Universitas Dr. Soetomo

The aim of this article is to analyze the role of digital marketing strategies in enhancing brand awareness and consumer loyalty on e-commerce platforms in Indonesia. This article employs a qualitative literature review method by examining various references from leading international journals published in the last five years. The findings of the research indicate that digital marketing strategies, including content personalization, the use of social media, and consumer data, have a significant impact on improving brand awareness. Furthermore, brand awareness plays a crucial role as an important mediator between digital marketing strategies and consumer loyalty. The discussion reveals that consumer loyalty is influenced not only by brand awareness but also by adequate digital experiences and the quality of service provided by the platform. In conclusion, to enhance consumer loyalty, e-commerce platforms in Indonesia need to design comprehensive digital marketing strategies that focus not only on brand recognition but also on delivering consistent and satisfying user experiences.

Acute limb ischemia (ALI) is a vascular emergency requiring prompt revascularization to prevent limb loss and death. Endovascular thrombectomy (ET) and catheter-directed thrombolysis (CDT) are the most commonly used strategies. Despite their increasing use, comparative effectiveness and safety remain unclear. This study aims to compare the clinical outcomes between ET and CDT in patients with ALI. This systematic review and meta-analysis followed PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analysis) 2020 guidelines and was registered in PROSPERO (CRD42024590036). A comprehensive literature search in scientific databases was conducted up to December 2024. Studies comparing ET and CDT in adult patients with ALI were included. Data were pooled using random- or fixed-effects models depending on heterogeneity. Sensitivity and publication bias analyses were performed. Five retrospective studies with 495 patients (ET: 256; CDT: 206) were analyzed. No significant differences were observed between groups in terms of technical success (risk ratio [RR]=0.72, p=0.40), clinical success (RR=1.01, p=0.78), or limb salvage (RR=1.00, p=0.94). ET was associated with a longer procedure duration (mean difference [MD]=57.80 minutes, p=0.03) but shorter hospital stays (MD=-1.86 days, p=0.04). Major complications were lower in the ET group, the difference was not statistically significant (RR=0.63, p=0.15). Cost reporting was heterogeneous, suggesting a potential trade-off in which ET has higher upfront costs but shorter hospitalization. ET and CDT demonstrated comparable effectiveness in revascularization outcomes for ALI. ET may offer added benefits by reducing complication rates and shortening recovery time. The choice between interventions should take patient-specific factors into account.Clinical ImpactThis study supports the use of endovascular thrombectomy (ET) as an effective alternative to catheter-directed thrombolysis (CDT) due to its favorable safety profile, demonstrated by lower rates of major complications and shorter hospital stays. ET may be particularly suitable in patients with a high bleeding risk. However, individual patient anatomy and comorbidities remain critical determinants in treatment selection. Institutional factors and cost-effectiveness considerations also play important roles in determining the choice of intervention. Overall, both techniques ET and CDT are effective revascularization strategies for restoring arterial perfusion in acute limb ischemia.

Penelitian ini bertujuan untuk menganalisis pengaruh content marketing dan adopsi e-commerce terhadap kinerja pemasaran usaha mikro, kecil, dan menengah (UMKM) dengan digital customer engagement sebagai variabel mediasi menggunakan pendekatan PLS-SEM. Data dikumpulkan melalui survei terhadap 160 pelaku UMKM di Blitar dan dianalisis menggunakan SmartPLS 4. Hasil penelitian menunjukkan bahwa content marketing dan adopsi e-commerce berpengaruh positif dan signifikan terhadap digital customer engagement, namun keduanya tidak berpengaruh secara langsung terhadap kinerja pemasaran. Digital customer engagement terbukti memiliki pengaruh yang kuat terhadap kinerja pemasaran serta memediasi secara penuh hubungan antara content marketing, adopsi e-commerce, dan kinerja pemasaran. Temuan ini menegaskan bahwa keberhasilan pemasaran digital UMKM di era digital sangat bergantung pada kemampuan pelaku usaha dalam membangun dan mendorong keterlibatan pelanggan secara berkelanjutan guna meningkatkan daya saing bisnis dan keberlanjutan usaha dalam lingkungan ekonomi digital yang kompetitif.

Regional differences in the gut microbiota and CRC incidence and mortality rates are well-documented. However, studies on the microbiota associated with CRC in Indonesia remain scarce. This study aimed to chracterize the gut microbiota profile of CRC in Indonesia. We collected stool samples from 14 patients with CRC (CRC), 19 patients with non-CRC bowel diseases (non-CRC), and 16 healthy controls (HC). The gut microbiota profiles across the three groups were analyzed using 16 S rRNA gene amplicon sequencing. Data analysis was performed using several software packages: QIIME2, ANCOM-BC2, and PICRUSt2. In comparison to the non-CRC and HC groups, patients with CRC demonstrated significant differences in both alpha and beta diversity. The CRC group had lower evenness and richness than the HC group. Firmicutes and Bacteroidota were identified as the predominant phyla across all groups. The differential abundance analysis identified four beneficial genera that were substantially reduced in Indonesian CRC patients: Roseburia, Dialister, Agathobacter, and Muribaculaceae. No genera were found to be significantly enriched in CRC. Functional prediction analysis revealed multiple pathways such as mTOR, mRNA surveillance, basal transcription factors, phagosome, and proteasome, were reduced in CRC. Conversely, CRC demonstrated a significant upregulation of pathways related to lipid metabolism and the biosynthesis of flavonoids, stilbenoids, diarylheptanoids, and gingerols. Our study revealed distinct gut microbiota profiles in Indonesian CRC patients, highlighting the significance of decreased abundance of certain beneficial taxa.

Purpose: This study examines how influencer marketing and customer engagement enhance loyalty and advocacy, with perceived value as a key mediator, to clarify the mechanisms behind these effects in a competitive digital landscape. Methodology: Using a quantitative survey of active online consumers, this study applied Partial Least Squares Structural Equation Modeling (PLS-SEM) to examine the direct effects of influencer-based advertising and customer engagement on perceived value, loyalty, and advocacy, as well as the mediating role of perceived value. Results: The findings demonstrate that both influencer-based advertising (? = 0.452, p < 0.001) and customer engagement (? = 0.384, p < 0.001) significantly boost perceived value. In turn, perceived value significantly mediates the impact of these antecedents on customer loyalty and advocacy, highlighting its critical intermediary role. Notably, while influencer marketing and engagement exert strong direct effects on loyalty, only customer engagement, and not influencer marketing, directly influences advocacy. Conclusions: Influencer-based advertising and customer engagement increase perceived value, strengthening loyalty and advocacy; however, only customer engagement directly influences advocacy. Limitations: This study's cross-sectional methodology records data at only one particular moment, making it more difficult to identify changes over time and to draw conclusions about causal linkages. Contributions: This research contributes to marketing theory and practice by pinpointing perceived value as the essential conduit linking marketing stimuli to lasting customer behaviors. It offers empirical evidence that both influencer strategies and engagement foster loyalty and advocacy principally by enhancing perceived value.

Abstract Stroke is marked by sudden symptoms leading to neurological function loss due to brain bleeding or impaired blood supply. Intracerebral hemorrhage (ICH) is the most common stroke subtype, involving bleeding in the brain parenchyma. A craniotomy is performed to evacuate the hematoma, reducing pressure and potentially restoring neurological functions such as consciousness, motor skills, and blood pressure. This study aims to compare preoperative and postoperative neurological deficits in ICH stroke patients who underwent craniotomy. An analytical observational study with a cross-sectional design was conducted using purposive sampling in patients diagnosed with ICH stroke who underwent craniotomy in a tertiary hospital. Data were analyzed using the McNemar and Wilcoxon tests. A p < 0.05 was considered statistically significant. Of the 162 patients with ICH stroke, most were male (56.8%) and aged 45 to 54 years (32.1%). Facial nerve paresis significantly improved after surgery (p = 0.006). All patients were seizure-free postoperatively. Motor function also showed significant improvement (p = 0.001). Blood pressure decreased significantly after surgery (p < 0.001) and Glasgow Coma Scale (GCS) scores improved (p = 0.005). There is a significant improvement in neurological deficits between the preoperative and postoperative stages in ICH stroke patients. Craniotomy significantly improves neurological outcomes, including facial nerve paresis, motor function, seizures, blood pressure control, and GCS scores in patients with ICH stroke.

The utilization of Bouke Ami fishing gear in Indonesian waters, particularly in PPN Muara Angke, plays a significant role in managing fishery resources and increasing production. This gear is commonly used by fishermen to catch pelagic fish such as mackerel, tuna, and squid. However, the environmental friendliness of Bouke Ami fishing gear is crucial for sustainable fisheries management. While effective in catching fish, this fishing gear can negatively impact the marine ecosystem, including damage to coral reefs and the capture of juvenile fish, which affects their growth. This research aims to assess the level of environmental friendliness of the Bouke Ami fishing gear used in PPN Muara Angke. Conducted from November 2025 to January 2026, the study employed a descriptive method, using interviews and questionnaires with Bouke Ami fishermen. The findings are expected to contribute to the literature on sustainable fisheries and highlight the importance of using environmentally friendly fishing gear, in line with the Code of Conduct for Responsible Fisheries.

This research attempts to investigate the impact of Internal Communication Transparency and Top Management Support on Employee Performance at FAST Coffee & Bikewash, both partially and simultaneously, and to identify the most dominant variable influencing employee performance. A quantitative methodology was used in this study, utilizing multiple linear regression analysis. The population consisted of all employees and management members, with a total sample of 38 total sampling was used to pick the respondents. Instrument testing, traditional assumption testing, and hypothesis testing with the t-test and F-test were used to examine the data. The results indicate that partially, Internal Communication Transparency and Top Management Support has a positive and significant effect on Employee Performance. Simultaneously, both variables significantly affect Employee Performance

This study aimed to assess the biomechanical performance, cellular integration, and extracellular matrix (ECM) remodelling of mesenchymal stem cell (MSC)–seeded decellularized HUV scaffolds as candidates for tissue-engineered vascular grafts (TEVG) Decellularized HUVs were prepared using an optimized sodium dodecyl sulphate (SDS) protocol and subsequently seeded with human MSCs characterized by a CD90⁺/CD73⁺/CD105⁺/CD45⁻ phenotype. Four experimental groups were evaluated: non-decellularized control, decellularized control, MSC-seeded for 7 days, and MSC-seeded for 14 days. Biomechanical parameters (tensile strength, Young’s modulus, and suture-holding capacity) and immunohistochemical markers (CD105, CD45, collagen type I, collagen type IV, and elastin) were analyzed. Surface analysis was examined by scanning electron microscopy (SEM). MSC seeding preserved tensile strength and elasticity across all groups, confirming mechanical stability after culture. CD105 expression was significantly upregulated in the 14 day seeding group compared with controls (p = 0.048), while CD45 expression remained minimal across all groups, confirming MSC phenotype retention. Among ECM proteins, collagen type I increased significantly at 14 days (p = 0.014), whereas collagen type IV and elastin showed non-significant trends toward higher expression. SEM revealed smooth inner and porous outer scaffold layers conducive to cell adhesion. MSC seeding on decellularized HUV scaffolds supports early cellular integration and collagen remodelling without compromising mechanical strength. The increased CD105 and collagen type I expression after 14 days suggests the onset of active matrix synthesis, whereas unchanged elastin levels highlight the need for longer-term culture or dynamic conditioning. These findings demonstrate the potential of MSC-seeded decellularized HUV scaffolds as a feasible platform for small-diameter TEVG.