Tianjin Stomatological Hospital

The primary objective of this study was to establish a three-dimensional fluid-structure interaction (FSI) model to compare the biomechanical effects of three distinct breathing modes-nasal (NA), oronasal (ONA), and oral (OA) ventilation-on upper airway dynamics in mouth-breathing patients. A key aim was to investigate a potential biomechanical link between mode-specific hydrodynamic forces and the soft tissue remodeling associated with adenoidal facies. Mouth-breathing volunteer was selected, and cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) images were collected. Subsequently,3D (Three-Dimensional) finite element models of the upper airway, oral airway, soft palate, and tongue body were reconstructed. Numerical simulations of the flow fields of the three different breathing modes, named nasal ventilation, oral nose ventilation, and oral ventilation, were performed using finite element analysis software. The simulations revealed distinct, mode-specific biomechanical environments. Oral breathing (OA) generated significantly higher airflow velocity and stronger negative pressure in the palatopharyngeal and epiglottic regions compared to nasal and oronasal breathing. This led to pronounced posterior-inferior displacement of the tongue and increased deformation of the soft palate. In contrast, nasal breathing produced turbulence confined primarily to the nasal cavity. The model successfully captured the transition to turbulent flow in the pharynx during oral breathing. This preliminary simulation suggests that, within the constraints of our model, oral breathing is associated with increased airflow velocity, higher negative pressure in the palatopharyngeal and epiglottic regions, and a greater posterior displacement of the tongue. These factors may collectively increase the susceptibility to pharyngeal airway collapse.

ABSTRACT In the current field of medical research, oxidative stress‐induced damage to the body has become a significant contributor to the development of many diseases and has garnered extensive attention from the academic community. Reactive oxygen species (ROS), as key mediators in the process of oxidative stress, can cause severe damage to body tissues when their excessive accumulation occurs. Therefore, exploring efficient antioxidant strategies has become an urgent task in medical and scientific research. Currently, numerous. Studies have shown that selenium nanoparticles (SeNPs) can efficiently scavenge excessive ROS in the body, demonstrating great application potential in the field of antioxidant therapy. At the same time, the in situ thermosensitive hydrogel drug delivery system has gradually occupied an important position in the field of drug delivery due to its thermosensitivity and injectability. Based on the above research results, we have developed an innovative in situ injectable thermosensitive hydrogel system—F127/HA‐SeNPs. This system combines F127 and hyaluronic acid as stable and efficient carriers, successfully loading SeNPs with strong antioxidant efficacy. This hydrogel exhibits thermosensitivity, injectability, adhesiveness, excellent biocompatibility, and antioxidant properties. Most importantly, relying on the loaded SeNPs, this hydrogel system exhibits a powerful and continuously stable ROS scavenging ability, effectively protecting cells from oxidative stress damage and improving mitochondrial dysfunction, thereby providing a practical and highly promising treatment solution for oxidative stress‐related diseases. Its material properties and functional mechanisms endow it with good application value and development prospects during the process of disease intervention.

BackgroundExisting research indicates that Chinese nurses generally have a low level of humanistic care competence, and the humanistic care services provided to patients are often insufficient. In dental specialty settings, which primarily operate on an outpatient basis with limited inpatient services, nurses have fewer opportunities to deliver humanistic care, potentially reducing patient satisfaction. This study aims to investigate the current status and influencing factors of humanistic care competence among dental specialty nurses, providing a theoretical basis for developing targeted training programs.MethodsThis cross-sectional study was conducted from April to May 2025 using a convenience sampling method. Nurses from a tertiary stomatological hospital in Xiamen, were recruited. Data were collected using a general information questionnaire, the Caring Ability Inventory (CAI), and the General Self-Efficacy Scale (GSES). The descriptive analysis, independent samples t-test and analysis of variance (ANOVA), Pearson correlation tests, spearman correlation tests, multiple linear regression analysis were employed in data analysis.ResultsA total of 181 nurses participated in the study (179 female, 2 male), with a questionnaire response rate of 90.5%. The overall score of humanistic care competence among dental nurses was 175.44 ± 21.51 (range: 101–240). Sub-dimension scores included cognition (59.83 ± 11.07), courage (68.33 ± 11.76), and patience (47.28 ± 5.13). The average GSES score was 28.85 ± 6.68 (range: 14–40). Multiple linear regression analysis revealed that senior staff nurse (β = 16.371, P < 0.001), nurse supervisor (β = 18.336, P < 0.001), no humanistic care training (β=-24.416, P < 0.001), and self-efficacy (β = 0.518, P = 0.009) were independent predictors of humanistic care ability.ConclusionHumanistic care competence among dental specialty nurses is at a relatively low level. Clinical training programs should incorporate humanistic awareness as a core element, and effective strategies should be implemented to enhance nurses’ self-efficacy in order to improve their ability to provide humanistic care.

Root canal irrigation is a crucial component of endodontic treatment, yet it is often insufficiently addressed in dental education. Although its clinical significance is well recognized, dedicated simulation platforms for irrigation training remain scarce. This study aimed to develop a virtual simulation system for root canal irrigation and to evaluate its effectiveness in improving dental students' knowledge and procedural competence. Thirty-four dental students (26 undergraduates and 8 postgraduates) participated in this prospective study. After receiving standardized theoretical instruction, all students completed baseline and post-training assessments using three-dimensional printed tooth models. Training sessions were conducted with the newly developed virtual simulation system. Outcome measures included theoretical knowledge scores, pre- and post-training practical scores, and simulation-based performance scores. Data were analyzed using paired t-tests, Pearson correlation analyses, subgroup comparisons, and a post-hoc power analysis conducted with G*Power 3.1. In addition, a 26-item Likert-scale questionnaire was administered to assess usability and learner perceptions. Significant improvements were observed in both theoretical knowledge (mean increase: 0.59 points, p < 0.001) and practical performance (mean increase: 3.15 points, p < 0.001). Simulation-derived performance scores demonstrated a strong positive correlation with post-training practical outcomes (r = 0.73, p < 0.001). Questionnaire analysis indicated consistently high ratings for learning effectiveness, usability, instructional value, and overall satisfaction, with Cronbach's alpha values above 0.80 across all domains. This virtual simulation system shows preliminary value in improving theoretical and procedural learning in root canal irrigation, with strong acceptability among students. Further validation through larger, multi-center and long-term studies is needed to establish its broader educational impact.

This study aimed to investigate the efficacy of a novel combination of the neodymium-doped yttrium aluminum perovskite (Nd:YAP) laser and deoxyribonuclease I (DNase I) in eliminating dual-species biofilms from dentinal surfaces using a three-dimensional (3D)-printed lateral canal model. A computational fluid dynamics model was used to assess the impact of needle insertion depth on irrigant flow within the lateral canal model. Enterococcus faecalis and Fusobacterium nucleatum biofilms were cultured on dentin discs. Scanning electron microscopy and confocal laser scanning microscopy (CLSM) were used to investigate the influence of Nd:YAP laser and DNase I on the antimicrobial activity of 1% sodium hypochlorite (NaOCl). The CLSM results demonstrated a significant reduction in the formation of dual-species biofilms among viable bacteria treated with the combination of Nd:YAP laser and DNase I, compared to other treatment groups. As the needle insertion depth decreased, the irrigant velocity in the lateral canal decreased, resulting in the attachment of a greater number of viable bacteria. The combination of Nd:YAP laser and DNase I effectively addresses the limitations of single supplementary treatment by enhancing irrigant penetration and biofilm disruption within the lateral canal model, presenting a promising strategy for in vitro disinfection of lateral canal structures.

To investigate the association between Circadian Syndrome (CircS)-a metabolic syndrome extension incorporating circadian disruption-and periodontitis in U.S. adults, and to identify high-risk subgroups for targeted prevention. We analyzed 5,343 U.S. adults from NHANES 2009-2014. Periodontitis was defined by probing depth and clinical attachment level; CircS required ≥ 4 of 7 components (waist circumference, triglycerides, HDL-C, BP, fasting glucose, sleep ≤ 6h, PHQ-9 ≥ 5). Weighted multivariable logistic regression, subgroup analyses and Propensity Score Matching (PSM) were used. CircS prevalence was 59.8%. After adjusting for sociodemographics and lifestyle, CircS was associated with 29% higher odds of periodontitis (OR = 1.29, 95%CI:1.08-1.53). Subgroups with elevated risk included females (OR = 1.499), non-Hispanic Whites (OR = 1.352), unmarried individuals (OR = 1.367), non-smokers (OR = 1.308), and those with low education (OR = 1.880). PSM sensitivity analysis confirmed robustness (OR = 1.22, p = 0.048). CircS independently predicts periodontitis risk, underscoring circadian-metabolic dysregulation as a shared pathway for oral-systemic disease. Integration of circadian health screening into diabetes/metabolic care may enhance periodontitis prevention, particularly in high-risk subgroups.