Synergie Informatique

We report a clinical case of successful dual-site physiological pacing, integrating Left Bundle Branch Area Pacing (LBBAP) and Bachmann Bundle Pacing (BBP). This procedure utilized Medtronic SelectSecure 3830 leads with C315 and C315S5 delivery sheath

Abstract Cancer cell plasticity plays a key role in tumor progression and treatment resistance in melanoma. While the transcriptional programs enabling adaptative switching between melanocytic and mesenchymal phenotypes are well characterized, unravelling druggable epigenetic regulators that sustain melanoma cell adaptation and resistance remains crucial. Herein, we identified TRIM24, a bromodomain protein frequently upregulated during melanoma metastatic progression, as a crucial regulator of melanoma cell plasticity towards invasive/resistant states. shRNA-mediated knock-down of TRIM24 or degradation using a TRIM24-specific PROTAC decrease the migratory capacities and increase the sensitivity to BRAF inhibitors of melanoma cells. Integration of transcriptomic (RNA-seq) and epigenomic (ATAC-seq, CUT&Tag) analyses reveals that TRIM24 reprograms the epigenome of melanoma cells, promoting mesenchymal and repressing melanocytic transcriptional programs. We further define a TRIM24-specific transcriptional signature, that is consistently enriched in treatment-resistant mesenchymal subpopulations in melanoma single-cell RNA-seq datasets. Accordingly, analysis of TRIM24 protein expression in melanoma patients highlights that high TRIM24 expression correlates with relapse to adjuvant immunotherapy. Finally, TRIM24 knock-down in immunocompetent mouse models synergises with immune checkpoint inhibitors. Overall, our findings spotlight TRIM24 as a major epigenetic regulator driving melanoma cell dedifferentiation and resistance to therapy, representing a promising druggable target to reverse phenotype switching and resensitize to treatment.

In this paper, we introduce correlation technologies both at RF/mmWave and Base-Band frequencies. At RF and mmWave frequencies power-spectra and energy-spectra metrics are introduced for measuring the power-density of mobile devices and systems. The use of unified power-spectra and energy-spectra metrics leads to innovative Electromagnetic-Thermal sensing solutions for OTA-Testing. At Base-Band frequencies, DSP-based Convolutional-Accelerators are proposed for fast and accurate measurement of EVM (Error Vector Magnitude) using correlation technologies. New ASIC-embedded Smart-Connectors are developed for bringing correlation-based signal processing close to antenna-in-package (AiP) modules. Porting of the DSP-based Convolutional-Accelerators into advanced FD-SOI-ASIC platforms for co-integration with adaptive RF/mmWave FrontEnd-Modules will enable real-time extraction of auto-correlation and cross-correlation functions of stochastic signals for mobile devices and systems. Perspectives toward optically synchronized interferometric-correlation technologies are drawn for accurate measurements of stochastic EM fields in noisy environments.

Most common preventive eccentric-based exercises, such as Nordic hamstring do not include any hip flexion. So, the elongation stress reached is lower than during the late swing phase of sprinting. The aim of this study was to assess the evolution of hamstring architectural (fascicle length and pennation angle) and functional (concentric and eccentric optimum angles and concentric and eccentric peak torques) parameters following a 3-week eccentric resistance program performed at long (LML) vs. short muscle length (SML). Both groups performed eight sessions of 3–5 × 8 slow maximal eccentric knee extensions on an isokinetic dynamometer: the SML group at 0° and the LML group at 80° of hip flexion. Architectural parameters were measured using ultrasound imaging and functional parameters using the isokinetic dynamometer. The fascicle length increased by 4.9% (p < 0.01, medium effect size) in the SML and by 9.3% (p < 0.001, large effect size) in the LML group. The pennation angle did not change (p = 0.83) in the SML and tended to decrease by 0.7° (p = 0.09, small effect size) in the LML group. The concentric optimum angle tended to decrease by 8.8° (p = 0.09, medium effect size) in the SML and by 17.3° (p < 0.01, large effect size) in the LML group. The eccentric optimum angle did not change (p = 0.19, small effect size) in the SML and tended to decrease by 10.7° (p = 0.06, medium effect size) in the LML group. The concentric peak torque did not change in the SML (p = 0.37) and the LML (p = 0.23) groups, whereas eccentric peak torque increased by 12.9% (p < 0.01, small effect size) and 17.9% (p < 0.001, small effect size) in the SML and the LML group, respectively. No group-by-time interaction was found for any parameters. A correlation was found between the training-induced change in fascicle length and the change in concentric optimum angle (r = −0.57, p < 0.01). These results suggest that performing eccentric exercises lead to several architectural and functional adaptations. However, further investigations are required to confirm the hypothesis that performing eccentric exercises at LML may lead to greater adaptations than a similar training performed at SML.

Within the office environment there is a trend towards multi-vendor systems with computing power distributed throughout. By its nature, the information and input/output resources are distributed on different nodes and accessed by many users from a variety of terminals. It is this complex scenario which motivated the project to investigate how such systems can be constructed and managed in a consistent manner. The project was convinced that major benefits could be realised if a consistent platform could be provided to application system irrespective of whether the underlying resources were single system/single vendor or distributed over multi-vendor systems. Our approach was to define an architecture (Communication Systems Architecture) that incorporated a number of strategic interfaces, observing standards where appropriate. An object oriented philosophy was adopted. From this architecture, the project constructed a number of platforms (Local CSA Machines) based on single end systems and moved on to implement a prototype platform based on a number of computing nodes linked by both local and wide-area networks (CSA Domain Machine). This paper outlines the architecture, describes the implementation of a Local CSA System, the design of the CSA Domain Machine and concludes by considering the relevance of the architecture to other environments and in which areas standards may be influenced.