing health care, including preventive services. As such, there have been calls for a redesign of maternal and child health (MCH) services. Although group care has primarily been tested in antenatal settings, it offers a promising redesign that optimizes maternal and child health care, survival, and well-being. The purpose of this study was to produce a blueprint of an adapted group care model that integrates postnatal maternal care, well-child care, and family engagement to be adapted to realities of different settings.MethodsUsing a human-centered design approach and the Framework for Reporting Adaptations and Modifications to Evidence-based interventions (FRAME), we employed qualitative methods to adapt CenteringParenting® (retaining its three core pillars of health assessment, interactive learning, and community building), and co-create the blueprint for group care beyond birth that can be used across settings. We initiated the process through face-to-face workshops during a global meeting on group care, followed by six online incubator sessions with key stakeholders from 13 countries during which we used qualitative methods of free listing, pile sorting, and ranking. We conducted a rapid qualitative analysis to produce a blueprint.ResultsParticipants collaboratively modified the content, format, and evaluation of CenteringParenting® with the goal of creating a blueprint that integrates postnatal and pediatric care into group care that can be further adapted and implemented across diverse settings and contexts. The blueprint consists of suggested timing of visits over two years after birth, suggested visit content, and evaluation metrics for research and practice.ConclusionsThe resulting group care beyond birth blueprint offers a strategy to redesign maternal and infant/child health services that can positively transform postnatal care and provide essential services to postpartum people. Adaptation of the blueprint to local realities is expected. Future research is recommended to test the model’s acceptability, feasibility, and effectiveness across settings. Using this blueprint, we can build the evidence base to support this model aiming to improve maternal and infant/child health outcomes.