Torrecid (Spain)

To assess the effectiveness and safety of delayed antibiotic prescription (DAP) compared to immediate antibiotic prescription (IAP) and no antibiotic prescription (NAP) in children with uncomplicated respiratory infections. Randomized clinical trial comparing 3 antibiotic prescription strategies. The participants were children with acute uncomplicated respiratory infections attended to in 39 primary care centers. Children were randomly assigned into prescription arms as follows: (1) DAP, (2) IAP, or (3) NAP. Primary outcomes were symptom duration and severity. Secondary outcomes were antibiotic use, parental satisfaction, parental beliefs, additional primary care visits, and complications at 30 days. In total, 436 children were included in the analysis. The mean (SD) duration of severe symptoms was 10.1 (6.3) for IAP, 10.9 (8.5) for NAP, and 12.4 (8.4) for DAP (P = .539), although the differences were not statistically significant. The median (interquartile range) of the greatest severity for any symptom was similar for the 3 arms (median [interquartile range] score of 3 [2-4]; P = .619). Antibiotic use was significantly higher for IAP (n = 142 [96%]) compared to DAP (n = 37 [25.3%]) and NAP (n = 17 [12.0%]) (P < .001). Complications, additional visits to primary care, and satisfaction were similar for all strategies. Gastrointestinal adverse effects were higher for IAP. There was no statistically significant difference in symptom duration or severity in children with uncomplicated respiratory infections who received DAP compared to NAP or IAP strategies; however, DAP reduced antibiotic use and gastrointestinal adverse effects.

Objective: One of the most powerful medications that have very broad aspects of clinical application are the selective serotonin reuptake inhibitors (SSRI). We use SSRI as a first choice agents in treatment of depression, obsessive-compulsive disorders and some anxiety disordes. Objective: To analyze the outcome of treatment of adolescent depresion with SSRI’s, considering the age group, disorder categories, response to treatment and side effects. Methods: A retrospective epidemiological investigation was conducted by means of medical records for all adolescent treated with sertraline during six months period at the Department of Child and Adolescent Psychiatry in Belgrade. The clinical response to treatment was rated by Beck Depression Inventory and Hamilton Depression Rating Scale. Results: 5 boys and 10 girls (mean age 15.7) were treated with sertraline during the first episode of depression; administred doses were 50–75 mg per day. 86% of patients improved, 10% droped out because of economic reasons, and 4% experienced side affects (nausea, vomiting, headache). Conclusion: Sertraline is potent, safe and effective in the treatment of young people with first episode of depression.KeywordsAttention Deficit Hyperactivity DisorderAnorexia NervosaOppositional Defiant DisorderAttention Deficit Hyperactivity Disorder SymptomInternet AddictionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.