Titan Pharmaceuticals (United States)

The present investigation is aimed at studying the influence of alumina and silicon nitride reinforcement particles in addition to the Al 7075 alloy on the hardness, wear, tensile, and impression creep behaviour. Three different composite specimens such as Al 7075 + 5 % alumina, Al 7075 + 5 % Silicon nitride, and Al 7075 + 2.5 % Silicon nitride + 2.5 % Alumina were fabricated using a stir casting process and the prepared composites were subjected to hardness, dry sliding wear test using pin on disc tribometer, tensile testing and impression creep tests. From the results, it was observed that the hardness of the Al 7075 alloy increases with the addition of both silicon nitride and alumina and Al 7075 + 2.5 % Silicon nitride + 2.5 % Alumina exhibited the maximum hardness of the composite specimens. Al 7075 + 2.5 % Silicon nitride + 2.5 % Alumina showed a 75% increase in wear resistance in comparison with the Al 7075 alloy and it also shows an improvement in creep and tensile properties.

Software is a fundamental pillar of modern scientiic research, not only in computer science, but actually across all elds and disciplines. However, there is a lack of adequate means to cite and reference software, for many reasons. An obvious rst reason is software authorship, which can range from a single developer to a whole team, and can even vary in time. The panorama is even more complex than that, because many roles can be involved in software development: software architect, coder, debugger, tester, team manager, and so on. Arguably, the researchers who have invented the key algorithms underlying the software can also claim a part of the authorship. And there are many other reasons that make this issue complex. We provide in this paper a contribution to the ongoing eeorts to develop proper guidelines and recommendations for software citation, building upon the internal experience of Inria, the French research institute for digital sciences. As a central contribution, we make three key recommendations. (1) We propose a richer taxonomy for software contributions with a qualitative scale. (2) We claim that it is essential to put the human at the heart of the evaluation. And (3) we propose to distinguish citation from reference.

Intrastriatal transplantation of gelatin microcarrier-attached human retinal pigment epithelial cells (hRPE-GM) may represent an alternative source for cell therapy in Parkinson disease (PD). The use of human retinal pigment epithelial (hRPE) cells in PD relies on the capacity of these cells to produce l-dopa as an intermediate product in the eumelanin synthesis pathway. We investigated the behavioral effects of hRPE-GM implants on forelimb use asymmetries and hindlimb motor deficits in unilateral and bilateral 6-hydroxydopamine (6-OHDA) rat models of PD. We report that intrastriatal unilateral implantation of hRPE-GM in rats with 6-OHDA nigrostriatal lesions produce an amelioration of the contralateral forelimb disuse and the contralateral hindlimb deficits. These results further support the possibility that implantation of cultured hRPE cells may be a promising therapeutic option for patients with PD.

Gene transfer of a truncated variant of the retinoblastoma (RB) gene encoding a M(r) 94000 protein that lacks the NH(2)-terminal 112 amino acid residues, termed RB94, has been shown to inhibit proliferation of several human tumor cell types. We have assessed its therapeutic effectiveness on pancreatic cancer, one of the most aggressive and therapy-resistant types of cancer. For this purpose, preclinical studies aimed to evaluate the therapeutic potential of RB94 gene transfer in pancreatic cancer were carried out. We have compared the antiproliferative effects of adenovirus-mediated gene transfer of RBwt and RB94 at the in vitro and in vivo levels in three RB-positive human pancreatic tumor cell lines: (a). NP-9; (b). NP-18; and (c). NP-31. We have also examined their effects on cell cycle and their capacity to induce apoptosis. In vitro results indicate that RB94 gene transfer has stronger antiproliferative effects compared with RBwt. RB94 transduction correlated with accumulation at the S-G(2) phase of the cell cycle in the three cell lines tested and induction of apoptosis in two of them. In vivo studies show significant decreases in the growth rate of tumors treated with Ad-RB94 when compared with those treated with Ad-RBwt. Moreover, terminal deoxynucleotidyl transferase-mediated nick end labeling analyses of Ad-RB94-treated tumor sections revealed that only RB94 is able to significantly induce apoptosis. RB94 gene expression has antiproliferative effects also in human pancreatic tumor cells, being more effective than wild-type RB in preventing tumor growth.

We generated an anti-idiotype antibody, designated CeaVac, that is an internal image of the carcinoembryonic antigen (CEA). We previously demonstrated that the majority of patients with advanced colorectal cancer generate specific anti-CEA responses. The purpose of the current study was to treat patients with surgically resected colon cancer with CeaVac to determine the immune response and clinical outcome to treatment with vaccine. We also compared the immune responses between patients treated with fluorouracil (5-FU) chemotherapy regimens plus vaccine versus vaccine alone. Thirty-two patients with resected Dukes' B, C, and D, and incompletely resected Dukes' D disease were treated with 2 mg of CeaVac every other week for four injections and then monthly until tumor recurrence or progression. Fourteen patients were treated concurrently with 5-FU chemotherapy regimens. All 32 patients entered onto this trial generated high-titer immunoglobulin G and T-cell proliferative immune responses against CEA. The 5-FU regimens did not have a qualitative or quantitative effect on the immune response. Three of 15 patients with Dukes' B and C disease progressed at 19, 24, and 35 months. Seven of eight patients with completely resected Dukes' D disease remained on study from 12 to 33 months; one patient with resected Dukes' D disease relapsed at 9 months. One patient with incompletely resected Dukes' D disease remained on study at 14 months without evidence of progression; eight experienced disease progression at 6 to 31 months. CeaVac consistently generated a potent anti-CEA humoral and cellular immune response in all 32 patients entered onto this trial. A number of very high-risk patients continue on study. 5-FU regimens, which are the standard of care for patients with Dukes' C disease, did not affect the immune response. These data warrant a phase III trial for patients with resected colon cancer.

Eighty-four brightest cluster members (BCMs) in the complete sample of high Galactic latitude nearby Abell clusters of Hoessel, Gunn, and Thuan (HGT) are investigated. The stellar populations in BCMs using near-infrared and optical-near-infrared colors are studied. Brighter BCMs have redder (J-K) and (V-K) colors, suggesting a metallicity increase in brighter galaxies. The larger dispersion of their colors implies that BCMs possess more heterogeneous stellar populations than their lower luminosity counterparts, the normal elliptical galaxies. Special attention is paid to BCMs associated with cooling flows. BCMs with larger accretion rates have bluer (V-K) colors due to ultraviolet excesses and are brighter in the visual wavelength region, but not in the infrared. It is suggested that part of the X-ray emitting cooling gas is converted into high- and intermediate-mass stars emitting in the blue and visible, but not in the infrared. The properties of BCMs as standard candles in the near-infrared are examined and compared with those in the optical.

Autonomous system operations require special con- sideration of real-time constraints and measurement noise, often in demanding environments. Hybrid architectures can take advantage of the features of both heuristic and optimized control theory approaches to obtain results not achievable by architectures of either type taken alone. Heuristic rule-based systems can be used to formulate cost functions for specific tasks and decide the efficiency of calculating such functions relative to using heuristic rules. We discuss considerations that led us to develop hybrid systems,for air, land and sea operations, describe the generic architecture we have developed, and present results of simulation studies.

Spectral measurements of the two BL Lac objects OQ 530 and ON 325 are presented. The measurements were taken at frequencies ranging from radio to ultraviolet. Both sources show spectral curvature between the infrared and ultraviolet frequencies. The intensity and spectral shape of OQ 530 vary, but the spectral shape of ON 325 appears to remain constant during intensity variability. A nonthermal theoretical model of jet emission is developed which incorporates both the spectral and time variability data. The model predicts that ON 325 radiates at X-ray frequencies with Compton radiation dominating over synchrotron emission. The angular size of the jet emission is predicted to be less than 0.1 milli-arcsec at high radio frequencies.