Spectronic (Sweden)

PurposeA hybrid magnetic resonance linear accelerator (MRL) can perform magnetic resonance imaging (MRI) with high soft‐tissue contrast to be used for online adaptive radiotherapy (oART). To obtain electron densities needed for the oART dose calculation, a computed tomography (CT) is often deformably registered to MRI. Our aim was to evaluate an MRI‐only based synthetic CT (sCT) generation as an alternative to the deformed CT (dCT)‐based oART in the abdominal region.MethodsThe study data consisted of 57 patients who were treated on a 0.35 T MRL system mainly for abdominal tumors. Simulation MRI‐CT pairs of 43 patients were used for training and validation of a prototype convolutional neural network sCT‐generation algorithm, based on HighRes3DNet, for the abdominal region. For remaining test patients, sCT images were produced from simulation MRIs and daily MRIs. The dCT‐based plans were re‐calculated on sCT with identical calculation parameters. The sCT and dCT were compared in terms of geometric agreement and calculated dose.ResultsThe mean and one standard deviation of the geometric agreement metrics over dCT–sCT‐pairs were: mean error of 8 ± 10 HU, mean absolute error of 49 ± 10 HU, and Dice similarity coefficient of 55 ± 12%, 60 ± 5%, and 82 ± 15% for bone, fat, and lung tissues, respectively. The dose differences between the sCT and dCT‐based dose for planning target volumes were 0.5 ± 0.9%, 0.6 ± 0.8%, and 0.5 ± 0.8% at D2%, D50%, and D98% in physical dose and 0.8 ± 1.4%, 0.8 ± 1.2%, and 0.6 ± 1.1% in biologically effective dose (BED). For organs‐at‐risk, the dose differences of all evaluated dose–volume histogram points were within [–4.5%, 7.8%] and [–1.1 Gy, 3.5 Gy] in both physical dose and BED.ConclusionsThe geometric agreement metrics were within typically reported values and most average relative dose differences were within 1%. Thus, an MRI‐only sCT‐based approach is a promising alternative to the current clinical practice of the abdominal oART on MRL.

We report 10,000-hour stable operation of a 266-nm picosecond laser with an average power of 20 W. We have developed a narrow-linewidth, high-peak-power 1064-nm laser source with a repetition rate of 600 kHz, an average power of 129 W, a linewidth of 0.15 nm, and a pulse duration of 14 ps using a gain-switched DFB-LD as a picosecond pulse seed source and a four-stage power amplifier with an Nd:YVO4 crystal. A 266-nm laser with a maximum average power of 25.4 W was generated by frequency conversion using LBO and CLBO crystals and had a pulse duration of 8 ps and beam quality factor of 1.5 at 20W. To the best of our knowledge, we also demonstrated that the average power and the beam quality can be maintained for 10,000 hours for the first time. We have confirmed the durability of the developed deep ultraviolet laser for industrial applications.