Sienna Technologies (United States)

Initial characterization of MEMS-based single crystal 4H-SiC piezoresistive pressure sensors has been performed to determine the operational reliability over time at 800 °C. Important parameters such as the zero pressure offset, bridge resistance, and pressure sensitivity as affected by temperature were extracted. These parameters showed relative stability within the prescribed operational window of the sensor at 800 °C. Of significance was the increase in pressure sensitivity with increasing temperature beyond 400 °C, to the extent that the sensitivity at 800 °C equal to or higher than the room temperature value. The sensor can, therefore, be inserted further into the higher temperature section of the test article, thereby making it possible to capture higher frequency bandwidths of the thermoacoustic instabilities, which is critical for the validation of computational fluid dynamics predictive models.

Skin Research and TechnologyVolume 25, Issue 6 p. 903-905 LETTER TO THE EDITOR Multispectral three-dimensional imaging for chronic wound modelization: Proof of concept Vincent Bérot, Vincent Bérot orcid.org/0000-0002-9582-4648 Dermatology Unit, Saint-Etienne University Hospital, Saint-Etienne, FranceSearch for more papers by this authorJordane Malleret, Jordane Malleret TRIDIMEO, Orsay, FranceSearch for more papers by this authorRémi Michel, Rémi Michel TRIDIMEO, Orsay, France Lab. of Remote Sensing, CEA, Bruyères-le-Chatel, FranceSearch for more papers by this authorLinda Tognetti, Linda Tognetti Dermatology Unit, Medical, Surgical and Neurologic Sciences Departement, Sienna University, Sienna, Italy Medical Biotechnologies Departement, Sienna University, Sienna, ItalySearch for more papers by this authorPietro Rubegni, Pietro Rubegni Dermatology Unit, Medical, Surgical and Neurologic Sciences Departement, Sienna University, Sienna, ItalySearch for more papers by this authorElisa Cinotti, Elisa Cinotti orcid.org/0000-0002-4009-0659 Dermatology Unit, Medical, Surgical and Neurologic Sciences Departement, Sienna University, Sienna, ItalySearch for more papers by this authorJean-Luc Perrot, Corresponding Author Jean-Luc Perrot [email protected] Dermatology Unit, Saint-Etienne University Hospital, Saint-Etienne, France Faculty of Medicine, Jean-Monnet University, Saint-Etienne, France Correspondence Jean-Luc Perrot, Dermatology Unit, Saint-Etienne University Hospital, Avenue Albert Raimond, 42270 Saint-Priest-en-Jarez, France. Email: [email protected]Search for more papers by this author Vincent Bérot, Vincent Bérot orcid.org/0000-0002-9582-4648 Dermatology Unit, Saint-Etienne University Hospital, Saint-Etienne, FranceSearch for more papers by this authorJordane Malleret, Jordane Malleret TRIDIMEO, Orsay, FranceSearch for more papers by this authorRémi Michel, Rémi Michel TRIDIMEO, Orsay, France Lab. of Remote Sensing, CEA, Bruyères-le-Chatel, FranceSearch for more papers by this authorLinda Tognetti, Linda Tognetti Dermatology Unit, Medical, Surgical and Neurologic Sciences Departement, Sienna University, Sienna, Italy Medical Biotechnologies Departement, Sienna University, Sienna, ItalySearch for more papers by this authorPietro Rubegni, Pietro Rubegni Dermatology Unit, Medical, Surgical and Neurologic Sciences Departement, Sienna University, Sienna, ItalySearch for more papers by this authorElisa Cinotti, Elisa Cinotti orcid.org/0000-0002-4009-0659 Dermatology Unit, Medical, Surgical and Neurologic Sciences Departement, Sienna University, Sienna, ItalySearch for more papers by this authorJean-Luc Perrot, Corresponding Author Jean-Luc Perrot [email protected] Dermatology Unit, Saint-Etienne University Hospital, Saint-Etienne, France Faculty of Medicine, Jean-Monnet University, Saint-Etienne, France Correspondence Jean-Luc Perrot, Dermatology Unit, Saint-Etienne University Hospital, Avenue Albert Raimond, 42270 Saint-Priest-en-Jarez, France. Email: [email protected]Search for more papers by this author First published: 20 May 2019 https://doi.org/10.1111/srt.12720Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume25, Issue6November 2019Pages 903-905 RelatedInformation

Abstract IA chemotherapy is a promising primary and salvage treatment for moderate and advanced RB particularly in eyes designed for enucleation. Indications include: Primary treatment of unilateral retinoblastoma Reese‐Ellsworth Stage II, III, IV, Va & Vb (ABC Stage B, C & D) ;adjunctive treatment after systemic chemotherapy, with or without focal therapy ;incomplete response to conservative therapy; local tumor recurrence after conservative therapy. Most of adverse side effects are transient, choroidal vasculopathy is permament and in some cases progressive. Intra‐arterial chemotherapy conserves many eyes with retinoblastoma that would otherwise require enucleation, at the same time avoiding the risks of radiotherapy and systemic chemotherapy.

We have undertaken an extensive study to determine and to control the factors to reduce the loss tangent of AlN to match those of Al2 O3 and BeO (tan5 equiv 0.0005) without adversely affecting its thermal conductivity, dielectric strength, and mechanical strength

This paper presents theoretical modeling and experimental results of light scattering studies on latex (polystyrene) particle dimers and colloidal gold particles coupled to individual latex particles. The latex particle size range is 1 - 10 micrometer (in diameter) and that of the gold particles is 80 - 100 nm. In general, the latex particles are spherical, while the colloidal gold particles have varied shapes. The theoretical model is based on exact solution of the problem of light scattering by interacting spheres. Calculations based on interacting and noninteracting particles will be compared to experimental results. The experimental results were obtained with high resolution light scattering measurements of particle coupling in a flow particle analyzer. This analyzer, Copalis<SUP>TM</SUP> (Coupled Particle Light Scattering), exploits particle coupling induced by antigen-antibody, receptor- hormone, or nucleic acid interactions in medical diagnostic assays. Although latex particle coupling produces a range of aggregate sips, only dimer light scattering results are relevant. Coupling of gold to latex particles in the Copalis<SUP>TM</SUP> diagnostic system produces from one to many gold particles per latex particle. Coherent addition of fields scattered by many gold-latex pairs has been used to simulate the gold-based assay. The comparison of theoretical simulations and experimental results for the coupling will be discussed. The results of this study are being used to refine the particle coupling results in the Copalis<SUP>TM</SUP> diagnostic system.

PT-9K/129G, a nontoxic mutant of pertussis toxin (PT) obtained by genetic manipulation, has been shown in animal models to be a promising candidate for new vaccines against whooping cough. To assess the safety and the immunogenicity of PT-9K/129G in humans, a pilot study has been performed in adult volunteers. The protein was found to be safe, capable of inducing high titers of toxin-neutralizing antibodies, and capable of generating immunological memory. In fact, vaccination caused an increase of cell-mediated response to PT, PT-9K/129G, S1 subunit, and B oligomer, indicating that memory T cells are induced by the vaccine. Since PT-9K/129G is mitogenic for T lymphocytes in vitro, it was investigated whether this activity is also present in vivo. No variation was observed in the proportion of T cells (CD3+), T helper cells (CD4+), and cytotoxic T cells (CD8+), as well as in that of other lymphoid populations, by FACS analysis. Interestingly, no thorough correlation was found between humoral and cellular responses. In one case, a very high cellular response was present in absence of detectable antibodies, suggesting that the antibody response, which is the only parameter measured in most clinical trials, may not give a complete picture of the response induced by a vaccine.