Twickenham Plating Group (United Kingdom)

Water consumption of concentrating solar power plants for mirror washing is an area of concern from a financial, environmental, and humanitarian perspective, and much effort is being undertaken to reduce this facet of water use.Presented here is a novel plasma generating device that enhances conventional water washing by modifying the surface energy of the mirror samples to produce a hydrophilic surface that more evenly distributes water over the mirror surface.Hybrid plasma washing achieved higher values of reflectance (95.5%) than water washing alone (93.2%), and exhibited an anti-soiling effect when subject to further soiling (78.5% and 75.3% respectively).

Abstract While many evidence‐based tools and measures exist to support child protection practice, in the United Kingdom, there is little evidence of their routine use in casework. This paper reports on a qualitative study exploring the use of such tools with children and families receiving statutory social care services. Fifteen social workers working in child safeguarding teams in two local authorities in Southeast England agreed to incorporate the use of outcome measures into their casework over a 6‐month period. Qualitative data were collected through monthly action learning workshops held separately in each local authority. The results showed how the impact of using the measures was shaped by a combination of institutional factors, practice context and the dynamics of casework. Outcome measures were found to have benefits as well as limitations with respect to partnership working, assessment and decision‐making and overall social work practice. Implications are discussed for the prospects of enhancing the use of evidence‐based tools in statutory social work with children and families.

Every Saturday, thousands of runners worldwide participate in parkrun – a free five-kilometre run/walk event. Delivery relies on volunteers, and parkrunners are encouraged to volunteer regularly. However, volunteer recruitment is often difficult, and this study aimed to investigate the underpinning reasons for this. Data were collected from 6,749 parkrunners using an online survey, including 860 who had never volunteered. In addition to demographic information and views on incentives, non-volunteers were asked to rate agreement level for 18 statements about not volunteering. Main reasons were preferring to run or walk and not having got round to it. Principal component analysis indicated four underlying factors: inertia, self-interest, lack of knowledge and anxiety. Non-volunteers were younger, slower runners and walkers, less frequent parkrun attendees and had become involved more recently than volunteers. Ease of signing up to volunteer and being unsure of the commitment required were barriers. It is recommended that these two issues are addressed to help volunteer recruitment.

I question whether Wachtel’s assertion that there are gaps in the relational literature and residues of a one-person psychology is little more than a reflection of the relational tradition, which encompasses a multiplicity of perspectives. This notwithstanding, his paper helpfully addresses a neglected dimension of clinical practice and provides the opportunity to explore the evolution of Stephen Mitchell’s thinking about the baby as a psychoanalytic metaphor. In doing so, I briefly, if somewhat tangentially, discuss the structure of the inner world, the role of memory in psychoanalysis, the nature of transference, and the extent to which early experiences with caregivers influence adult intimate relationships. To further illuminate Wachtel’s theoretical and therapeutic model, I summarize Mitchell’s (2000) case study of Connie, focusing on his detailed inquiry into her everyday relationship with her husband.

West of London in Richmond and Twickenham, 6000 Belgian refugees developed a flourishing social life, drawn in the context of the national ‘shell crisis’ by employment opportunities at the Pelabon Munitions Works. This article asks why Belgian community life was richer here than almost anywhere else, and explores the significance of refugees’ social interaction for their class and other group identities. Finally, the article seeks to explain why this vast community became completely forgotten locally.

635 Background: About a third of HER2-overexpressing (HER2+) breast cancer pts will develop brain metastases in the course of their disease. Drug access to normal brain and brain metastases is therefore key to prevention and treatment of cerebral metastases. To provide direct evidence of Lap drug access and evaluate whether therapeutic doses of Lap act as a substrate for efflux transporters, thereby increasing Lap concentrations, we performed positron emission tomography (PET) studies with [11C]Lap. Methods: Pts with HER2+ MBC with an ECOG of <3 were grouped into 2 cohorts: with at least one 1-cm diameter brain metastasis or without brain metastases and underwent 90-minute dynamic cranial PET-CT scans after IV administration of a microdose (<1 mg) of [11C]Lap before and after 8 days of oral Lap (1500 mg once daily). Arterial blood samples were performed to assess [11C]Lap radioactivity contribution in blood and plasma, and the fraction of plasma [11C] radioactivity corresponding to metabolites. Tissue time-radioactivity curves (TACs) were generated and [11C]Lap exposure (AUC; area under TAC) derived for normal brain and brain metastases. Signal dissection of the total image activity was performed to remove the contribution of blood volume to the image and the actual tissue contribution due to [11C]Lap obtained. Results: 6 pts (3 with brain metastasis) were recruited. Arterial plasma analysis revealed that [11C]Lap contributed to >80% of activity in plasma at 60 minutes. Tissue data revealed [11C]Lap signal in normal brain was low with no appreciable uptake observed when corrected for blood volume contribution. [11C]Lap uptake was higher in brain metastases compared with normal brain and appreciable, even after correction for tissue blood volume contribution. Uptake was also observed in extra-cranial normal tissue. There was no difference in [11C]Lap uptake in normal brain and metastases between treatment-naïve and post-treatment scans. Conclusions: [11C]Lap uptake in brain metastases was higher than in normal brain. [11C]Lap drug access to brain metastases might therefore indicate possible efficacy against HER2+ brain metastases. Clinical trial information: NCT01290354.

Abstract Aims & Objectives: This paper critically examines the nature and benefits of a therapeutic alliance created between a fluent, bilingual woman who had suffered a period of extreme bullying and her monolingual therapist. Method: The paper uses a case study approach to consider the underpinning psycho‐neurology and describes the theoretical frameworks used to inform the therapeutic process and facilitate recovery. Results: The therapeutic approach proved successful in dealing with the physical, emotional and psychological impact of the bullying and has enabled the subject to return to work successfully. Conclusions: The emotional distancing provided by language switching can be invaluable in enabling a traumatised person to make sense of their experience.

Pro-inflammatory cytokines such as tumour necrosis factor alpha (TNF alpha) have been implicated in the pathogenesis of rheumatoid arthritis (RA), and have therefore become therapeutic targets. An engineered human antibody, CDP571, that neutralizes human TNF alpha was administered intravenously in single doses of 0.1, 1.0 or 10 mg/kg to patients with active RA (n = 24). The effects of the antibody were compared in a double-blind fashion with those of placebo (n = 12). In an open continuation phase patients were given either 1.0 or 10 mg/kg. We found that CDP571 was well tolerated and caused reductions in markers of disease activity such as erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP): this was confirmed by a reduction in the disease activity score (DAS). There was a reduction in the number of tender joints, maximal in degree and duration after 10 mg/kg. Patients also documented a reduction of pain and relief of arthritis symptoms. The effects of 10 mg/kg CDP571 on ESR, CRP, tender joints, pain and symptom relief compared to placebo were statistically significant at weeks 1 or 2. The continuation phase, although open, confirmed both the safety and the beneficial effects of CDP571 in active RA. In conclusion CDP571, an engineered human anti-TNF alpha antibody, is well tolerated and, after a single dose of 10 mg/kg, provides improvements in symptoms, signs and serological markers of disease activity in patients with active RA.