Seven Counties Services

IntroductionPatients with alcohol use disorder (AUD) exhibit symptoms such as alcohol withdrawal, depression, and cravings. The gut-immune response may play a significant role in manifesting these specific symptoms associated with AUD. This study examined the role of gut dysfunction, proinflammatory cytokines, and hormones in characterizing AUD symptoms.MethodsForty-eight AUD patients [men (n = 34) and women (n = 14)] aged 23–63 years were grouped using the Clinical Institute Withdrawal Assessment of Alcohol Scale (CIWA) as clinically significant (CS-CIWA [score > 10] [n = 22]) and a clinically not-significant group (NCS-CIWA [score ≤ 10] [n = 26]). Clinical data (CIWA, 90-day timeline followback [TLFB90], and lifetime drinking history [LTDH]) and blood samples (for testing proinflammatory cytokines, hormones, and markers of intestinal permeability) were analyzed. A subset of 16 AUD patients was assessed upon admission for their craving tendencies related to drug-seeking behavior using the Penn-Alcohol Craving Score (PACS).ResultsCS-CIWA group patients exhibited unique and significantly higher levels of adiponectin and interleukin (IL)-6 compared to NCS-CIWA. In the CS group, there were significant and high effects of association for the withdrawal score with gut-immune markers (lipopolysaccharide [LPS], adiponectin, IL-6, and IL-8) and for withdrawal-associated depression with gut-immune markers (scored using MADRS with LPS, soluble cells of differentiation type 14 [sCD14], IL-6, and IL-8). Craving (assessed by PACS, the Penn-Alcohol Craving Scale) was significantly characterized by what could be described as gut dysregulation (LBP [lipopolysaccharide binding protein] and leptin) and candidate proinflammatory (IL-1β and TNF-α) markers. Such a pathway model describes the heavy drinking phenotype, HDD90 (heavy drinking days past 90 days), with even higher effects (R2 = 0.955, p = 0.006) in the AUD patients, who had higher ratings for cravings (PACS > 5).DiscussionThe interaction of gut dysfunction cytokines involved in both inflammation and mediating activity constitutes a novel pathophysiological gut–brain axis for withdrawal symptoms and withdrawal-associated depression and craving symptoms in AUD. AUD patients with reported cravings show a significant characterization of the gut–brain axis response to heavy drinking.Trial registrationClinicalTrials.gov, identifier: NCT# 00106106.

Distribution of urban tree canopies is generally not uniform. Multiple variables have been shown to be associated with tree canopy cover, including violence, health, and general well-being. Herein we examine the relationship of tree cover with intentional deaths. Suicide, homicide, and tree cover data were examined by ZIP code for Louisville, a mid-sized city in Kentucky. Relationship between intentional death (suicide and homicide) and tree cover was examined with Poisson regression analysis. In both univariate and multivariate models, suicides (P < 0.0001 and P = 0.0005), homicides (P < 0.0001 and P = 0.03), and combination (P = 0.0541) were negatively associated with tree cover. In this exploratory study we have found that sparse canopy cover is associated with higher rates of intentional human death (both suicides and homicides). Given that suicides and homicides are relatively rare occurrences, these data suggest that larger samples be examined to confirm the relationship between intentional death and canopy cover.

The present study examined the potentially mediating effect of alcohol expectancies and moderating effect of acculturation on the relationship between peer alcohol use and Latino adolescent alcohol use. Participants were 115 adolescents recruited through alternative schools, community events, a community psychologist, and Latino groups at a midwestern university. Questionnaires in this study assessed adolescents' perceptions about both their own and their peers' alcohol use in addition to their expectancies about the effects of alcohol, and their level of acculturation. Demographic characteristics of the sample were also assessed in order to control for their possible effects (e.g., age, gender). Results from the present study indicated that a higher level of peer alcohol use was associated with a higher level of adolescent alcohol use. Additionally, adolescents' expectancies about the effect of alcohol on their social behavior mediated the relationship between peer alcohol use and adolescent alcohol use. Results support previous research suggesting the importance of peers as role models for Latino adolescent alcohol use. Acculturation did not moderate the relationship between peer and adolescent alcohol use. The present study adds understanding as to how Latino adolescents' beliefs regarding alcohol use may influence the relationship between peer alcohol use and adolescent alcohol use.

Both the reliability and validity of the Family Resource Scale (FRS) are described. The FRS is a 30-item rating scale for measuring the adequacy of resources in households with young children. The ordinality of the items, rank ordered from the most to least basic, was established in a study of 28 professionals. Both the reliability and validity of the scale was established in a second study of 45 mothers of preschool-aged children. The utility of the FRS for assessment and intervention purposes is discussed.