Universidad del Valle de Orizaba

Antecedentes: La secuencia rápida de intubación en un escenario poco controlado es un procedimiento de alta complejidad, con varias etapas durante su realización, por lo que cualquier contratiempo aumenta la dificultad al asegurar la vía aérea. Objetivo: Identificar los factores de riesgo asociados a complicaciones en la secuencia de intubación rápida. Material y método: Se trató de un estudio de tipo retrolectivo, transversal, observacional, descriptivo, se buscó 103 expedientes de pacientes de urgencias de Hospital General Regional Orizaba, Veracruz, México; con secuencia rápida de intubación, identificando los factores asociados a complicaciones durante el proceso; analizando resultados con estadística descriptiva, pruebas de normalidad, explicándolas con gráficas y tablas. Resultados: La mayoría de los pacientes 83 (80.58%) fueron intubados en el primer intento, 2 intentos: 11 (10.67%), siendo 9 (8.75%) los que requirieron un tercer intento o más; aquellos que no tuvieron ninguna limitación para la alineación de los ejes, y que en la laringoscopia directa se visualizó cuerdas vocales, fueron 79 (76.69%), por lo tanto, se obtuvo una X2 significativa = 42.79, p < 0.001; cabe destacar que el personal no adscrito tuvo mayor tasa de éxito al primer intento. Conclusiones: las condiciones directamente relacionadas al paciente que tiene una vía aérea difícil requieren un mayor número de intentos durante la secuencia rápida de intubación.

This study aimed to synthesize and characterize cassava starch-based (S) scaffolds functionalized with decellularized extracellular matrix (dECM) and isosorbide dinitrate (ISDN) for wound healing. The scaffolds were synthesized via the casting method and evaluated for physicochemical, mechanical, and morphological properties, as well as ISDN release and hemocompatibility. Swelling and degradation tests revealed a biphasic behavior, with high water absorption followed by controlled degradation. The ISDN release followed a biphasic pattern, fitting the Korsmeyer-Peppas model. Hemolysis tests confirmed biocompatibility, with hemolysis levels below 2%. Among the formulations, the scaffold containing 12.5% ECM and 40 mg ISDN exhibited optimal mechanical stability, controlled drug release, and biocompatibility. These findings suggest that starch/ECM/ISDN scaffolds hold potential for wound healing applications. Further studies should focus on in vivo evaluation and cytotoxicity assessments to confirm their clinical applicability.

Ushbu maqolada agiografik manbalar tushunchasi va ularning paydo bo‘lish tarixi haqida ma’lumotlar tahlil etilgan. Shuningdek, O‘rta Osiyoda yozilgan agiografik manbalar va ularning turlari haqidagi ma’lumotlar tahlil etilib, manbaviy ahamiyatiga tavsif berilgan. Maqolada, ayniqsa, musulmon shayxlari, olimlarlarining hayotiga oid manbalar tahlil qilinadi. Ushbu manbalar, O‘rta Osiyoning diniy-ijtimoiy hayotini, madaniy an’analari va ma’naviy qadriyatlarini yoritish bilan birga, mintaqa tarixini yanada chuqurroq tushunishga yordam beradi.

The purpose of this study was to report the incidence of iatrogenic sural nerve injury in a large, consecutive sample of surgically managed ankle fractures and to identify factors associated with sural nerve injury and subsequent recovery. We hypothesize that a direct posterior approach may be associated with higher risk of iatrogenic sural nerve injury. A retrospective cohort study of 265 skeletally mature patients who sustained ankle fractures over a 2-year period was done. All were treated with open reduction and internal fixation of fractured malleoli. Patient, injury, and treatment features were documented. The presence (n = 26, 9.8%) of sural nerve injury and recovery of sural nerve function were noted. All 26 sural nerve injuries were iatrogenic, occurring postoperatively after open reduction and internal fixation. Patients who sustained sural nerve injuries had more ankle fractures secondary to motor vehicle collisions (23.1% versus 9.2%), more associated trimalleolar fractures (69.2% versus 33.9%), and more Orthopaedic Trauma Association/AO 44B3 fractures (57.7% versus 25.1%), all P < 0.05. A posterior approach to the posterior malleolus through the prone position was used in 20.4% of patients. All 26 of the sural nerve injuries (100%) occurred when the patient was placed prone for a posterior approach, P < 0.001. Therefore, 26 of the 54 patients (48%) treated with a posterior approach sustained an iatrogenic sural nerve injury. 62% of patients had full recovery of sural nerve function with no residual numbness, and patients with nerve recovery had fewer associated fracture-dislocations (23.1% versus 100%, P = 0.003). A posterior approach for posterior malleolus fixation was associated with a 48% iatrogenic sural nerve injury rate, with 62% recovering full function within 6 months of injury. Morbidity of this approach should be considered, and surgeons should be cautious with nerve handling. Level III, Therapeutic.

La poesía de Lorca ha tenido una influencia enorme en la cultura literaria de la URSS, especialmente a partir de los años 60 a raíz del «deshielo» de Jruschov. En esta época, Lorca prácticamente personificaba toda la poesía española para la sociedad rusa y las traducciones del poeta al ruso crearon su propia corriente literaria de diálogo intercultural. &#x0D; El objetivo de esta investigación es estudiar dicho fenómeno a través del prisma de los cambios socioculturales en la Unión Soviética y demostrar cómo la recepción inicial de Lorca, en principio totalmente propagandística, se convierte con el paso de tiempo en una vía de inserción de las ideas que luchan contra la misma propaganda. También se estudia la aparición del «mito» durante el proceso de recepción, la tergiversación de la imagen del poeta y de los hechos de su vida vinculada con las características socioculturales del país y de la época de su recepción.

Synthesis of Imidazole Derivatives and Their Biological Activities Delia Hernández Romero, Víctor E. Torres Heredia, Oscar García-Barradas, Ma. Elizabeth Márquez López, Esmeralda Sánchez Pavón Abstract Imidazoles play an important role in medicinal chemistry, because many of its derivatives have demonstrated significant biological activity. This article is a revision of the last years, of the synthesis methods used in the preparation of imidazole derivatives which have shown biological activity as antibacterial, antiinflammatory, analgesic, antifungal, anticancer, antidepressants, including inside the biological activities of different therapeutic diseases. Full Text: PDF DOI: 10.15640/jcb.v2n2a3