Sema Construction (United States)

Background. There is a complex interaction of endogenous and exogenous factors in rosacea pathogenesis. Existing methods of analysis often do not consider the multifactorial nature of dermatosis, which complicates effective management of patients. Objective. To identify the main relationships between the development factors and rosacea severity building a Bayesian network model original for this dermatosis, as well as to evaluate the results of topical therapy with metronidazole. Material and methods. The study was performed from 2023 to 2025 in Kazan. It involved 117 patients with papulopustular rosacea, median age 35.0 [24; 45] years. The studied parameters included: unchangeable (general characteristics, anamnestic data) and changeable (laboratory indicators, morphofunctional parameters and microbiota content of the facial skin) factors. Obtained parameters — clinical characteristics and dermatological indices. At the first stage of the study, a reconstruction of non-parametric Bayesian network was carried out using a modified algorithm that ensures reproducibility of the model due to clear threshold criteria (Spearman’s rank correlation coefficient equal 0.7 and above) and cycle elimination stages. At the second stage, a group of patients (n=52) with papulopustular subtype of rosacea of mild and moderate course was formed from the total sample, and these subjects underwent 12-week topical therapy with 1% metronidazole gel. Results. With the use of a new network approach for rosacea, key factors influencing the course of dermatosis were identified, 4 clusters of features describing the influence of hormonal, biochemical, immunohematologic and microbial pathogenesis factors were formed. Topical therapy of patients (n=52) with 1% metronidazole gel was effective in 86.5% (n=45) cases. Adverse local reactions were characterized by a mild degree of severity and did not require withdrawal of the drug. Conclusion. The proposed multicomponent Bayesian rosacea model with methodological reproducibility is useful for understanding the relationships between pathogenesis factors and clinical manifestations of dermatosis. Topical therapy of papulopustular rosacea with 1% metronidazole gel has shown high effectiveness, safety and favorable tolerability.

This paper examines the impact of working capital management on the profitability of Dabur Nepal Pvt. Ltd. over a ten-year period from FY 2015/16 to FY 2024/25. The research adopts a descriptive and analytical design, relying exclusively on secondary data extracted from company financial statements and its website. Key working capital components—Inventory Conversion Period (ICP), Receivable Conversion Period (RCP), Payable Deferral Period (PDP), and Cash Conversion Period (CCP)—serve as independent variables, while Return on Assets (ROA) represents the dependent variable. Statistical tools such as correlation and regression analyses were employed to explore the relationships between these variables. The descriptive results revealed that the company’s mean ROA was 7.94%, with moderate variability, and the mean ICP, RCP, PDP, and CCP were 137.85, 73.85, 76.31, and 135.38 days, respectively. Correlation analysis indicated that ROA was positively correlated with ICP but negatively correlated with RCP, PDP, and CCP, suggesting that longer collection and payment cycles may adversely affect profitability. However, regression results showed that the model was not statistically significant (R² = 0.118, p = 0.847), implying that these working capital variables collectively explain only a small portion of ROA variation. The study concludes that while working capital components exhibit some association with profitability, their combined effect on ROA is minimal. It recommends expanding future research to include multiple firms across sectors, larger datasets, and additional financial variables to gain deeper insights into the relationship between working capital efficiency and corporate profitability in Nepal’s manufacturing sector.

In this installment of The Big Picture, Christians provides a history of tariffs in the United States, explaining how both extremes of protectionism and liberalization have affected trade and the economy overall.

World economies have become more globalized and interconnected, with new advanced aspects of employment that are highly automated and technological. This leads to new work requirements that have rapidly been evolving since the beginning of the twenty-first century. Performing in such a competitive environment necessitates qualified job candidates who are not only competent in hard knowledge but also in soft skills. This forces employers to look for graduates with strong interpersonal and problem-solving skills, and a significant ability to manage various tasks and missions. In this context, this paper investigates the status of soft skills, students’ and employers’ attitudes towards them, and the possible merit and / or insignificance attributed to these skills for the student’s current educational and later professional endeavor. 120 Engineering and Science students from Hassan II and Cadi Ayyad Universities and 15 Casablanca and Rabat-based companies participated in the study. The findings reveal that both students and employers give greater importance to soft skills as essential requirements for job finding and employment success.

The Japanese species of the genus Leptobatopsis Ashmead, 1900 are revised. A total of eight species are recorded from Japan, including a new species, Leptobatopsis yaima sp. nov., and three species, L. annularis Kasparyan, 2007, L. koreana Lee & Kang, 2015, and L. nigricapitis Chandra & Gupta, 1977, newly recorded from Japan. A Chinese species L. annularis Sheng & Sun, 2013 is a homonym of L. annularis Kasparyan, 2007. Both species are clearly different, and we therefore propose a new replacement name for the former, L. sinica (nom. nov.). Leptobatopsis daedeokensis Lee & Kang, 2015 is newly synonymised with L. annularis Kasparyan, 2007. The taxonomic position of L. nigra immaculata Momoi, 1971 is changed from a subspecies of L. nigra Cushman, 1933 to separate species, L. immaculata. The female of L. badia Momoi, 1970 is newly described. A key to the Japanese species of this genus is proposed.

Objective: Obesity is a common health problem and a complex disease that is defined as overly fat deposition in adipotic tissue. Studies conducted in our country (Turkey) have reported prevalence of obesity between 12 and 22 percent. Obesity has been shown to be associated with several rheumatic diseases and inflammation. The aim of this study is to assess the prevalence of obesity in rheumatologic diseases, and possible relationships between disease activity and accompanying obesity.

Jabatan akademik dosen adalah sebuah karir dan juga merupakan pengakuan kemampuan seorang dosen dalam menjalankan Tridharma Perguruan Tinggi. Untuk dapat memperolehnya, setiap dosen harus menjalani serangkaian penilaian kredit poin (Penilaian Angka Kredit-PAK) sesuai dengan aturan yang telah ditetapkan oleh pemerintah melalui Direktoral Jenderal Pendidikan Tinggi, yang sekarang berada di bawah Kementerian Riset, Teknologi, dan Pendidikan Tinggi. Dosen yang dinilai harus mengisi sejumlah dokumen yang mendata kegiatan tridharma-nya selama setidaknya empat tahun ke belakang. Selain itu, setiap semester mereka juga diharuskan mengisi dokumen serupa dalam bentuk laporan Beban Kerja Dosen (BKD), berbasis Microsoft Access. Di sisi lain, UPN “Veteran” Jawa Timur juga telah mencatat data-data pribadi, pendidikan, dan sejarah akademis semua pegawainya dalam sistem informasi internal SIMPEG (Sistem Informasi Manajemen Pegawai, berbasis Borland Delphi) dan juga SIDOS (Sistem Informasi Dosen, berbasis Microsoft SQL Server) yang juga harus diisi dan rutin diupdate oleh tiap pegawai/dosen. Pada dasarnya data di ketiga sistem informasi tersebut adalah serupa dan dapat digunakan dalam proses PAK untuk menjaga konsistensi dan validitas data. Penelitian ini bertujuan untuk mengumpulkan data dari sistem BKD dan SIMPEG dan mengintegrasikannya untuk membuat model aplikasi berbasis web untuk PAK. Terdapat total 76 data dosen dari 3 semester laporan BKD yang digunakan dalam penelitian ini. Tabel dari SIDOS digunakan sebagai template untuk desain tabel di database yang baru dibuat di sistem ini yang menggunakan framework Ruby on Rails. Sebuah rintisan aplikasi web telah dibuat untuk menampilkan data yang telah dikumpulkan dan dapat dikustomisasi untuk menampilkan informasi yang berkaitan dengan kegiatan tridharma seorang dosen tertentu.

A Deus,