Rochdale Infirmary

ABSTRACT The United Nations Sustainable Development Goals (SDGs) provide an integrated framework for embedding social value in infrastructure planning and promoting inclusive, climate‐resilient urban development. However, the operationalization and measurement of social sustainability across infrastructure projects remain inconsistent and underdeveloped. This study examines the relationship between community engagement practices and social value outcomes in flood alleviation schemes in the North of England, with reference to SDG 9 (Industry, Innovation and Infrastructure), SDG 10 (Reduced Inequalities), SDG 11 (Sustainable Cities and Communities), SDG 13 (Climate Action), and SDG 17 (Partnerships for the Goals). Through a comparative case study analysis of the Didsbury, Ripon, and Todmorden flood alleviation schemes, and 33 semi‐structured interviews with practitioners, the research finds that projects characterized by meaningful, early‐stage engagement and knowledge co‐production achieved stronger alignment with local social value priorities and increased community trust. The study concludes that, whereas current practices often reduce social value to narrow economic or technical metrics, embedding co‐production of knowledge with local communities is essential to achieving meaningful social value and aligning with multiple SDGs in flood risk management and infrastructure development.

Reliable estimates of aquifer properties are needed for groundwater resources management and for engineering applications. Pumping tests conducted in fractured aquifers using an open borehole may not produce a proper characterization of the aquifer properties leading to the failure of engineering solutions. In this work, we apply a radial flow model to reproduce the time drawdown curves recorded at an observation borehole instrumented with multi-level piezometers drilled in the Permo-Triassic sandstone, which is a complex fractured hydraulic unit. The radial flow model and the optimization code PEST are used to estimate the aquifer hydraulic parameter values. The model is then used to investigate the implications of replacing the multi-level piezometers with an open borehole. The results show that the open borehole does not only significantly alter the groundwater head and flow patterns around the borehole, but the analysis of the time drawdown curve obtained would produce estimates of aquifer properties that bear no relationship with the actual hydraulic properties of the aquifer. For engineering control studies, the pumping test must be carefully designed to account for the presence of fractures, and these must be represented in the analysis tools to ensure the correct characterization of the hydraulic system.

Abstract Dust stop seals are widely used in powder and rubber mixing industries. Design of the sealing system requires a continuous supply of pressurised lubricant, which is not recycled because of the risk of contamination. There is also the potential of large volume leakage of oil due to poor sealing, increasing operational costs and necessitating remedial measures to avoid environmental protection. Furthermore, the seal faces are prone to failure in relatively short periods of time due to reduced gap and lubricant leakage. The paper presents an analytical method and numerical predictions based on Reynolds equation under combined hydrodynamic and hydrostatic conditions with the entrant lubricant through hydraulically loaded feedholes. The validity of these methods is ascertained through comparison with a more complex but time‐consuming solution of Navier–Stokes equations. The numerical predictions allow for determining the prevailing tribological contact conditions and assessing its suitability for evaluating the sealing performance of mixing machinery.

ABSTRACT Purpose To report a case of bilateral marginal corneal infiltration upon treatment with trastuzumab, pertuzumab, and docetaxel via novel proposed mechanisms. Case description A patient, diagnosed with metastatic breast cancer and positive for human epidermal growth factor receptor 2 (HER2) with high Ki67, presented with bilateral severe marginal corneal infiltration upon undergoing first cycle of triple chemotherapy: trastuzumab, pertuzumab, and docetaxel. Treatment with topical corticosteroids and antibiotics was unsuccessful and was replaced by allogeneic serum eye drops (SED). The case improved significantly 10 days upon starting allogeneic SED. Conclusions We propose that trastuzumab, pertuzumab, and docetaxel suppress HER2 and Ki67 in the cornea and lacrimal gland. To the best of our knowledge, our report is the first to highlight the potential impact of this triple chemotherapy on the lacrimal gland and cornea and the first to highlight the proposed role of Ki67 suppression in damaging corneal integrity.

Version 7.2.0 <p><code>drake</code> version 7.2.0 is being released early in order to ensure compatibility with development <code>testthat</code>, re <a href="https://github.com/ropensci/drake/issues/849">https://github.com/ropensci/drake/issues/849</a>.</p> Mildly breaking changes <ul> <li>In the DSL (e.g. <code>drake_plan(x = target(..., transform = map(...)))</code> avoid inserting extra dots in target names when the grouping variables are character vectors (<a href="https://github.com/ropensci/drake/issues/847">#847</a>). Target names come out much nicer this way, but those name changes will invalidate some targets (i.e. they need to be rebuilt with <code>make()</code>).</li> </ul> Bug fixes <ul> <li>Use <code>config$jobs_preprocess</code> (local jobs) in several places where <code>drake</code> was incorrectly using <code>config$jobs</code> (meant for targets).</li> <li>Allow <code>loadd(x, deps = TRUE, config = your_config)</code> to work even if <code>x</code> is not cached (<a href="https://github.com/ropensci/drake/issues/830">#830</a>). Required disabling <code>tidyselect</code> functionality when <code>deps</code> <code>TRUE</code>. There is a new note in the help file about this, and an informative console message prints out on <code>loadd(deps = TRUE, tidyselect = TRUE)</code>. The default value of <code>tidyselect</code> is now <code>!deps</code>.</li> <li>Minor: avoid printing messages and warnings twice to the console (<a href="https://github.com/ropensci/drake/issues/829">#829</a>).</li> <li>Ensure compatibility with <code>testthat</code> >= 2.0.1.9000.</li> </ul> New features <ul> <li>In <code>drake_plan()</code> transformations, allow the user to refer to a target's own name using a special <code>.id_chr</code> symbol, which is treated like a character string.</li> <li>Add a <code>transparency</code> argument to <code>drake_ggraph()</code> and <code>render_drake_ggraph()</code> to disable transparency in the rendered graph. Useful for R installations without transparency support.</li> </ul> Enhancements <ul> <li>Use a custom layout to improve node positions and aspect ratios of <code>vis_drake_graph()</code> and <code>drake_ggraph()</code> displays. Only activated in <code>vis_drake_graph()</code> when there are at least 10 nodes distributed in both the vertical and horizontal directions.</li> <li>Allow nodes to be dragged both vertically and horizontally in <code>vis_drake_graph()</code> and <code>render_drake_graph()</code>.</li> <li>Prevent dots from showing up in target names when you supply grouping variables to transforms in <code>drake_plan()</code> (<a href="https://github.com/ropensci/drake/issues/847">#847</a>).</li> <li>Do not keep <code>drake</code> plans (<code>drake_plan()</code>) inside <code>drake_config()</code> objects. When other bottlenecks are removed, this will reduce the burden on memory (re <a href="https://github.com/ropensci/drake/issues/800">#800</a>).</li> <li>Do not retain the <code>targets</code> argument inside <code>drake_config()</code> objects. This is to reduce memory consumption.</li> <li>Deprecate the <code>layout</code> and <code>direction</code> arguments of <code>vis_drake_graph()</code> and <code>render_drake_graph()</code>. Direction is now always left to right and the layout is always Sugiyama.</li> <li>Write the cache log file in CSV format (now <code>drake_cache.csv</code> by default) to avoid issues with spaces (e.g. entry names with spaces in them, such as "file report.Rmd")`.</li> </ul>

Veterinary RecordVolume 183, Issue 5 p. 163-164 Letters and notices Reducing plastic waste D. Nigel Griffiths, Corresponding Author griffiths_nigel@hotmail.com Kingsway Retail Park, Wallhead Road, Rochdale, Lancashire, OL16 5AFe-mail: griffiths_nigel@hotmail.comSearch for more papers by this author D. Nigel Griffiths, Corresponding Author griffiths_nigel@hotmail.com Kingsway Retail Park, Wallhead Road, Rochdale, Lancashire, OL16 5AFe-mail: griffiths_nigel@hotmail.comSearch for more papers by this author First published: 04 August 2018 https://doi.org/10.1136/vr.k3317Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume183, Issue5August 2018Pages 163-164 RelatedInformation

The aim of this study was to examine prevalence and associations for use of CAM among People diagnosed with, or with a family risk for CHD in the 6th Troms Study. Methods A total of 12982 men and women (response rate 65.7%) filled in a selfadministrated questionnaire with questions about life style and health issues. Eight hundred and thirty of those had been diagnosed with either heart attack and/or angina pectoris while 4830 had a family risk for such disease due to close family members diagnosed with such disease. Results CAM use (CAM provider, OTC CAM products and/or CAM techniques) was found in 30.2% of the participants diagnosed with CHD and 35.8% of the participants with family risk of CHD (p < 0.001). Selfrated health, expectations for future health, preventive health beliefs and health behaviour were significant predictors of CAM use for those at risk of CHD. In the CHD patient group only health behaviour and self-rated health were significantly associated with CAM use.

To scrutinize the rapid development of robotic versus traditional laparoscopic technique in pelvic urologic surgery. In the last few decades, advances in research and development have led to tremendous progress in medical diagnostics and treatment of disease. Minimally invasive surgery has moved from experimental to becoming the dominant form of surgical management across the surgical specialties. Laparoscopy is nowadays used widely in abdominal surgery, from simple diagnostic laparoscopy to complex colorectal and gynecologic cancer procedures. A literature search of electronic databases (PubMed, Medscape, Embase) using the key words: "pelvic laparoscopy, urologic oncology, robotic surgery, minimally invasive access" was performed for all relevant articles in the English language. Data were extrapolated from the abstracts alone to avoid subjective bias in drawing conclusions. Telemedicine and telesurgery, the diagnostic and operative process is conducted from a distance. The surgeon uses computer-assisted surgery away from the bedside via a robotic system and performs the surgical task at hand. In pelvic urological cancer surgery the use of robotic technique expands to female and reconstructive procedures as well. The leap forward is so massive, that traditional laparoscopic surgery is starting to be considered less, with a growing number of organizations being now more interested in developing a robotic service. Minimally invasive surgical techniques aim to improve surgical outcome in conjunction with delivery of high-quality patient care. Quality studies demonstrating superiority and cost effectiveness are lacking, however. Although tremendous accomplishments took place over a few years, there is still a lot of ground to be covered in standardizing the learning process and evaluating the outcome from the application of new technologies in the field of robotic pelvic surgery.

To investigate whether nursing/care home staff regard pressure ulceration as a safeguarding issue; and to explore reporting mechanisms for pressure ulcers (PUs) in nursing/care homes. Within one clinical commissioning group, 65 staff members from 50 homes completed a questionnaire assessing their experiences of avoidable and unavoidable PUs, grading systems, and systems in place for referral to safeguarding teams. Understanding of safeguarding was assessed in depth by interviews with 11 staff members. Staff observed an average of 2.72 PUs in their workplaces over the previous 12 months, judging 45.6% to be avoidable. Only a minority of respondents reported knowledge of a grading system (mostly the EPUAP/NPUAP system). Most respondents would refer PUs to the safeguarding team: the existence of a grading system, or guidance, appeared to increase that likelihood. Safeguarding was considered a priority in most homes; interviewees were familiar with the term safeguarding, but some confusion over its meaning was apparent. Quality of written documentation and verbal communication received before residents returned from hospital was highlighted. However, respondents expressed concern over lack of information regarding skin integrity. Most staff had received education regarding ulcer prevention or wound management during training, but none reported post-registration training or formal education programmes; reliance was placed on advice of district nurses or tissue viability specialists. Staff within nursing/care homes understand the fundamentals of managing skin integrity and the importance of reporting skin damage; however, national education programmes are needed to develop knowledge and skills to promote patient health-related quality of life, and to reduce the health-care costs of pressure damage. Further research to investigate understanding, knowledge and skills of nursing/care home staff concerning pressure ulcer development and safeguarding will become increasingly necessary, as levels of the older population who may require assisted living continue to rise.