R.T. Vanderbilt Holding (United States)

To compare survival between gynecologic cancer patients with carboplatin hypersensitivity thereafter managed with carboplatin desensitization, cisplatin replacement, and alternative non-platinum therapy. A retrospective review of patients who experienced a hypersensitivity reaction to carboplatin and were treated at the same comprehensive cancer center between 2010 and 2024 was completed. The primary analysis compared progression-free survival between carboplatin desensitization, cisplatin substitution, and alternative non-platinum therapy patients. Secondary analysis compared survival between platinum therapy and non-platinum alternative therapy patients. Descriptive analysis was further performed to delineate the clinical phenotypes of patients with carboplatin hypersensitivity. There were 47 gynecologic cancer patients with carboplatin hypersensitivity, and 38 patients with known progression-free survival. Progression-free survival was significantly longer in desensitized patients (31.1months) vs. cisplatin patients (22.0months, p=0.045). There were no significant differences in progression-free survival between desensitized (31.3months) and alternative therapy patients (36.0months), as well as platinum (31.1months) and non-platinum-based alternative therapy patients (36.0months). A majority of our cohort was observed to have recurrent disease at the time of hypersensitivity (70.2%), a carboplatin-free interval of 12months or more (57.4%), history of adverse reactions to other drugs (76.6%), advanced stage disease (78.8%), and serous histology (70.2%). Desensitized patients demonstrated increased progression-free survival as compared to cisplatin patients. This progression-free survival advantage may be due to the increased toxicity profiles noted for cisplatin and comparatively better tolerability of carboplatin desensitization. Progression-free survival was similar between carboplatin-desensitized and alternative therapy patients, as well as platinum-based and alternative therapy patients.

The above book published by Professor Joseph Balogun, an accomplished clinician, researcher, educator, and administrator, who doubled as a participant-observer while working on this book, is a compelling masterpiece. As a former Senior Lecturer and Vice-Dean at Obafemi Awolowo University, Ile-Ife three decades ago, a retired Distinguished Professor at Chicago State University, faculty, and administrator at several universities around the world, made Professor Balogun uniquely qualified to author this book. He is familiar with the global education and healthcare systems. As a patriotic Nigerian who has devoted his life to giving back to his homeland, Professor Balogun authored this book to address the curriculum deficits he observed during one of his many visits to Nigeria. At a national workshop he gave at the University of Medical Sciences, Ondo City in 2018 to faculty, heads of academic departments, and university administrators, he observed that most of his audience had no formal training on their roles and responsibilities.

This study is an exploration of lived religion and gender across the Reformation, from the 14th–18th centuries. Combining conceptual development with empirical history, the authors explore these two topics via themes of power, agency, work, family, sainthood and witchcraft. By advancing the theoretical category of ‘experience’, Lived Religion and Gender reveals multiple femininities and masculinities in the intersectional context of lived religion. The authors analyse specific case studies from both medieval and early modern sources, such as secular court records, to tell the stories of both individuals and large social groups. By exploring lived religion and gender on a range of social levels including the domestic sphere, public devotion and spirituality, this study explains how late medieval and early modern people performed both religion and gender in ways that were vastly different from what ideologists have prescribed. Lived Religion and Gender covers a wide geographical area in western Europe including Italy, Scandinavia and Finland, making this study an invaluable resource for scholars and students concerned with the history of religion, the history of gender, the history of the family, as well as medieval and early modern European history. The Introduction of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license and is available here: https://tandfbis.s3-us-west-2.amazonaws.com/rt-files/docs/Open+Access+Chapters/9781351003384_oaintroduction.pdf

Elastohydrodynamic lubrication (EHL) film thickness suggests the capability of a lubricant to support load under a set of hydrodynamic conditions. It is related to the rheological properties of a lubricant, contact geometry, materials properties, and operating conditions such as load, speed, and temperature. Film thickness variation with speed or load may follow the prediction made with the theory of EHL. Experimental techniques based on capacity [1-3]; electrical conductivity and contact resistance [4-6]; discharge voltage [7]; X-ray transmission [8]; indirect laser transmission [9,10]; R-C oscillation technique [11]; and optical interferometry [12–35] have been used in EHL experiments for film- thickness measurement. On the other hand, as a result of the rapid development of high-speed computers, in-depth and detailed numerical analyses of EHL problems intend to become a routine practice. More influential factors can be considered now in EHL calculations: several non-Newtonian properties of a lubricant [30,31,36–38], surface roughness [32,33,37,38], the thermal effect [34,39,40], and non-steady-state transitions [35,41,42] have been included in a number of simulation models. Moreover, mixed lubrication simulations based on digitized real rough surfaces have been conducted in wider ranges of speed and load [36,37]. This section reviews and discusses the existing techniques for EHL film-thickness measurements, views of measurement data, and comparisons of measurement results with EHL simulation solutions.

Recent advances in non-gradient based optimization methods (e.g., Genetic Algorithms, Particle Swarm Optimization) enhanced the abilities of discrete, integer, and mixed optimization problems. However, the very nature of non-gradient based algorithms is that the number of analyses required to get to an optimal solution is several orders of magnitude higher than for traditional gradient based optimization methods or response surface optimization methods, when considering continuous problems. Instead of these approaches we propose to use a response surface approximate optimization method modified to work with discrete design variables. In this case whenever it is required to perform the actual analysis of responses for the purpose of fitting a response surface approximation, the design variables will be converted to corresponding discrete values. Two discretization techniques are proposed. We demonstrate that although lacking global search properties like Genetic Algorithms and Particle Swarm Optimization, the discrete response surface optimization provides a computationally efficient way of improving an initial design and getting into a region of an optimum using only discrete points for analysis.

Branch, Kathleen; Marra, Mary; Reed, Stephanie; Vanderbilt, Marjorie Author Information