Royal College of Veterinary Surgeons

Rail-Mounted Gantry (RMG) cranes are complex lifting systems widely used in container terminals and industrial sites to ensure the safe handling of heavy loads in both horizontal and vertical planes. One of the main subsystems of these cranes is the trolley , which operates in conjunction with the spreader responsible for carrying and transferring the load. In recent years, designs incorporating 360° rotatable spreader mechanisms have provided significant flexibility in load positioning but have also introduced complex stress distributions in connection regions. In this study, the structural behavior of the spreader component of an RMG-type portal crane was analyzed using the Finite Element Method (FEM). The investigation covered static, buckling, and fatigue strength assessments, with all calculations performed in accordance with DIN EN 13001-3-1+A2 and EN 13001-3-8 standards. During the modeling phase, the steel framework of the spreader structure, along with its welded and bolted joints, was represented in detail. Separate loading scenarios were established for different spreader configurations (rotated positions of 0°, 45°, and 90°), and lifting loads, wheel reaction forces, and boundary conditions were applied in compliance with relevant standards. The analysis results showed that the maximum Von Mises stresses remained below the material yield limit, and the fatigue strength in critical connection areas (such as drum plates, connecting bolts, and weld seams) satisfied the S6 stress range class requirements. Furthermore, the deformations observed in the spreader were within allowable limits, confirming that the structure possessed adequate rigidity against buckling. In conclusion, the RMG portal crane design equipped with a 360° rotatable spreader system was found to be structurally safe in terms of both static and fatigue performance, demonstrating compliance with international standards. This study contributes to the engineering-level optimization of spreader–trolley interaction in next-generation RMG crane systems.

Cervical cancer is a major health concern in Nigeria, where it is one of the primary causes of cancer-related deaths among women. Despite the crucial role of radiation therapy in treating cervical cancer, many patients in Nigeria do not complete their prescribed treatment courses. This review examines the barriers contributing to this issue. Factors such as low awareness and utilization of Pap smears, inadequate HPV vaccination, financial constraints, insufficient radiotherapy infrastructure, and the psychological burden of cancer treatment are explored. Limited screening and vaccination efforts exacerbate the high incidence of cervical cancer in Nigeria. Financial barriers are a primary obstacle, with many patients unable to afford the high cost of radiotherapy. Nigeria's radiotherapy infrastructure is severely lacking leading to significant treatment delays and cancellations. Geographical barriers further complicate access, as many patients must travel long distances to reach treatment centers. Psychosocial issues, including anxiety and depression, significantly impact treatment adherence and completion. These psychological factors, coupled with the physical side effects of radiotherapy, contribute to high rates of treatment interruption. To address these challenges, the review suggests enhancing cervical cancer prevention through increased human papillomavirus (HPV) vaccination and screening, expanding radiotherapy capacity by increasing the number of treatment centers, and providing comprehensive support systems to address financial and psychosocial barriers. By implementing these strategies, it is possible to improve treatment adherence and outcomes for cervical cancer patients in Nigeria.

Cell culture is a critical platform for numerous research and industrial processes. However, methods for transporting cells are largely limited to cryopreservation, which is logistically challenging, requires the use of potentially cytotoxic cryopreservatives, and can result in poor cell recovery. Development of a transport media that can be used at ambient temperatures would alleviate these issues. In this study, we describe a novel transportation medium for mammalian cells. Five commonly used cell lines, (HEK293, CHO, HepG2, K562, and Jurkat) were successfully shipped and stored for a minimum of 72 hours and up to 96 hours at ambient temperature, after which, cells were recovered into standard culture conditions. Viability (%) and cell numbers, were examined, before, following the transport/storage period and following the recovery period. In all experiments, cell numbers returned to pretransport/storage concentration within 24-48 hours recovery. Imaging data indicated that HepG2 cells were fully adherent and had established typical growth morphology following 48 hours recovery, which was not seen in cells recovered from cryopreservation. Following recovery, Jurkat cells that had been subjected to a 96 hours transport/storage period, demonstrated a 1.93-fold increase compared with the starting cell number with >95% cell viability. We conclude that CellShip® may represent a viable method for the transportation of mammalian cells for multiple downstream applications in the Life Sciences research sector.

Limited research on the gross anatomy of the blood vessels has been conducted on hylobatids, or lesser apes, so far. Here, we present a detailed study of the arteries of siamangs (Symphalangus) and compare our findings with data compiled from our previous studies as well as from the literature about other hylobatids, greater apes, and humans. In particular, a three-dimensionalfull-body computed tomography data set of a siamang neonate was analyzed in detail for this study, with notable findings in the head and neck, thorax, upper limb, abdomen and pelvis, and lower limb. Of the 62 arteries that we studied in detail, a total of 20 arteries that have never been described in detail in hylobatids are reported in this study. Key similarities to other apes differing from humans include the existence of a humeral common circumflex trunk and the origination of the dorsalis pedis from the posterior tibial artery or saphenous artery instead of the anterior tibial artery. Similarities to humans differing from other apes include the separation of the lingual and facial arteries and the origination of the profunda brachii from the brachial artery instead of the axillary artery. Our research and broader comparisons, therefore, contribute to knowledge about the soft tissues of hylobatids, other apes, and primates in general and facilitate a better understanding of the anatomical evolution and key differences and similarities among these taxa.