Qiagen (Netherlands)

We previously identified distinct muscle and liver insulin resistance (IR) metabotypes in middle-aged and older adults. The PERSON study showed that a low-fat, high-protein, high-fiber diet benefits the muscle IR group, while a high-monounsaturated fatty acid diet benefits the liver IR group. We also developed the MetaboHealth score, reflecting risks of mortality, frailty, and cognitive decline. This study aimed to examine whether MetaboHealth interacts with IR metabotypes to influence (i) cardiometabolic health and (ii) body composition outcomes in the PERSON study, informing precision nutrition strategies. In total, 242 adults aged 40-75 with IR were randomized to follow an isocaloric low-fat, high-protein, high-fiberor high-monounsaturated fatty acid diet for 12 weeks. Of these, 184 with complete data were grouped into MetaboHealth tertiles (higher = poorer health). Outcomes included a 7-point oral glucose tolerance test and DXA-based body composition. Linear mixed models assessed four-way interactions. No interaction was observed for cardiometabolic outcomes. Significant interactions were found for android, gynoid, total fat percentage, and fat mass index. In the healthiest tertile, matched diets led to greater fat loss. In the poorest tertile, both diets were similarly effective. MetaboHealth remained unchanged. Combining metabotype with MetaboHealth may enhance personalized dietary strategies for fat loss in insulin-resistant adults.

Consumption of sweeteners and sweetness enhancers (S&SEs) is a popular strategy to reduce sugar intake, but the role of S&SEs in body weight regulation and gut microbiota composition remains debated. Here, we show that S&SEs in a healthy diet support weight loss maintenance and beneficial gut microbiota shifts in adults with overweight or obesity. In this multi-centre, randomized, controlled trial, we included 341 adults and 38 children with overweight or obesity. Adults followed a 2-month low-energy diet for ≥5% weight loss, followed by a 10-month healthy ad libitum diet with <10% energy from sugars. One group replaced sugar-rich products with S&SE products (S&SEs group), while the other did not (sugar group). Primary outcomes included changes in body weight and gut microbiota composition at 1 year. Secondary outcomes included changes in cardiometabolic parameters. The S&SEs group, compared to the sugar group, maintained greater weight loss at 1 year (1.6 ± 0.7 kg, P = 0.029) and exhibited distinct gut microbiota shifts, with increased short-chain fatty acid and methane-producing taxa (q ≤ 0.05). No significant differences were observed in cardiometabolic markers or in children. Overall, our findings indicate that prolonged consumption of S&SEs in a healthy diet is a safe strategy for obesity management. ClinicalTrial.gov identifier: NCT04226911.

PurposeConsumption norms describe an individual’s perception of what or how much most other people typically eat. While gendered consumption norms are well known, consumption norms linked to other demographic variables are yet to be reported. This study aimed to investigate which food consumption norms in relation to gender, age and income are currently held by the UK population. A secondary research objective was to investigate whether these consumption norms were held equally across people in different age groups and genders within the sample population.Design/methodology/approachA sample of 498 adults participated in an online survey composed of statements on consumption patterns based on gender, age and income for nine foods (e.g. red meat) and five meal patterns (e.g. take-away meals). E.g. “Men tend to eat more red meat than women.” Participants reported their agreement/disagreement with these statements.FindingsThe results indicate that participants have perceived consumption norms that are associated with gender, age and income. Lower energy-dense foods and smaller meal patterns were generally associated with females, older persons and individuals with a higher income. In contrast, more energy-dense foods and meal patterns were generally associated with males, younger adults and individuals with a lower income. These consumption norms were held consistently across the population sample.Originality/valueTo the best of our knowledge, this is the first explicit demonstration of food consumption norms based on age and income.

This article discusses the document on Ministry and Diversity in the Protestant Church in the Netherlands, which was prompted by the need for innovation, due to the new situation of this Church. The document is based on the importance of the ordination. Previous developments are being described and the new proposals are being weighed up with all the pros and cons. The emphasize is on the importance of the ecumenical discussions on Ministry initiated by the World Council of Churches resulting in the BEM-document (1982) and the theological conversations initiated by the Community of Protestant Churches in Europe, resulting in the MOE-document (2013).

Private food safety standards have become an important governance mechanism in contemporary food supply chains. While much has been written about private standards from the perspectives of different academic fields, there has never been a dedicated literature review to examine their interaction with global food supply chains. In this systematic review, 45 peer reviewed articles on private food standards, selected through extensive searches in four academic databases are critically appraised. Our analysis reveals that the most studied European private food safety standards are owned by retail conglomerates and therefore place the retail sector in a position of influence in the supply chain. These standards influence supply chain structures, market access, and the efficiency of food safety management systems. They also challenge the traditional relationship shared by actors in the supply chain with public authorities and the World Trade Organization. In the recent years, their scope has expanded to include topical issues such as environmental sustainability, worker safety, and animal welfare. Overall, the review suggests that European private food safety standards alter the operations of modern agri-food supply chains to accommodate consumer wishes while allowing the retail sector to exert its influence without taking on additional legal and economic liability.

We present a fast and efficient approach to predict the wettability and spreading of liquids on polymeric substrates. First, a molecular dynamics parameterization is proposed for the calculation of the solubility parameter for 74 compounds including surfactants typically used in inkjet printing. Then, we introduce a molecular geometrical factor to relate the solubility parameter to the surface tension, obtaining estimates in remarkable agreement with experiments. By using a modified Young-Fowkes equation, the contact angles of liquids on various polymeric substrates are determined and their dependence on the hydrogen bonding, dispersion and polar contribution of the solubility parameter are investigated. We find that wetting properties are obtained with a good accuracy when taking into account the hydrogen-bonding and polar interactions in the geometric sum of the solubility parameter. Based on these findings, a 3D wetting space is proposed to evaluate liquids wettability and judge their suitability for specific substrates. This will enable easy formulation of liquids with wettability tailored for a particular surface and application.

Protein- and sugar-rich food products processed at high temperatures contain large amounts of dietary advanced glycation endproducts (dAGEs). Our earlier studies have shown that specifically protein-bound dAGEs induce a pro-inflammatory reaction in human macrophage-like cells. To what extent these protein-bound dAGEs survive the human gastrointestinal (GI) tract is still unclear. In this study we analysed gastric and small intestinal digestion of dAGEs using the validated, standardised TNO in vitro gastroIntestinal digestion model (TIM-1), a dynamic in vitro model which mimics the upper human GI tract. This model takes multiple parameters into account, such as: dynamic pH curves, peristaltic mixing, addition of bile and pancreatic digestive enzymes, and passive absorption. Samples of different digested food products were collected at different time points after (i) only gastric digestion and (ii) after both gastric plus small intestinal digestion. Samples were analysed for dAGEs using UPLC-MS/MS for the lysine derived Nε-carboxymethyllysine (CML) and Nε-carboxyethyllysine (CEL), and the arginine derived methylglyoxal-derived hydroimidazolone-1 (MG-H1), and glyoxal-derived hydroimidazolone-1 (G-H1). All AGEs were quantified in their protein-bound and free form. The results of this in vitro study show that protein-bound dAGEs survive gastrointestinal digestion and are additionally formed during small intestinal digestion. In ginger biscuits, the presence MG-H1 in the GI tract increased with more than 400%. This also indicates that dAGEs enter the human GI tract with potential pro-inflammatory characteristics.

European food law is a newly developing field in which different branches of law come together. The field is however also unmistakably linked with nutritional sciences, in requesting scientific evidence to ensure safety and benefits of foodstuffs. The risk analysis cycle introduced in Regulation (EC) No 178/2002, ensures that scientific information – regarding i.a. the safety of a product – is independently and transparently assessed by risk assessors who are not involved in the final political risk management decision, in which this scientific information is used to allow such a product on the market. The European Food Safety Authority’s mission as assessor is to independently and transparently conduct risk assessments, which are published in scientific opinions. Transparency of both the procedure and of the Authority’s role, key in these assessments, are however two of the shortcomings identified in the evaluation of the Regulation 178/2002 that was conducted recently. In a proposed update of the Regulation, transparency of risk assessment is therefore one of the main aspects to be improved. This originates from the understanding that such improved transparency of the European food safety system will result in increased consumer trust. After shorty reviewing the development of European food law and the proposed adjustments to the framework regulation, this chapter shows that the concept of transparency, mostly understood as increasing the availability of information, requires to be further specified to ensure it actually contributes to consumer trust. The proposed adjustments to the Regulation 178/2002 are expected to increase information availability, whilst improved risk communication strategies might aid in establishing consumer trust. Further specifying the concept of transparency will result in an increased understanding of how to operationalise it and how transparency can contribute to increasing consumer trust.

In this study, we investigated the effect of liquid viscosity and surface tension for inkjet printing on porous cellulose sheets. We used five model liquids, representing the operational field of an industrial high speed inkjet printer, as specified by Ohnesorge- and Reynolds number. Drops with 30 pl and 120 pl drop size were jetted with a commercial HSI printhead. We printed on four uncoated papers representing the most relevant grades on the market in terms of hydrophobisation and surface treatment. We are presenting a quantitative analysis of viscosity and surface tension on the print outcome, evaluating dot size, liquid penetration (print through) and surface coverage of the printed dots. The most important finding is that for liquids within the jetting window the variation of the liquid viscosity typically has a 2–3 times higher impact on the print outcome than variation of the liquid surface tension. Increased viscosity in all cases reduces dot area, liquid penetration and liquid surface coverage. Surface tension plays a smaller role for liquid spreading and penetration, except for hydrophobised substrates, where both are reduced for higher surface tension. Interestingly, higher surface tension consistently increases liquid surface coverage for all papers and drop sizes. A detailed analysis on the competing effect of dot spreading and liquid penetration is presented, in terms of viscosity, surface tension and surface coverage of the liquid.