History of infection and immunity to rubella.
Freestone, D. S. (Dept. Clinical Immunology, The Wellcome Research Laboratories, Beckenham, Kent, BR3 3BS, England), D. F. Rowlands and J. Prydie. History of infection and immunity to rubella. Am J Epidemiol. 96: 70–73, 1972.—In 13-year-old schoolgirls, good correlations were found between a recent history of rubella and the presence of hemag-glutinating inhibiting (HI) antibody, but the correlations declined progressively as the history of rubella became more remote. These findings suggest a progressive fall in antibody titer, or diminished historical accuracy with passage of time. However, the lower geometric mean HI antibody titers in those groups of girls with less recent histories of infection support the first probability. Furthermore, in seronegative schoolgirls with a history of rubella more than four years earlier, the seroconversion rate to subcutaneously administered live attenuated rubella vaccine was lower than that seen in seronegative girls with no past history of rubella.
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