Temis (France)

O Espectro óculo-aurículo-vertebral (EOAV), também conhecido como Microssomia Craniofacial ou Síndrome de Goldenhar, é uma condição congênita rara que apresenta ampla heterogeneidade fenotípica e etiológica.Esta condição clínica ocorre por um defeito no desenvolvimento do primeiro e segundo arcos faríngeos, acometendo principalmente orelhas, olhos, boca, maxila, mandíbula e coluna cervical.Cardiopatias congênitas e anomalias geniturinárias, entre outras, também são descritas.Os critérios clínicos para diagnóstico ainda não são consenso, mas incluem principalmente a presença de microtia e (ou) apêndices pré-aurículares com microssomia hemifacial.Alguns estudos recentes têm investigado desequilíbrios genômicos em indivíduos com essa condição, sendo os mais frequentes aqueles que envolvem a região 22q11.2.O objetivo deste trabalho foi investigar desequilíbrios genômicos em indivíduos com fenótipo sugestivo de EOAV.A casuística foi composta por 30 indivíduos com essa hipótese diagnóstica.A triagem inicial da região 22q11.2foi realizada pela técnica de MLPA (Multiplex Ligationdependent Probe Amplification) que revelou desequilíbrios nessa região em três indivíduos.No entanto, somente um foi classificado como patogênico (1/30 -3,3%).Nos casos em que foram encontradas alterações por MLPA e nos casos com anomalias major adicionais, desequilíbrios genômicos em todo o genoma foram investigados pela técnica de Análise Cromossômica por microarray (ACM) utilizando o chip CytoScan 750K Array (Affymetrix®).Encontrou-se desequilíbrios genômicos em cinco indivíduos, sendo que em dois as alterações

The Proper Orthogonal Decomposition (POD) combined with the (Discrete) Empirical Interpolation Method (DEIM) has been successfully used to reduce the computation time of nonlinear Finite Element (FE) problems. The DEIM enables to alleviate the complexity cost of the nonlinear terms. In this communication, the Best Points Interpolation Method (BPIM) is compared with the DEIM in the case of nonlinear magnetostatics.

This paper shows the importance of Serbian Orthodox confessional primary schools to maintain continuity in the process of upbringing and education of the Serbs in Romania, as well as their outstanding role in preserving traditions, national and cultural identintety. The central questions of work related to the operation and organization of the Serbian Orthodox confessional elementary schools, primarily with the pedagogical aspect, in terms of their curricula, textbooks, teaching organizations, as well as control of work and school financing. Serbian Orthodox confessional school during the entire period of its existence, accompanied by numerous problems and difficulties. The establishment and development of school followed by poor material conditions for educational work, a lack of qualified personnel, war (no) opportunities and poverty of the majority Serbian population, which is in a complex constellation of post-war socio-political circumstances, led to the abolition of these schools. Although they worked in very difficult conditions, as the only schools where the teaching is performed in the native language, they have drawn a significant mark on the part of achieving continuity in education, preservation of culture and tradition of the Serbian population in Romania.

According to Condition Based Maintenance practitioners, various activities, ranging from data collection through the recommendation of specific maintenance actions, must be carried out to perform predictive maintenance. Nevertheless, in practice, (and in spite of recommendations like those ones of the OSA-CBM standard), defining and implementing a computer software system for CBM is not a trivial task. That can be mostly explained by the necessity of providing a distributed application that enables to share data and information in an easy but effective manner in-between various actors from various industrial plants. Following that, the aim of the paper is to describe a collaborative software that has been developed in the society e-m@systec. Its simple architecture, as well as its evolving and customizable capabilities make the global information system as useful for distributed applications. The usage of JEE technology improves the portability of the system. This software is well adapted to support predictive maintenance strategies. Thereby and as for an illustration, an example related to a prognostic problem is also described.

Abstract In Yakoubi [2010] and Lenczner et al. [2010] we developed a theoretical framework of diffusive realization for state-realizations of some linear operators. Those are solutions to certain operator linear differential equations in one-dimensional bounded domains. We also illustrated the theory and developed a numerical method for a Lyapunov equation arising from optimal control theory of the heat equation. However, the principles of our numerical methods were only sketched, and now we provide more details. Then, we do not only provide validation results of the method, but we also report our experience in its implementation on a Field Programmable Gate Arrays (FPGA), for the purpose of promoting embedded real-time computation.

The Europe Media Monitor system (EMM) gathers and aggregates an average of 50,000 newspaper articles per day in over 40 languages. To manage the information overflow, it was decided to group similar articles per day and per language into clusters and to link daily clusters over time into stories. A story automatically comes into existence when related groups of articles occur within a 7-day window. While cross-lingual links across 19 languages for individual news clusters have been displayed since 2004 as part of a freely accessible online application (http://press.jrc.it/NewsExplorer), the newest development is work on linking entire stories across languages. The evaluation of the monolingual aggregation of historical clusters into stories and of the linking of stories across languages yielded mostly satisfying results.