Research Data Alliance

Emerging from the European Open Science Cloud (EOSC), the FAIRsFAIR project aimed at supplying practical solutions for the use of FAIR data principles throughout the research data life cycle, and in particular fostering FAIR data culture and the uptake of good practices in making data FAIR. Within that context of FAIRsFAIR project, WP6’s main objective was particularly concerned with addressing the effective support of FAIR uptake by engaging with communities through the establishment of a FAIR Competence Centre whose activities were mapped along the trinary: Advisory, Harmonisation, and Dissemination. The output of WP6 is contained in deliverables that report on the journey towards its main objective, including the tasks leading from the development of concepts to their implementation and practical operations. The first deliverable D6.1 (Herterich, P. et al. , 2019) explored the Overview of needs for competence centres; the second, D6.2 (Newbold, E. et al, 2021) developed concepts in the Initial core competence centre structures while the third, D6.3 (Kayumbi, G. et al, 2021) reported on practical operations in Established competence centre for variety of communities. The present deliverable D6.4 Final report for competence centre and knowledge base reports on the tasks accomplished by WP6 in the final stage of project and offers a comprehensive perspective on the work conducted.

Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction () and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms. In this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included interleukin-6 (IL-6), prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and β-hexosaminidase (β-hex). Our data revealed that CITE inhibited the production of IL-6, PGD2, LTC4, and β-hex induced by PMA plus A23187 (P<0.05). These findings indicate that CITE has the potential for use in the treatment of allergy.