Schlumberger (France)

International audience

To analyse at our institution the criteria for selecting a first-line therapy for patients with advanced radioiodine-refractory thyroid cancer and their clinical responses, safety and survival outcomes. We extracted data from 69 consecutive patients referred to Federico II University Hospital from September 2016 to September 2024, among whom 44 patients were treated with TKIs as first-line treatment and outside any clinical trial, and form the basis of this report. Thirty-one (71%) patients were treated with the antiangiogenesis inhibitor lenvatinib and 13 (29%) were treated with selective tyrosine kinase inhibitors (s-TKIs). Among the latter, eight patients were treated with dabrafenib + trametinib (DT), two patients were treated with selpercatinib because of contraindications to lenvatinib, and three patients received DT as redifferentiation therapy. A RECIST partial response was observed in 28% of patients treated with lenvatinib, in 63% of those treated with DT and in one of the two patients treated with selpercatinib. Grade ≥3 adverse events occurred in 13 (42%) patients treated with lenvatinib and only in 1 (9%) patient treated with DT. Progression-free survival (PFS) and overall survival rates at 1 year were 72% and 83% in lenvatinib-treated patients and 69% and 83% in DT-treated patients, respectively. In both selpercatinib-treated patients, the PFS at data cut-off was 10 months. No treatment-related deaths were observed. S-TKIs permitted tailoring systemic treatment based on disease location, tumour volume and patient comorbidities, achieving satisfactory tolerance and outcomes in selected patients with an actionable driver mutation and with contraindications to angiogenesis inhibitors or candidates for redifferentiation therapy.

The present paper consists in two parts, determined by the historical emerging production of Dipole Sonic Imager (DSI) measurements and results in the early 1990’s. The DSI data were processed following two methods simultaneously developed in France and in USA by Schlumberger. In the first part the early dipole sonic S-wave velocity results obtained in late 1993 are confronted with the other borehole data obtained in the scientific borehole MM-1, entirely cored and extensively logged, as part of the comprehensive scientific project named Géologie Profonde de la France (GPF), conducted by the Bureau de Recherches Géologiques et Minières (BRGM, i.e. the French Geological Survey), in Ardèche, southern France. In 1994, José Perrin summarized and integrated all the borehole information including the preliminary results from an azimuthal “rotation scan” of S-wave sonic slowness determination method quickly developed in Schlumberger-France and aiming at detecting only the presence of S-wave velocity anisotropy in a first step. The initial results were presented to the French industrial logging community in April 1994, prior to the commercialization of any S-wave splitting computer detection routine applied to dipole sonic data. The second part focuses on the comparison of the dipole sonic S-wave anisotropy detection results from two methods produced at a later time by Schlumberger, namely: a) results from the commercial S-wave anisotropy detection routine based on cross energy minimization, obtained in October 1994, and b) principal S-wave azimuth results sorted from the “rotation scan” azimuthal method, produced in 1995 and further improved in July 1997. After discussing the discrepancies of the principal fast S-wave azimuth derived from the two methods with diverse specialists in Schlumberger, over several years, and on a spare time basis, the authors expose constructive explanations in the present paper. A limited overview of the latest dipole sonic data processing developments has also been attempted to better understand the differing S-wave birefringence results obtained in MM-1, suggesting that the rock formation in the immediate borehole vicinity, up to three times the borehole radius, may not be homogeneous along the borehole depth depending on the local geological context. Besides, the Fast Azimuth split S-wave (FAZ) fits with the strike of major regional faults and parallel to the maximal horizontal palaeo-stress, which happens to be nearly orthogonal to the local present stress direction accepted by the geologists! The present case study suggests that the S-wave anisotropy results ought to become more reliable, mainly on the accuracy and precision of the FAZ. Additionally, the efficiency of the semblance parameter for S-wave attenuation anisotropy detection is pondered, where no S-wave velocity anisotropy is detected over the dipole sonic receiver array.

<p>The Alpine Fault at the West Coast of the South Island (New Zealand) is a major plate boundary that is expected to rupture in the next 50 years, likely as a magnitude 8 earthquake. The Deep Fault Drilling Project (DFDP) aimed to deliver insight into the geological structure of this fault zone and its evolution by drilling and sampling the Alpine Fault at depth. Here we present results from a seismic survey around the DFDP-2 drill site in the Whataroa Valley where the drillhole almost reached the fault plane. This unique 3D seismic survey includes several 2D lines and a 3D array at the surface as well as borehole recordings. Within the borehole, the unique option to compare two measurement systems is used: conventional three-component borehole geophones and a fibre optic cable (heterodyne Distributed Vibration Sensing system (hDVS)). Both systems show coherent signals but only the hDVS system allowed a recording along the complete length of the borehole.</p><p>Despite the challenging conditions for seismic imaging within a glacial valley filled with sediments and steeply dipping valley flanks, several structures related to the valley itself as well as the tectonic fault system are imaged. The pre-processing of the seismic data also includes wavefield separation for the zero-offset borehole data. Seismic images are obtained by prestack depth migration approaches.</p><p>Within the glacial valley, particularly steep valley flanks are imaged directly and correlate well with results from the P-wave velocity model obtained by first arrival travel-time tomography. Additionally, a glacially over-deepened trough with nearly horizontally layered sediments is identified about 0.5 km south of the DFDP-2B borehole.</p><p>With regard to the expected Alpine fault zone, a set of several reflectors dipping 40-56° to the southeast are identified in a ~600 m wide zone between depths of 0.2 and 1.2 km that is interpreted to be the minimum extent of the damage zone. Different approaches image one distinct reflector dipping at 40°, which is interpreted to be the main Alpine Fault reflector. This reflector is only ~100 m ahead from the lower end of the borehole. At shallower depths (z<0.5 km), additional reflectors are identified as fault segments and generally have steeper dips up to 56°. About 1 km south of the drill site, a major fault is identified at a depth of 0.1-0.5 km that might be caused by the regional tectonics interacting with local valley structures. A good correlation is observed among the separate seismic data sets and with geological results such as the borehole stratigraphy and the expected surface trace of the fault.</p><p>In conclusion, several structural details of the fault zone and its environment are seismically imaged and show the complexity of the Alpine Fault at the Whataroa Valley. Thus, a detailed seismic characterization clarifies the subsurface structures, which is crucial to understand the transpressive fault’s tectonic processes.</p>

Organic fertilization involves working with machines by a special construction, suitable for the material to be spread, machines that have, in most cases, chain conveyors with scrapers attached to the chains. In some cases, the conveyor chain may break, due to the jams, and the need for manual unloading of the bunker (bucket) appears, which requires a great physical effort, the unloading being made by the operator, using a shovel. The construction of the platform using mobile, articulated elements would greatly facilitate the unloading at the bottom of the bunker and would eliminate the physical effort of the operator. This article presents the structural, kinematic and kinetostatic analysis of a mechanism designed for actuating a mobile platform, which is part of a manure spreader, composed of articulated elements driven by hydraulic cylinders. For the kinematic analysis of the mobile element platform’s mechanism, calculation procedures written in the Matlab syntax are used. After the kinematic analysis of the mechanism, the kinetostatic analysis is performed, i.e. the determination of the reactions from the kinematic couplings, as well as the hydraulic force from the hydraulic cylinder. The results can be used for dimensional verification of the mechanism components, thus contributing to the optimization of the mechanism.

An authentication model using secured smart cards implementing IP services is presented. In this model, some authentication functions usually found in the access network are moved inside the smart card. This innovative architecture simplifies current authentication schemes and helps to design new services.