- Research Article
8- 10.1046/j.1365-3164.1999.00126.x
The use of compound 48/80 as a positive control in equine intradermal allergy testing.
- Dec 01, 1999
- Veterinary dermatology
- Shipstone + 4 more +4
The macroscopic and microscopic effects following the intradermal injection of the mast cell degranulator compound 48/80 were investigated in horses. It was found that a 1000 μg mL-1 solution of compound 48/80 could be used as an alternative to histamine as a positive control in equine intradermal allergy tests. An inflammatory cell infiltration was noted on histological examination, following compound 48/80 injection. This inflammatory cell pattern was similar to that noted for Type-I hypersensitivity.
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