Splošna Bolnišnica Celje

Rheumatoid arthritis (RA) is a chronic systemic autoimmune connective tissue disorder that leads to disability, impairment and premature mortality. As non-pharmacological approaches that do not interfere with existing treatments, magnetotherapy, laser therapy, electrotherapy and cryotherapy present promising supplemental options. Although they are employed in the treatment of RA patients,their mechanisms of action and advantages are not fully understood and remain an area of ongoing research. Aim of the Study: This review explores the mechanisms of magnetotherapy, laser therapy, electrotherapy andcryotherapy and evaluates their effects on inflammation, oxidative stress, pain, and functional outcomes in RA, providing insights into their potential as a complementary treatment and identifying potential risks. Materials and Methods: A review of research literature was conducted through databases such as PubMed, Google Scholar, ResearchGate, and the Cochrane Library Results: The studied methods effectively reduced pain and disease activity in RA patients. Conclusions: These methods can complement conventional treatments, but further research is needed to standardize protocols and assess risks.

Rheumatoid arthritis (RA) is a chronic inflammatory disease that significantly impacts patients' mobility and quality of life. While pharmacotherapy remains the primary approach to symptom management, increasing attention is being given to non-pharmacological treatment methods. This literature review explores alternative therapeutic interventions for RA, including anti-inflammatory diets, physical exercise, education, curcumin supplementation, psychotherapy, stem cell therapy, cannabinoids, cryotherapy, yoga, meditation, and mindfulness. These methods target different aspects of RA pathology, such as inflammation modulation, pain reduction, and psychological well-being. Studies suggest that dietary modifications, particularly the Mediterranean diet, may help reduce inflammation and improve joint function. Regular physical activity has demonstrated benefits in maintaining joint mobility and reducing pain perception. Psychological interventions, including cognitive-behavioral therapy, enhance patients' coping mechanisms, reducing stress-related inflammation and depressive symptoms. Additionally, emerging treatments like stem cell therapy and cannabinoids offer promising but still experimental alternatives. While these interventions cannot replace pharmacotherapy, they can serve as valuable adjuncts, potentially improving clinical outcomes and reducing reliance on long-term medication. Further research is needed to establish standardized guidelines for integrating these approaches into RA management strategies. This review highlights the necessity of a comprehensive, multidisciplinary approach to RA treatment that includes both conventional and alternative therapies.

La estructura informativa y la argumentación son dos fenómenos tan estrechamente relacionados que los recursos de estructuración informativa tienen trascendencia argumentativa y los mecanismos argumentativos conllevan relieve informativo (Fuentes Rodríguez/Alcaide Lara 2002, 224). Por eso, en el presente estudio pretendemos indagar en una de las facetas de esta relación e investigar el potencial argumentativo que muestran algunos procedimientos sintácticos de tematización y de focalización. Para ello caracterizamos brevemente las nociones clave de la estructura informativa y de la argumentación lingüística y estudiamos cómo se relacionan en el discurso. Centrándonos en el discurso periodístico como aquel que está inherentemente orientado a informar, y también a persuadir, delineamos la relevancia que ambos fenómenos presentan en la prensa. Con el propósito de acercarnos a un panorama general del potencial argumentativo que se vislumbra en la tematización y la focalización, examinamos finalmente un corpus de elaboración propia y analizamos los fines argumentativos con que se aprovechan ambos mecanismos.

O Diabetes Mellitus Gestacional (DMG) é uma condição metabólica que se manifesta durante a gestação, caracterizadapela hiperglicemia. Sua prevalência é influenciada por fatores de risco como obesidade, histórico familiar de diabetes,idade avançada da mãe e etnia. O diagnóstico precoce é crucial, sendo o teste de tolerância à glicose oral o métodopadrão. A DMG implica em uma série de complicações para a mãe e o feto, incluindo macrossomia, pré-eclâmpsia erisco aumentado de diabetes tipo 2 no futuro. Os mecanismos fisiopatológicos da DMG envolvem resistência à insulinae disfunção das células beta pancreáticas, exacerbadas por mudanças hormonais durante a gravidez. Essas alteraçõesresultam em uma menor capacidade das células em responder à insulina, elevando os níveis de glicose no sangue. Omanejo da DMG requer uma abordagem multidisciplinar que inclui modificações no estilo de vida, monitoramentorigoroso da glicemia e, em alguns casos, terapia medicamentosa. A intervenção precoce e contínua visa mitigar osriscos associados, promovendo resultados positivos tanto para a mãe quanto para o bebê. Em resumo, a DMGrepresenta um desafio significativo para a saúde materna e fetal. No entanto, com um entendimento aprofundado dosfatores de risco, mecanismos fisiopatológicos, métodos diagnósticos e estratégias terapêuticas, é possível oferecer umcuidado abrangente e eficaz, garantindo melhores desfechos para as gestantes afetadas.

As a breakthrough in increasing the number of customers as a marketing strategy, the management of Jiwa Toast Citraland Surabaya is trying to maintain and increase brand preferences, quality perceptions and customer value perceptions of the product. Brand preference is considered effective in influencing consumers about a product/service because it tends to contain an honest experience or person's choice of a particular product/service in addition to maintaining product quality and customer value perceptions. This research aims to find out and analyze how much influence Brand Preference, Perceived Quality and Perceived Value have on the Purchasing Decisions of Jiwa Toast Citraland Surabaya customers. The method used in this research is a quantitative method with multiple linear regression analysis techniques. The results of this researchconclude that there is a positive and significant influence, both partially and simultaneously, from Brand Preference, Perceived Quality and Perceived Value on the Purchasing Decisions of Jiwa Toast Citraland Surabaya customers.

This research examines the dynamics of commercial real estate prices in the Brazilian market, exploring the potential presence of speculative movements within the real estate market for the period 2012-2023. The study utilizes a conventional present value asset pricing model with a consistent discount factor and employs established bubble tests from the finance literature. These tests encompass assessments for explosive bubbles, periodic bubbles, multiple explosive bubbles and intrinsic bubbles. As a result, this approach allows us to diagnose unsustainable trends in the trajectory of real estate asset prices, should speculative bubbles be detected within the series. Utilizing data from the Fipezap survey provided by the Institute of Economic Research Foundation (FIPE), the study identifies evidence of periods marked by price exuberance, as indicated by the explosive bubble test and the multiple bubble test for some cities and the national price index. However, using the corresponding tests, no evidence of periodically collapsing bubbles and intrinsic bubbles was found across any of the considered cities.

Mukopolisaharidoze so skupina lizosomskih bolezni kopičenja. Njihova skupna značilnost je pomanjkanje delovanja encimov, ki razgrajujejo glikozaminoglikane, polisaharide, ki se povezujejo s proteoglikani in tvorijo zunajcelični matriks. Ker ni encimov, ki bi glikozaminoglikane razgrajevali, se ti kopičijo v lizosomih in povzročijo njihovo okvaro in zato se okvarijo drugi celični organeli, celice in končno organi. Klinična slika je široka, od nevro-kognitivnega upada, skeletno-mišičnih deformacij in tipičnih obraznih sprememb. Ključno je zgodnje prepoznavanje bolezni, čeprav s trenutno dostopnimi načini zdravljenja bolezni ne moremo ozdraviti, lahko pa le upočasnimo njen potek, kar je najbolj učinkovito v fazi bolezni še pred pojavom simptomov. Obetavni način zdravljenja je gensko zdravljenje, ki nakazuje možnost ozdravitve bolezni.Predstavljamo primer dečka, pri katerem je bil prepoznan zgodnji kognitivni upad in za bolezen tipične spremembe. Napoten je bil v terciarno ustanovo, kjer je bila diagnoza potrjena. Deček je bil julija 2018 zdravljen z eksperimentalnim genskim zdravljenjem v tujini (bolnišnica San Raffaele, Milano, Italija). V opisanem primeru gre po našem vedenju za prvo uspešno izpeljano gensko zdravljenje pri slovenskih bolnikih ter za enega prvih primerov genskega zdravljenja mukopolisaharidoze tipa I v svetovnem merilu. Gensko zdravljenje s tem postaja del nove klinične stvarnosti, kar predstavlja pomemben mejnik za naš prostor. Zaradi naprednih zdravljenj bi bilo v prihodnosti smiselno uvesti presejalno testiranje novorojenčkov za MPS tipa I, ki se pri nas ali v Evropi doslej še ne izvaja. Do tedaj pa ostaja najpomembnejši predpogoj za uspešno zdravljenje zgodnja klinična prepoznava bolezni in napotitev v terciarno zdravstveno ustanovo.

Human milk, especially mother's milk, is the optimal food for infants. Breastfed children grow and gain weight more appropriately, are less often ill and have better neurological development. The unique composition of human milk, which contains anti-infective and anti-inflammatory factors, along with skin-to-skin contact from direct breastfeeding, promotes optimal growth, protects from environmental risk factors, and promotes the development of the child's innate immune system. Human milk, compared to infant formula, also provides continued protection against acute illnesses in the first years of life. Breastfeeding has been associated with long-term benefits by reducing the risk of several chronic diseases. Extensive research confirms that many acute and chronic paediatric disorders, such as otitis media, acute diarrhoeal diseases, lower respiratory illnesses, sudden infant death syndrome, inflammatory bowel disease, childhood leukaemia, diabetes mellitus, obesity, hypertension, asthma, and atopic dermatitis, occur less frequently among children who were breastfed at an early age. In this review article, some of the benefits of breastfeeding and feeding with breast milk or human milk for the child are discussed.

Human milk, especially mother's milk, is the optimal food for infants. Breastfed children grow and gain weight more appropriately, are less often ill and have better neurological development. The unique composition of human milk, which contains anti-infective and anti-inflammatory factors, along with skin-to-skin contact from direct breastfeeding, promotes optimal growth, protects from environmental risk factors, and promotes the development of the child's innate immune system. Human milk, compared to infant formula, also provides continued protection against acute illnesses in the first years of life. Breastfeeding has been associated with long-term benefits by reducing the risk of several chronic diseases. Extensive research confirms that many acute and chronic paediatric disorders, such as otitis media, acute diarrhoeal diseases, lower respiratory illnesses, sudden infant death syndrome, inflammatory bowel disease, childhood leukaemia, diabetes mellitus, obesity, hypertension, asthma, and atopic dermatitis, occur less frequently among children who were breastfed at an early age. In this review article, some of the benefits of breastfeeding and feeding with breast milk or human milk for the child are discussed.

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