Universidade Sagrado Coração

The professionalization of electronic sports (Esports) and streaming has introduced new challenges to players' physical and mental health, including chronic stress, sleep disruption and pain-related dysfunction. These factors are linked to bruxism and temporomandibular disorders (TMD), yet their prevalence and psychosomatic correlations within this community remain unknown. This study aimed to investigate the occurrence of bruxism and TMD among Esports players and streamers as well as their associations with psychosomatic and gaming-related variables. This cross-sectional study included 97 Esports players and streamers that completed validated self-report instruments screening for TMD (TMD pain-screener), bruxism, sociodemographic data, oral behaviors, sleep quality, perceived stress, anxiety, somatic symptoms, pain vigilance, and gaming/streaming habits. In addition to standard statistical tests, orthogonal partial least squares-discriminant analysis (OPLS-DA) were applied to identify group differences and multivariate associations. Nearly half of the participants screened positive for TMD (49.5%) and 78.4% reported possible bruxism. Increased daily gaming hours correlated significantly with higher perceived stress and oral parafunctions. Multivariate analyses further showed that anxiety, somatic symptoms, poor sleep and perceived stress were key factors distinguishing participants with TMD from those without, and those with combined sleep and awake bruxism from those with only awake bruxism. TMD and bruxism are highly prevalent among Esports players and streamers, with greater daily gaming exposure linked to psychosomatic stress and oral parafunctions. Digital athletes with combined sleep and awake bruxism and/or TMD experience greater psychosocial distress, indicating a subgroup that needs closer attention through early screening and targeted preventive strategies. • First study to assess bruxism and TMD prevalence and psychosocial ties in Esports. • This population is vulnerable to the development of painful TMD and bruxism. • Longer daily gaming hours were linked to higher stress and oral parafunctions.

To evaluate the reliability of the registration of occlusal contacts through intraoral scanning in comparison with those obtained with the aid of carbon paper. The occlusal registration was obtained at the beginning of the orthodontic treatment of 35 patients (23 men and 12 women), aged 15 to 30 years. All patients were scanned with iTero Element (Align Technology, CA, USA), occlusal records were also performed with carbon paper (AccuFilm - 8 μm, USA) and recorded in occlusograms. To verify the agreement between the two methods, the percentages of agreement and disagreement and kappa statistics were applied. There was poor agreement between occlusal contacts recorded by intraoral scanning and those obtained with carbon paper in most of the sample (Kappa value 0.07 to 0.20). Most contacts were registered in the posterior region. It seems that the contacts registered as intense in the iTero, correspond to the contacts with the carbon paper. The occlusal records by means of scanning and carbon paper presented poor agreement, but the association of both methods is indicated for the correct registration of the occlusion.

Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. This mixed-methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis (MS), Parkinson disease (PD), or stroke. Participants were enrolled at the Massachusetts General Hospital outpatient clinic in Boston (01/2021-08/2025) and underwent a point-of-care, low-field portable MRI (pMRI) using a 0.064 T scanner (Hyperfine) and pre- and post-scan surveys. For comparison, all participants had received a standard clinical brain MRI of at least 1.5T. Of the 130 participants (54% male, 46% female), the mean age was 60.6 years (standard deviation (SD) = 17.5). 71% reported at least one barrier to MRI care. The median interval between pMRI and standard MRI brain imaging was 48.5 days (25th, 75th percentiles: 26, 112.5). Participants rated pMRI as highly tolerable, with 93% reporting comfort scores ≥ 7 (on a 10-point scale), and 78% indicating willingness to undergo future pMRI. Mean comfort ratings were significantly higher for pMRI (8.4) compared to traditional MRI (7.5; p < 0.05), though the effect size was moderate (η2 = 0.096). No differences in tolerability or comfort were observed across disease, age, or sex groups. Common barriers to standard MRI access included transportation, cost, and scheduling, particularly among low-income or unemployed participants. Qualitative feedback emphasized the need for better physical accommodations but broadly supported the acceptability and potential uses of pMRI. These findings support the feasibility, tolerability, and high patient acceptability of pMRI.

Summary STP with plasma‐derived C1 inhibitor in patients with HAE‐nC1INH can reduce the risk of post‐procedure attacks. Efficacy in preventing attacks in patients with HAE‐FXII was higher than in those with HAE‐UNK.

ObjectivesLeukocyte platelet-rich fibrin (L-PRF) has garnered attention due to its biocompatibility, low cost, and regenerative potential. This paper presents a clinical case series demonstrating the versatility and effectiveness of L-PRF in oral and maxillofacial surgery.Patients and Methods This case series comprised six patients who underwent comprehensive clinical and imaging evaluations and were recommended for oral surgery interventions using L-PRF. The cases include venipuncture, L-PRF preparation, and its clinical applications.ResultsIn Patient 1, an oroantral communication was closed using an L-PRF membrane and vestibular flap, achieving satisfactory soft-tissue healing. Patient 2 underwent a maxillary sinus lift with bone graft material and L-PRF membranes (replacing collagen membranes) to reduce cost and enhance bone regeneration. In Patients 3 to 5 (all systemically compromised), post-extraction placement of an L-PRF plug and membranes prevented complications and preserved the alveolar ridge for future rehabilitation. Finally, Patients 6 and 7, both with recurrent pericoronitis of partially erupted lower third molars, received extractions followed by L-PRF plug and membrane placement, with uneventful healing in all cases. The findings reinforce the growing body of evidence supporting the benefits of L-PRF in oral and maxillofacial surgery.ConclusionL-PRF represents a promising, biocompatible tool in clinical practice, offering significant advantages for patient recovery and surgical outcomes.

Pain following endodontic treatment is a common complication potentially linked with genetic polymorphisms that modulate pain biomarkers. Hence, this study aimed to explore the association between pain experienced after endodontic treatment and genetic polymorphisms in the genes encoding inducible nitric oxide synthase (NOS2), and suppressor of cytokine signaling (SOCS1). The study involved 108 participants with single-rooted teeth, single canals, and necrotic pulp related to asymptomatic apical periodontitis. All endodontic treatments were executed in a single session. Pain and tenderness levels were measured using a visual analog scale (VAS) on the 1st, 2nd, 3rd, 4th, 5th, 6th, 7th, 14th, and 30th day post-treatment. Genomic deoxyribonucleic acid (DNA) was extracted from saliva cells and the genetic polymorphisms rs2779249, rs2297518, rs243327 and rs33977706 were genotyped using real-time polymerase chain reaction. Genotype distribution was assessed using univariate and multivariate Poisson regressions through generalized estimating equations (GEE) and categorized based on the presence or absence of pain and tenderness, and the significance threshold was set at p < 0.05. The genetic polymorphism rs2297518 in the NOS2 gene was associated with pain in the recessive model (p = 0.019) and to tenderness in both the codominant (p = 0.008) and recessive (p < 0.001) models. The genetic polymorphisms rs2779249 in NOS2 and rs243327 and rs33977706 in SOCS1 showed no association with pain or tenderness (p > 0.05). In conclusion, the genetic polymorphism rs2297518 in the NOS2 gene was associated with pain after root canal treatment. These findings contribute to a better understanding of the genetic factors influencing postoperative pain in endodontics, which may help in developing personalized pain management strategies and improving patient care.

Cannabidiol (CBD) is a non-psychotropic compound found in plants of the Cannabis genus, extensively studied for its therapeutic potential. Research has shown that CBD possesses anti-inflammatory, antioxidant, and regenerative properties, and may contribute to the recovery of neural and bone tissues. In light of the aging population and the resulting rise in neurodegenerative and osteodegenerative conditions, exploring novel therapeutic strategies that promote cellular regeneration is increasingly important. This review aims to compile and critically analyze key studies published in recent decades regarding the effects of CBD on the regeneration of the central and peripheral nervous systems, as well as bone tissue. Findings from in vivo studies indicate that CBD can attenuate inflammatory responses, inhibit oxidative stress, and modulate cellular pathways involved in tissue repair, thereby supporting neuronal and bone regeneration. Moreover, evidence suggests that CBD may protect cells from structural damage, enhancing the functional recovery of affected tissues. Despite scientific advances highlighting cannabidiol as a promising agent for bone and nerve regeneration, its therapeutic application still faces significant limitations. The primary challenge lies in the lack of robust clinical trials in humans, as most existing evidence is derived from in vitro and in vivo studies, making it difficult to confirm its efficacy and safety in clinical contexts. Additionally, CBD’s low bioavailability—due to first-pass hepatic metabolism—hinders dose standardization and reduces the predictability of therapeutic outcomes. Compounding these issues are regulatory constraints and the persistent social stigma surrounding cannabis-derived compounds, which further impede their integration and acceptance in regenerative medicine. Therefore, future research is essential to validate the therapeutic benefits of CBD and to establish its clinical applicability in treating neurological and bone disorders.

<h2>ABSTRACT</h2><h3>Objectives</h3> The primary aim of this study was to evaluate the accuracy and precision of a deep learning artificial intelligence (AI) model in reconstructing 3D facial geometry from a single 2D photograph. The study specifically measured the coordinate differences of human-placed facial landmarks on the AI-generated models against those placed on 3D models from a gold-standard scanner (Bellus 3D). Secondary objectives included identifying dimensional variations (X, Y, Z) and systematic biases in the AI reconstructions <h3>Methods</h3> This was a retrospective comparative study using a sample of 47 anonymized patient records from the University of the Pacific database. For each patient, a 3D facial model was generated from a 2D photograph using the 3DDFA-V2 deep learning model. These AI-generated models were compared to reference models captured on the same day using a Bellus 3D Scanner. Two trained observers identified a set of facial landmarks on both the AI-generated and Bellus 3D models. The coordinate data were normalized using Procrustes analysis to compare shape and landmark position independent of scale and orientation. The differences in landmark coordinates between the two model types were then statistically analyzed. <h3>Results</h3> The analysis revealed that human landmark identification on the AI-generated 3D models reconstructed from 2D photos showed consistently lower variability compared to the gold-standard scans, suggesting that those models may lead to more repeatable measurements. The greatest overall deviations (Euclidean error) were found in landmarks associated with the lateral and inferior borders of the face, such as Right Gonion (RGo), Trichion (Tr), and Left Gonion (LGo). Quantitatively, the mean Procrustes-normalized error across all landmarks was 0.19 ± 0.08 units (range: 0.08–0.45), corresponding approximately to 0.2 mm of proportional deviation when referenced to the 1:1 scale Bellus3D models. While the AI-generated model demonstrated high fidelity, systematic biases were observed mainly as inferior displacements of key landmarks, including Menton (–0.35 units) and Pogonion (–0.30 units), reflecting a consistent downward shift in AI-based reconstruction <h3>Conclusions</h3> The 3DDFA-V2 deep learning application demonstrated in this study is a promising low-cost tool for generating 3D facial models from 2D photographs with a high degree of precision in landmark placement. While the AI models facilitated more repeatable landmarking, they also exhibited some systematic biases. These findings have clinical implications for the use AI-generated 3D models in diagnosis and treatment planning, highlighting areas where further refinement of the AI algorithm is needed.

Background. The accurate fit between the dental implant and the prosthetic abutment is crucial for the stability of the entire prosthetic-implant system, providing a better distribution of the occlusal load to the surrounding bone. To improve stress distribution between the implant and bone, various types of internal connection implants have been introduced. However, few studies are available on the biomechanical behavior of these connections. This study investigated the stress distribution in screwed implant-supported prosthesis with different implant‒abutment connections using a photoelastic analysis. Methods. Eight photoelastic models were fabricated in PL-2 resin and divided according to the different types of internal connections: Morse taper (MT), internal Morse hexagon (IMH), Morse taper hexagon (MTH), and frictional Morse taper (FMT) implants (3.75×11.5 mm), and the number of crowns (single and 3-unit pieces). Models were positioned in a circular polariscope, and 100-N axial and oblique (45º) loads were applied to the occlusal surface of the crowns using a universal testing machine. The stresses were photographically recorded and qualitatively analyzed using Adobe Photoshop software. Results. Under axial loading, the number and distribution of high-intensity fringes did not differ among groups for both crown types (single and splinted 3-element). Low stress values were noted at the implant apex. The oblique loading increased the number of fringes for all groups. In conclusion, the internal connection tested in this study did not affect the number and distribution of stress.Conclusion. The different types of internal connections provided better stability for the implant‒prosthesis set, which improved stress distribution when the prosthetic pillar was loaded, with the Morse cone friction system showing less stress. Oblique loading resulted in a higher stress concentration than axial loading.