Universidad Señor de Sipán

Background: Burnout and job satisfaction are widely studied phenomena within the field of occupational health, particularly among nursing professionals exposed to high work demands. Work engagement has been identified as a potential mediator that may buffer the negative effects of burnout on job satisfaction. However, in the Peruvian context, empirical evidence on this relational dynamic remains limited. Objective: The objective of this study is to examine the mediating role of work engagement in the relationship between burnout and job satisfaction among Peruvian nurses using a structural equation modeling (SEM) approach. Methods: An explanatory study was conducted with a sample of 230 Peruvian nurses (M = 41.22, SD = 11.65). Data were analyzed using structural equation modeling. Results: Burnout showed significant negative correlations with work engagement (r = -0.47, p < 0.01) and job satisfaction (r = -0.41, p < 0.01), while work engagement was positively associated with job satisfaction (r = 0.79, p < 0.01). The structural model demonstrated a good fit (CFI = 0.96, TLI = 0.95, RMSEA = 0.06, and SRMR = 0.04). The model also indicated solid overall fit and revealed a significant indirect effect of burnout on job satisfaction through engagement, accounting for approximately 24% of the variance in engagement and 80% of the variance in job satisfaction. Conclusions: The findings confirm that work engagement fully mediates the relationship between burnout and job satisfaction among Peruvian nurses, serving as a key protective psychosocial resource. These results reinforce the Job Demands-Resources (JD-R) model and highlight the importance of implementing organizational interventions aimed at strengthening work engagement as a strategy to improve satisfaction and well-being in demanding healthcare settings.

Background: This investigation compared the efficacy and safety of fexuprazan 40 mg and esomeprazole 40 mg in patients with acid reflux-related disorders, including erosive esophagitis (EE) and laryngopharyngeal reflux disease (LPRD). Methods: A systematic search was conducted across five databases until January 2025. Primary outcomes included esophageal lesion healing, complete resolution of symptoms (CRS), and 24 h symptom-free days. Meta-analyses used random-effects models with the inverse variance method. The Risk of Bias 2.0 tool and the certainty of evidence (CoE) using GRADE methodology were assessed. Results: Three randomized controlled trials (n = 695) conducted in Asian countries were included. Fexuprazan may have little to no effect compared to esomeprazole on EE healing rate at 4 weeks (RR 1.02, 95% CI 0.93 to 1.12, I2 = 0%, n = 2 studies, CoE very low) and 8 weeks. No significant differences were found between treatments regarding CRS at 1 week (RR 1.29; 95% CI: 0.84 to 1.99; I2 = 0%; n = 2 studies; CoE very low) and 8 weeks, or in the 24 h symptom-free days at 1 week (MD 2.67 days, 95% CI -2.76 to 8.10, I2 = 41%, n = 2 studies, CoE very low) and 8 weeks. Fexuprazan also showed little to no effect on treatment-emergent adverse events (RR 1.00, 95% CI 0.83 to 1.20, I2 = 0%, n = 3 studies, CoE very low). Nonetheless, the evidence for all outcomes was rated as very uncertain. Conclusions: Fexuprazan 40 mg may provide similar efficacy compared to esomeprazole 40 mg in EE, with a comparable safety profile to esomeprazole in EE and LPRD patients. However, the evidence is highly uncertain, requiring further studies.

The objective of this study was to analyze the impact of mobile learning (m-learning) on strengthening the English language skills of adolescent students in northern Peru. A mixed approach was used, employing a quasi-experimental pretest-posttest design with a single group, complemented by a qualitative interpretive analysis. The intervention consisted of the use of educational mobile applications during regular English classes, integrated with active and contextualized teaching strategies. The sample consisted of 120 students from public schools in different cities in northern Peru, a region that faces structural challenges in terms of connectivity and equitable access to technological resources. The results showed significant improvements in the language skills assessed, with average increases of more than 3 points between the pre-test (M = 10.2, SD = 2.1) and the post-test (M = 14.0, SD = 2.0), highlighting greater progress in listening comprehension. It is concluded that mobile learning, when implemented with adequate pedagogical planning and adapted to the conditions of the local educational environment, is an effective tool for improving English proficiency in secondary school students. The importance of this study lies in the fact that it provides empirical evidence from a context that has been little explored in the international literature, highlighting the potential of m-learning as a strategy for reducing educational gaps and expanding access to learning experiences.

Introduction: Smoking is a known risk factor for cardiovascular diseases, but its specific relationship with blood pressure remains a topic of debate. Recent studies suggest that different aspects of smoking behavior, such as intensity and duration, may have distinct effects on blood pressure. Objective: To evaluate the association between different measures of smoking behavior and blood pressure in the Peruvian population. Methodology: A cross-sectional analysis was conducted using data from the Peruvian Demographic and Family Health Survey (DHS) from 2018 to 2023. Multiple aspects of smoking were assessed, including current smoking status, intensity, duration, and the global tobacco index. Multiple linear regression models were used to examine the association between these measures and systolic (SBP) and diastolic (DBP) blood pressure, adjusting for sociodemographic and health variables. Results: A significant association was found between smoking intensity and elevated blood pressure. Smokers of 20 or more cigarettes per day showed an increase of 6.82 mmHg in SBP (95% CI: 2.90, 10.75) and 5.07 mmHg in DBP (95% CI: 2.44, 7.70) compared to non-smokers. The global tobacco index and smoking duration showed weaker and more variable associations with blood pressure. Conclusions: Smoking intensity, rather than other measures of smoking behavior, is more strongly associated with blood pressure levels. These findings highlight the importance of considering smoking intensity in cardiovascular risk assessment and suggest that prevention strategies should focus not only on cessation but also on reducing smoking intensity.

This study analyzes the influence of digital marketing on the success of digital ventures in Peru by integrating channels, applications, online presence, and business models into a causal model. Using a quantitative approach with a structural equation model appliedto 388 entrepreneurs, digital marketing was found to have a positive impact on entrepreneurship (β=0.5805, p&lt; 0.001), channels (β=0.7499, p&lt;0.001), and applications (β=0.4962, p&lt;0.001). Similarly, entrepreneurship improves online presence (β=0.5086, p&lt;0.001) and promotes alternative business models (β=0.2857, p&lt;0.001). These results demonstrate the relevance of this topic by overcoming fragmented approaches, offering empirical evidence, and proposing strategies to strengthen the competitiveness, sustainability, andgrowth of digital ventures in the Peruvian context.

High-intensity ultrasound-assisted extraction was used to extract total soluble phenols, flavonoids, and anthocyanins from Beta vulgaris stems, and to evaluate their antioxidant activities (DPPH, ABTS, and FRAP). The effect of extraction time (X1: 2, 4, and 6 min), ultrasound power (X2: 80%, 90% and 100%), and liquid-to-solid ratio (X3: 10:1, 15:1, and 20:1 mL/g) was investigated using response surface methodology. The high-intensity ultrasound-assisted extraction models for all responses were adjusted to a 2nd-order polynomial equation (R2 = 0.94 - 0.99, lack of fit &gt; 0.05). Optimal high-intensity ultrasound-assisted extraction conditions differ for each response, X1: 3.08 min, X2: 100%, and X3: 17.32:1 mL/g for total soluble phenols, X1: 5.99 min, X2: 95.04% and X3: 17.28:1 mL/g for total flavonoids, and X1: 6 min, X2: 92.24%, and X3: 12.97:1 mL/g for total anthocyanins. Moreover, all evaluated conditions exhibited antioxidant properties by DPPH, ABTS, and FRAP. Furthermore, the validated high-intensity ultrasound-assisted extraction conditions (3.08 min for extraction time, 100% power ultrasound, and 17.32 mL/g of liquid-to-solid ratio) yielded 2.35 times higher soluble phenols content than conventional extraction method (magnetic stirring at 400 rpm for 60 min), with higher (p ˂ 0.05) flavonoids, ABTS, and FRAP values, and similar values (p &gt; 0.05) for anthocyanins and DPPH. Furthermore, shikimic, protocatechuic, 4-hydroxybenzoic, gallic, chlorogenic, neochlorogenic, and trans-ferulic acids were higher under high-intensity ultrasound-assisted extraction than conventional extraction according to the HPLC analysis. It demonstrated that high-intensity ultrasound-assisted extraction is an efficacious technology for extracting bioactive molecules. In addition, future research could focus on isolating and purifying the phenolic compounds extracted from B. vulgaris stem powder, which have potential applications in food and non-food industries. HIGHLIGHTS Beta vulgaris stems are a source of phytochemicals Ultrasound is a viable technology for extracting bioactive compounds Beta vulgaris extracts exhibited antioxidant properties GRAPHICAL ABSTRACT

This paper aimed to analyze the central role of the principle of preservation of the Andean community legal order as a fundamental guarantor of legal certainty within the Andean Community integration system. The methodology employed was a documentary analysis with a systematic and teleological approach, critically reviewing doctrinal sources on Andean community law and theories on legal certainty. The results indicate that, despite the conceptual complexity of legal certainty, it is primarily based on the principle of preservation of the legal order. This principle, through the binding nature and intangibility of norms and the actions of the Court of Justice of the Andean Community, provides the necessary stability and predictability. The main conclusion is that the preservation of legal order is not an accessory feature but the fundamental pillar that endows legal certainty with effectiveness and credibility within the Andean Community, being an indispensable condition for community law to fulfill its integrative purposes with certainty and confidence.

This study aimed to develop a deep learning-based application for the automatic detection of nutritional deficiencies in coffee plants through the analysis of in-field leaf images. Images were collected from farms in the Shipasbamba district and classified into six deficiency types: nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), magnesium (Mg), and iron (Fe). A total of 2643 leaves were labeled and preprocessed for model training. Several YOLO architectures were evaluated, with YOLO11x achieving the best performance after 100 epochs, reaching a precision of 88.98%, recall of 88.54%, F1-Score of 88.76%, and mAP50 of 92.68%. An interactive web application was developed to allow real-time image upload and processing, providing both graphical and textual feedback on detected deficiencies. These results demonstrate the model’s effectiveness for automated diagnosis and its potential to support coffee growers in timely, data-driven decision-making, ultimately improving nutrient management and reducing production losses.