Sofradir (France)

Abstract Objective Hereditary angioedema (HAE) is a rare disease that presents with recurrent attacks that can be triggered by stress or other emotions. The emotional impact of HAE is well-documented, although mainly via self-reported questionnaires. In this study, we used physiological measures to investigate stress regulation in patients with HAE and compared them to patients with immune thrombocytopenia (ITP), a disease that also progresses with attacks but without emotional triggers. Methods Twenty-six adult patients with HAE or ITP (13 each) were included in the study. Patients were asked to perform several computerized tasks that activated different branches of the autonomic nervous system (ANS). Heart rate variability and electrodermal activity were measured during the experimental tasks and a medical consultation that followed the experiments. Results Patients with HAE did not differ from patients with ITP in their physiological responses. In the reactivity tasks, a non-significant correlation significance was observed between reaction times (RTs) and peak spread in the HAE and ITP groups only for male patients and in a different way for HAE (negative correlation) and ITP (positive correlation). During medical consultations, an association between the physician’s perception of the patient’s stress and the patient’s physiological measures of stress was found only in female HAE patients, but without significance. Conclusions The ANS of patients with HAE and ITP was similarly and abnormally activated, with a possible effect by sex. These results shed new light on the role of emotional regulation in chronic diseases. Trial registration This article does not report the results of a health care intervention on human participants. The research was not preregistered in any registry. The analysis plan was not preregistered in an independent, institutional registry. Data, analytic methods, and study materials are not made directly available.

The medical device industry is undergoing substantial transformations, looking to face the increasing pressures on healthcare systems and fundamental shifts in healthcare delivery. There is an ever-growing emphasis on identifying underserved clinical requirements and enhancing industry-academia partnerships to accelerate innovative solutions. In this context, an analysis of the requirements for translation, highlighting support and funding for innovation to transform an idea for a biomaterial device into a commercially available product, is discussed.

Objetivo: Conhecer os impactos da Lúpus na saúde mental de mulheres. Método: Revisão bibliográfica de caráter integrativo com a seleção de 15 artigos científicos devidamente publicados entre os anos de 2018 e 2023, nos bancos de dados, PubMed, Medline, Banco de Dados de Enfermagem – BDENF, Lilacs e National Library of Medicine. Resultados e Discussão: Dentre os estudos selecionados foi identificado que a saúde mental da mulher vitimada de Lúpus Eritematoso Sistêmico é diretamente afetada em razão de vários fatores, como a dificuldade do diagnóstico, o sofrimento causado pelas dores da doença, os impactos e impedimentos físicos das sequelas, as consequências dermatológicas, entre outros. Tais condições são causadoras de impactos da saúde mental com questões que envolvem desde o isolamento social, as dificuldades em estabelecer relações, os sentimentos de insegurança quanto as perspectivas de futuro, com a possibilidade de desenvolvimento de agravos maiores, como ansiedade e depressão, ocasionando em casos mais graves ocorrências de suicídio. Considerações Finais: A realização da presente pesquisa se mostrou necessária para o desenvolvimento de habilidades das pesquisadoras junto a mulheres que sejam diagnosticadas com Lúpus, com a identificação das intercorrências da saúde mental destas pacientes, bem como o apontamento da necessidade de intervenções junto às mesmas.

A novel synthetic fully long-term resorbable self-gripping mesh has been recently developed to reinforce soft tissue where weakness exists during ventral hernia repair open procedures. This resorbable mesh is a macroporous, knitted, poly-L-lactide, poly-trimethylene carbonate copolymer monofilament mesh with the ProGrip™ technology, providing grips on one side of the mesh. A new poly-L-lactide, poly-trimethylene copolymer was developed to provide the required features for mechanical support during at least 20 weeks covering the critical healing period, including resistance to fatigue under cyclic loading conditions, as it occurs in patients. The yarns and mesh initial physical and biomechanical properties were characterized. Then, the mesh mechanical strength was evaluated over time. The mechanical properties of the proposed mesh were found to be above the generally recognized threshold value to mechanically support the repair site of a hernia over a 20-week period during in-vitro cyclic loading test. The mesh performance was evaluated in vivo using a published preclinical porcine model of hernia repair at 4-, 12- and 20-weeks post implantation. The burst strength of the hernia repair sites reinforced with the new mesh were higher at 4 & 12 weeks and comparable at 20 weeks to the one of the native abdominal walls. At all time points, the mesh was well tolerated with moderate inflammation and was fast integrated in the abdominal wall at 4 weeks. Particularly, the grips were nicely engulfed in the newly formed connective tissue. They must facilitate the anchoring of the mesh by their extension from the mesh and their mushroom shape. The preclinical data of the self-gripping resorbable mesh suggests that it has all the favorable characteristics for future clinical use during ventral hernia repair open procedures.Graphical

Économie de guerre, économie dirigée, une approche économique différente de l’économie globalisée libérale et mondialisée que nous connaissons. Passer à une économie de guerre nécessite de profondes et rapides mutations sous le contrôle étroit de l’État, afin de répondre à des besoins opérationnels conséquents.

Abstract Medtronic recently developed a novel synthetic fully long-term resorbable self-gripping mesh to reinforce soft tissue where weakness exists during ventral hernia repair procedures. This resorbable mesh is a macroporous, knitted, poly-L-lactide, poly-trimethylene carbonate copolymer monofilament mesh with the ProGrip™ technology. The biocompatibility profile of the mesh has been extensively established and documented. No systemic nor local adverse reactions have been observed from implantation to complete resorption and metabolization of the mesh in a subcutaneous implantation preclinical rabbit model. Its performance was evaluated at 20 weeks using a modified published preclinical porcine model of hernia repair (Martin, 2013; Deeken, 2013). Histologic examination of the implantation sites confirmed that this novel mesh was well tolerated and led to new extracellular collagen matrix formation. The burst strength of the hernia repair sites reinforced with the new mesh was statistically equivalent to the one of the native abdominal walls. Currently marketed ProGrip™ meshes have been clinically and successfully used with less mechanical fixation devices than non-self-gripping meshes (Chastan, 2009; Rangwani, 2021). The new self-gripping long-term resorbable mesh fixation performance was demonstrated to be statistically equivalent to the one of ProGrip™ Self-Gripping Polyester Mesh both in ex-vivo testing and in an in vivo porcine model. This should support the ease-of-use feature of the mesh with a limited need for additional mechanical fixation, which will likely be associated with a shorter surgical time. The preclinical tests of the self-gripping resorbable mesh are compelling enough to make it a new mesh candidate for future clinical use.

Bu çalışmanın temel amacı Şanlıurfa'daki geleneksel sıra gecesi aktivitelerinin turizmle ilişkisinin araştırılmasıdır.Çalışmada yarı yapılandırılmış bir soru formu ile görüşme tekniği kullanılmış ve Şanlıurfa'da sıra gecesi düzenleyen 19 işletme

\n Contains fulltext :\n 237868.pdf (Publisher’s version ) (Open Access)\n

The expression "State", due to the uncertainties and objections presented by several scholars in the area, is difficult to determine, since it has several conceptual variations and behavioral positions. For this reason, this article seeks, from the identification of this problem, to discuss the notion of citizenship in Brazil, highlighting the way of effectiveness by the citizens of the jeitinho brasileiro. In fact, it is expected to contribute to the modern discussions about the role and constitution of the Brazilian state, considering variables such as corruption and social positioning.