Ravimed (Poland)

Introduction: The study will focus on presenting the effects of adequate intake or supplementation of omega-3 fatty acids on patients' perception of menstrual pain. Other known characteristics of these substances will also be presented. Aim of the study: The aim of the study was to demonstrate impact of omega-3 fatty acids supplementation or normal supply to dysmenorrhea among women through a literature review. State of Knowledge: Dysmenorrhea is a condition that limits normal functioning and affects up to 90% of women. Therefore, it is so important to study its pathogenesis and prevent its occurrence. It results in the use of painkillers and the absence of many women from daily activities. Omega-3 acids are polyunsaturated fatty acids that have a positive effect on numerous organs and functions of the human body. They are substances with anti-inflammatory properties, which have been used in research on the influence of omega-3 acids on reducing dysmenorrhea among women. Conclusion: Omega-3 acids reduce dysmenorrhea in women. It is very important to pay attention to the presence of acids in diet as well as supplementation among patients.

Introduction Lactoferrin is a glycoprotein belonging to the group of transferrins found in most body fluids. It has been shown to possess antimicrobial, anti-inflammatory, immunomodulatory and anticancer properties. The increasing availability and widespread use of dietary supplements containing lactoferrin have been observed as supportive measures in managing various infections. Aim of the study The objective of this study is to summarize the current knowledge regarding the anti-infective - mostly antiviral - effects of lactoferrin and the justification for its use in the treatment of upper respiratory tract infections. Knowledge summary Scientific research has consistently confirmed the effectiveness of lactoferrin against pathogenic microorganisms. The antibacterial effect of this protein is based mainly on the management of available iron resources - an ingredient necessary for bacterial growth. On the other hand, the antiviral activity of this protein is based on the induction of interferon production. Conclusion Dietary supplements containing lactoferrin are approved by the US Food and Drug Administration (FDA) for supportive use in infections. Lactoferrin exhibits antimicrobial activity supported by research in specific infections. It has a good tolerance and safety profile, therefore it seems that it can be used adjunctively in this indication.

The correlation between 52 physicochemical parameters and mean residence time (MRT) for 27 drugs used in human and dog were investigated. The physicochemical parameter values calculated provided a basis for deriving a series of arithmetic expressions, which were used to build a mathematical model describing the relationship between them and the MRT values. From the entire set of analyzed parameters, a subset of 14 was identified that contributed to the derivation of an arithmetic expression: Log(PSA - WPSA + ACID) x [XlogP - (LogKp - EAxLn(Caco2 + AMINE + SAF))] + (AMIDE + IP - FG) - Ln(MW + PISA) the value of which is highly correlated with the MRT value in dogs (P < .001) and allowed prediction of the MRT predicted (MRT(pred)). In humans, no correlation was found that allowed the calculation of MRT(pred). These results indicate that predicting the pharmacokinetics of any specific drug for humans based on pharmacokinetic data obtained in the dog should be undertaken with knowledge of the inherent limitations.

The nonlinear response of a three degree of freedom vibratory system with double pendulum in the neighbourhood internal and external resonances is investigated. The equations of motion have bean solved numerically. In this type system one mode of vibration may excite or damp another one, and for except different kinds of periodic vibration there may also appear chaotic vibration. To prove the character of this vibration and to realise the analysis of transitions from periodic regular motion to quasi-periodic and chaotic, the following have been constructed: bifurcation diagrams and time histories, phase plane portraits, power spectral densities, Poincare maps and exponents of Lyapunov. These bifurcation diagrams show many sudden qualitative changes, that is, many bifurcations in the chaotic attractor as well as in the periodic orbits.