Tate & Lyle (United Kingdom)

Type-2 diabetes mellitus (T2DM) is associated with a reduction of butyrate-producing gut bacteria. d-allulose and erythritol are low-no-calorie sweeteners (LNCS) used as sugar substitutes to reduce high free sugar intakes associated with non-communicable diseases, including T2DM. This is the first study to investigate the impact of representative and physiologically relevant doses of d-allulose and erythritol on the human gut microbiota of T2DM ( n = 6) and co-living healthy adults ( n = 6). Using the clinically predictive ex vivo SIFR® technology, d-allulose and erythritol were shown to significantly increase butyrate production 24-48h after treatment and significantly increased the abundance of particular microbial families or species in both healthy individuals and those with T2DM compared to the no-substrate control (NSC). d-Allulose significantly increased the abundance of Anaerostipes hadrus and Lachnospiraceae_unclassified_species ( u _ s) at 48h in healthy adults and adults with T2DM compared to the NSC. Erythritol significantly increased the abundance of Eubacteriaceae and Barnesiellaceae families at 48h in healthy adults and adults with T2DM but had no significant effects on microbial species compared to the NSC. d-Allulose resulted in a larger increase in butyrate between 6-24h whereas erythritol resulted in a larger increased butyrate between 24-48h. The findings suggest prebiotic potential of d-allulose and erythritol worth of investigation in human clinical trials, as blending d-allulose and erythritol could be a promising strategy to reduce free sugar intakes and increase butyrate production in both healthy and T2DM individuals, resulting in beneficial effects on glycemic control.

Low-no-calorie sweeteners (LNCS) are used as sugar substitutes as part of strategies to reduce the risk of chronic diseases related to high sugar intake (e.g. type 2 diabetes (T2D)). This study investigated how a range of sweeteners [tagatose (TA)/maltitol (MA)/sorbitol (SO)/stevia (ST)/sucralose (SU)/acesulfame K (ACK)] impact the gut microbiota of T2D subjects and healthy human adults using the ex vivo SIFR® technology (n = 12). The cohort covered clinically relevant interpersonal and T2D-related differences. ACK/SU remained intact while not impacting microbial composition and metabolite production. In contrast, TA/SO and ST/MA were respectively readily and gradually fermented. ST and particularly TA/SO/MA increased bacterial density and SCFA production product-specifically: SO increased acetate (∼Bifidobacterium adolescentis), whilst MA/ST increased propionate (∼Parabacteroides distasonis). TA exerted low specificity as it increased butyrate for healthy subjects, yet propionate for T2D subjects. Overall, LNCS exerted highly compound-specific effects stressing that results obtained for one LNCS cannot be generalised to other LNCS.

The Natural Resources Conservation Service (NRCS, formerly the Soil Conservation Service, SCS) unit hydrograph (UH) is one of the most commonly used synthetic UH methods for hydrologic modeling and engineering design all over the world. However, previous studies have shown that the application of the NRCS UH method for some ungauged watersheds in the state of Indiana produced unrealistic flood predictions for both the peak discharge and the time to peak. The objective of this work is to customize the NRCS UH by analyzing the role of its two key parameters, namely, the peak rate factor (PRF) and the lag time, in creating the runoff hydrograph. Based on 120 rainfall-runoff events collected from 30 small watersheds in Indiana over the past two decades, the observed UHs are derived and the corresponding PRF and lag time are extracted. The observed UHs in Indiana show that the mean value of PRF is 371, which is lower than the standard PRF of 484, and the NRCS lag time equation tends to underestimate the “true” lag time. Moreover, a multiple linear regression method, especially the stepwise selection technique, is employed to relate the NRCS UH parameters to the most appropriate geomorphic attributes extracted from the study watersheds. Both the statewide and regional regression models show that the main channel slope is a major factor in determining the PRF and lag time. A customized Indiana unit hydrograph, referred as Finley UH to honor David Finley who inspired this study, is derived with updated parameters and the Gamma function. Validation results show that the Finley UH provides more reliable and accurate predictions in terms of the peak discharge and the time to peak than the original NRCS UH for the watersheds in Indiana.

Previous Finance Matters columns in Nursing Administrative Quarterly have emphasized the importance of utilizing financial statements to build and promote a successful evidence-based business case. The latest column addressed return on investment substantiation to solidify the business case being presented. Given the current and future state of federal value-based payment models (where health care delivery providers will accept more downside risk for reimbursement), the cost-benefit and cost-effectiveness analyses can be useful measurements. This column defines utilization of cost-benefit analysis and cost-effectiveness analysis when framing the cost, value, and benefit of an innovative health care intervention.

Abstract The importance of large wood (LW) to riverine functions is well established scientifically and increasingly recognized by river managers in many countries. However, public perceptions largely associate LW with elevated danger and/or need for intervention. Such perspectives are amplified amongst recreational river users (defined here as any individuals that recreate by floating on the water surface of a river) who interact more directly with rivers than the general public and commonly view wood in life‐or‐death terms. Given that human life occupies a highest‐order charge for river managers, they are left in a difficult position when safety appears to conflict with environmental services. LW deficits are perpetuated partly because wood removal, often in the name of safety, is far easier than placing wood in rivers. Further, river restoration practitioners are frequently burdened with expectations and liability unparalleled in built environments. A fundamentally different mindset is necessary to achieve desired ecologic outcomes when working with rivers. Based on two decades of experience as boaters, LW practitioners, and emergency responders, we (1) discuss LW hazard and risk from recreational and management viewpoints, (2) discretize objective and measurable physical properties of LW hazards, and (3) propose a decision framework that implicitly addresses risk by considering LW hazards relative to river use and ambient hazards. The approach is structured to increase objectivity in LW hazard mitigation and diminish asymmetric biases that favor LW removal. Our intent is to build understanding and rational flexibility among risk‐averse management, regulatory, and funding entities to facilitate implementation of scientific understanding without undue risk to river users. © 2020 John Wiley & Sons, Ltd.

An amendment to this paper has been published and can be accessed via the original article.

Carbonyl sulfide (COS) and carbon disulfide (CS2) are important atmospheric gases that are formed from organic sulfur precursors present in natural waters when exposed to sunlight. However, it remains unclear how specific water constituents, such as dissolved organic matter (DOM), affect COS and CS2 formation. To better understand the role of DOM, irradiation experiments were conducted in O2-free synthetic waters containing four different DOM isolates, acquired from freshwater to open ocean sources, and the sulfur-based amino acid, cysteine (CYS). CYS is a known natural precursor of COS and CS2. Results indicated that COS formation did not vary strongly with DOM type, although small impacts were observed on the kinetic patterns. COS formation also increased with increasing CYS concentration but decreased with increasing DOM concentration. Quenching experiments indicated that ˙OH was not involved in the rate-limiting step of COS formation, whereas excited triplet states of DOM (3CDOM*) were plausibly involved, although the quenching agents used to remove 3CDOM* may have reacted with the CYS-derived intermediates as well. CS2 was not formed under any of the experimental conditions. Overall, DOM-containing synthetic waters had a limited to no effect towards forming COS and CS2, especially when compared to the higher concentrations formed in sunlit natural waters, as examined previously. The reasons behind this limited effect need to be explored further but may be due to the additional water quality constituents present in these natural waters. The findings of this study imply that multiple variables beyond DOM govern COS and CS2 photoproduction when moving from freshwaters to open ocean waters.

The rising trend in water conservation has led to the use of water-efficient fixtures for residential potable water systems, which raises concerns about increasing water age and degraded water quality at the tap.

Wirelessly controlled nanorobots have the potential to perform highly precise maneuvers within complex in vitro and in vivo environments. Flagellar nanorobots will be useful in a variety of biomedical applications, however, to date there has been little effort to investigate essential kinetic behavior changes related to the geometric properties of the nanorobot and effects imparted to it by nearby boundaries. Flagellar nanorobots are composed of an avidin-coated magnetic nanoparticle head (MH) and a single biotin-tipped repolymerized flagellum that are driven by a wirelessly generated rotating magnetic field. Nanorobots with different MHs and flagellar lengths were manually guided to perform complex swimming trajectories under both bright-field and fluorescence microscopy visualizations. The experimental results show that rotational frequency, handedness of rotation direction, MH size, flagellar length, and distance to the bottom boundary significantly affect the kinematics of the nanorobot. The results reported herein summarize fundamental research that will be used for the design specifications necessary for optimizing the application of helical nanorobotic devices for use in delivery of therapeutic and imaging agents. Additionally, robotic nanoswimmers were successfully navigated and tracked in 3D using quantitative defocusing, which will significantly improve the efficiency, function, and application of the flagellar nanorobot.