Saab (Switzerland)

Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but the cargo and auxiliary lipids that facilitate the transfer of the majority of LTPs remain unknown. Here we combined biochemical, lipidomic and computational methods to systematically characterize LTP-lipid complexes4 and measure how LTP gains of function affect cellular lipidomes. We identified bound lipids for around half of the hundreds of LTPs that we analysed, confirming known ligands and identifying new ones across most LTP families. Gains in LTP function affected the cellular abundance of both their known and newly identified lipid ligands, indicating comparable functional relevance of the two ligand sets. Using structural bioinformatics, we characterized mechanisms that contribute to lipid selectivity and identified preferences based on headgroup or acyl chain. We demonstrate some basic principles of how LTPs mobilize their ligands. They commonly interact with several classes of lipids and exhibit broad but selective preference for particular headgroups and for lipid species with shorter acyl chains that contain one or two unsaturated carbons, suggesting that only subsets of lipid species are efficiently mobilized. The datasets represent a resource for further analysis in different cell types and states, such as those associated with pathologies.

Abstract Pulp fiber lengths are important in the mechanical behavior of paper and paperboard materials. The length affects the total number of bond sites in fiber networks and thus indirectly the paper strengths. In a case study at Mölnbacka Sweden, fiber lengths of wood samples from 38-year-old trees of Norway spruce (Picea abies) with fast height growth were investigated. The fiber length of the samples was compared with literature values, and some reference example material. The hypothesis was that the sampled trees with fast height growth may have longer fibers, and thus provide longer pulp fibers, compared to lengths previously reported. The work highlights and critically examines the impact of different preparations, measurements, and analysis methods of fiber lengths. The results from this study show that the 21-year-old sampled wood had longer fibers than expected when compared to previous reports for Norway spruce wood grown in Sweden. The samples also showed to have skewed distributions with proportionally more long fibers than expected, also shown by higher mode values to describe central tendencies. About 75 % of the manually measured Mölnbacka fibers were longer than 3.1 mm with a mode value of 3.77 mm.

to provide the epidemiological framework of those affected by rare diseases resident in the Campania Region (Southern Italy), using the data entered in the Campania Region Rare Disease Registry, acquiring information potentially useful for regional planning. observational retrospective cohort study on patients with rare diseases included in the Regione Campania Rare Disease Registry from 01.01.2022 to 31.12.2022. population included in the Rare Disease Registry and resident in the Campania Region as at 31.12.2022. using the data entered in the Regione Campania Rare Disease Registry, the cumulative incidence (I) of patients with rare diseases resident in Campania was calculated, stratified by age group and rare disease group with the respective 95% confidence intervals (IC95%). Standardised cumulative provincial incidences were also calculated. These are reported using a multiplication factor of 100,000. the incidence of patients with rare diseases in the Campania Region is 50.0 (IC95% 49.4-50.6) per 100,000 inhabitants in the year 2022. Furthermore, the rare disease groups with the highest incidence per 100,000 inhabitants are diseases of the central and peripheral nervous system (I: 8.32 per 100,000 inhabitants) and congenital malformations, chromosomopathies and genetic syndromes (I: 8.52 per 100,000 inhabitants). Moreover, the age groups in which the incidence is highest are in the paediatric age group. an epidemiological framework of the Campania Region on rare diseases such as this one for the year 2022 is fundamental for national and regional planning in order to improve the care and quality of life of people affected by rare diseases, who often feel neglected by society. Sharing this type of information also draws attention to the need for faster diagnosis and the specialisation of new centres.

A Saab Sabertooth autonomous underwater vehicle (AUV) was deployed in Lake Michigan at the beginning of meteorological winter successfully navigating from NOAA's Great Lakes Environmental Research Laboratory's (GLERL) Lake Michigan Field Station through the Port of Muskegon pier heads. After an offshore data collection demonstration, the AUV returned to a docking station for recharge and data transfer. Winter ecosystem observations in the Laurentian Great Lakes are difficult to obtain relative to summer open‐water periods as research vessels are not designed for winter operations in ice cover and during vessel icing conditions. In response, capabilities are being developed using uncrewed technologies for winter and under-ice physical, chemical, and biological measurements. Team members included representatives from NOAA, Hibbard Inshore, Saab, the Cooperative Institute for Great Lakes Research, the USGS Great Lakes Science Center, and Teledyne Energy Systems. Development is being performed in three phases: Phase I demonstrated autonomy and limited data collection (accomplished June 2022), Phase II demonstrated fully autonomous navigation, offshore data collection, autonomous docking, and partial data transfer into GLERL's Real-time Coastal Observation Network (ReCON) node at Muskegon MI (accomplished December 2022) , and phase III will include routine operational data collection in winter and under ice with a fully integrated docking, charging, and data transfer station.

To compare clinical and radiographic outcomes of propensity-matched patients undergoing THA using standard versus high offset stems at fiveyears. The authors retrospectively reviewed a consecutive series of primary THAs performed between 01/09/2015-31/12/2017 using a fully-hydroxyapatite coated collared stem, with either a standard (n = 365) or high (n = 110) offset. Outcomes collected included: modified Harris Hip Score (mHHS), Oxford Hip Score (OHS), Forgotten Joint Score (FJS), and radiographic measurements including limb length discrepancy (LLD), stem subsidence, and stem radiolucencies. Propensity score matching resulted in 80 hips per group. Preoperatively there were no significant differences in patient demographics, surgical data and radiographic measurements, except the standard offset group had significantly smaller femoral (40.0 ± 7.5 vs 48.4 ± 6.2, p < 0.001), acetabular (92. ± 6.3 vs 94.8 ± 7.3, p = 0.011) and global (132.0 ± 10.3 vs 143.2 ± 8.2, p < 0.001) offsets compared to the high offset group. At a minimum fiveyears follow-up, there were no significant differences in mHHS (93.2 ± 11.0 vs 93.1 ± 10.6, p = 0.553), OHS (45.1 ± 4.1 vs 45.3 ± 4.6, p = 0.623), and FJS (85.1 ± 19.3 vs 82.7 ± 23.0, p = 0.910). There were also no differences in radiographic measurements, including LLD (1.5 ± 4.8 vs 1.1 ± 3.5, p = 0.537), stem subsidence (0% vs 0%, p = 1.000), and stem radiolucencies (severe: 6% vs 1%, p = 0.152). The present matched-cohort study found no significant differences between standard versus high offset straight fully-hydroxyapatite coated collared stems for primary THA in terms of clinical and radiographic outcomes at fiveyears. These findings may suggest that uncemented collared high offset stems are not associated with an increased risk of radiolucencies and loosening compared to uncemented collared standard offset stems.