University Vascular Associates

El espacio comprendido en la Reserva de la Biosfera de los Ancares Leoneses abarca cuatro municipios y una extensión total de 57.000 hectáreas, en su mayor parte de montaña media y alta en la transición bioclimática entre el área atlántica y el área mediterránea. Estas montañas llevan más de un siglo perdiendo población, estando en el momento actual en el límite del vaciamiento total. Se analiza el proceso de declive demográfico y las características actuales de envejecimiento extremo de la población. El vaciamiento ha implicado un abandono de aprovechamientos agrícolas y ganaderos, lo cual ha desencadenado un proceso de asilvestramiento del territorio, manifestado en cambios drásticos del paisaje a través de la regeneración de la vegetación natural.

This working paper presents a comparative study on the health and safety conditions workers face in two sectors (construction and PHS/domestic work) and concerning the extent to which workers in these sectors can effectively exercise their social rights concerning OSH. Also, it examines how the main EU acquis on occupational health and safety at work has been transposed and applied and what its impact has been in terms of available power resources for workers in the two sectors. It explains the way the respective Directives foster effective social rights for workers through legislation and collective agreements. The study includes seven EU member states, namely, Denmark, France, the Netherlands, Spain, Germany, Poland, and Ireland. We combine legal analysis with document analysis, semi-structured interviews, and descriptive statistics from national sources. According to our research, in general terms, the national transposing legislation of the OSH is in conformity with the studied EU OSH Directives. Our research also shows that, in many of the country cases, compliance with the OSH Directives minimum requirements is better in large establishments than in SMEs. However, there are some cases where the national legislation goes beyond the requirements of the EU framework directive. For example, in certain EU Member States domestic workers are included in the definition of ‘worker’ when transposing the Framework Directive, setting a broader personal scope of application than the Directive. But still, the workers in the two sectors face many health and safety problems and lack sufficient power resources to deal with them. Based on our analysis we present a series of policy recommendations that can help to improve this situation and strengthen the power resources of workers in the two sectors.

Abstract Introduction Major adverse cardiovascular events occur most commonly in the morning compared to other times of the day or night. Evaluation of coronary microvascular reserve perfusion can be used to reflect the anatomic and functional status of the coronary vascular system, both of which contribute to major adverse cardiovascular events. Prior work suggests that coronary microvascular function is attenuated in the morning, but whether the circadian system contributes to this attenuation is unknown. Methods To determine if the circadian system drives the morning attenuation in coronary microvascular function, we studied 13 healthy participants (8 females, 5 males; 42+/-13 years [mean+/-SD]) in a 5-day forced desynchrony protocol in dim light, where all behaviors and measurements were distributed across the 24-hour cycle. Coronary microvascular function was evaluated by vasodilator myocardial contrast echocardiography, sequentially 16 hours apart, corresponding to each participant’s morning, evening and night. We analyzed time-intensity data to calculate microvascular flux rate (beta) at rest and during hyperemia for each measurement. Circadian phases were calculated based on individual dim-light melatonin onsets. We grouped data into three ~8-hour circadian bins corresponding to each participant’s morning, evening and night. Mixed model analyses were used to determine if there were significant differences between data collected in the circadian morning compared to the other times while controlling for the measurement schedule and between-subject variability. Results There were no significant time-dependent differences in echocardiographic indices of ventricular function, including stroke volume, cardiac output, or myocardial work. Contrary to our hypothesis, hyperemic perfusion was lowest in the evening rather than the morning (2.49 /s vs. 2.82 /s, p=0.042) but not different between morning and night (also 2.82 /s, p=0.96). Conclusion In healthy people, there is no circadian-system-driven morning attenuation in coronary microvascular function: indeed, the circadian system facilitates coronary vascular flow in the morning, possibly to accommodate the anticipated behaviorally driven increases in myocardial demand after awakening. Support (if any) NIH KL2TR002370, R01HL163232, R35HL155681, R01HL140577, R01HL130046, R01HL078610, R01HL156948, K01HL146992, K01HL151745, ULTR00128, Sleep Research Society Foundation, Oregon Institute of Occupational Health Sciences.

TBA

Exploramos uma discussão moral em sala de aula, empregando a teoria filosófica de Albert Camus, notável por sua trajetória de destaque mesmo sendo de origem humilde e com escassa base de estudos. A discussão abrange temas como suicídio, angústia, existência e revolta, visando proporcionar uma compreensão profunda da realidade absurda. O estudo busca compreender a dignidade do exercício docente, ancorando-se em romances camusianos, especialmente "O primeiro homem". A importância da escola e do professor na vida de Camus é analisada, destacando a interseção entre sua vida, filosofia e a figura do professor como uma luz no fim do túnel até mesmo para Albert Camus, o qual faz questão de retratar seu agradecimento por ocasião do Nobel de 1957.

We describe research towards leveraging deep learning on graph representations of the injector beamline at the Continuous Electron Beam Accelerator Facility (CEBAF) in order to create a tool for improving the efficiency of beam tuning tasks. Specifically, we use graphs to represent the injector beamline at any arbitrary date and time and invoke a graph neural network to extract a low-dimensional, informative representation that can be visualized in two-dimensions. By analyzing years of operational data from the CEBAF archiver, good and bad regions of parameter space can be identified. The goal is to exercise this framework as a real-time tool to aid beam tuning, which represents the dominant source of machine downtime.

Files generated for the analyses in Souza et al.: "Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data". The code that generated these files are in the repository https://github.com/vladimirsouza/lrRNAseqVariantCalling. The file names are associated with their respective file path defined in the code, where '/' were replaced by '-'. For file descriptions, see file_descriptions.csv file.

Files generated for the analyses in Souza et al.: "Transformation of alignment files improves performance of variant callers for long-read RNA sequencing data". The code that generated these files are in the repository https://github.com/vladimirsouza/lrRNAseqVariantCalling. The file names are associated with their respective file path defined in the code, where '/' were replaced by '-'. For file descriptions, see file_descriptions.csv file.

La participación de la víctima en la fase de ejecución del proceso penal en nuestro ordenamiento es un hecho novedoso que, más allá de la reparación civil, arranca del Estatuto de la víctima en año 2015, el cual introduce la Justicia Restaurativa en ese momento procesal. Este instrumento puede ser una importante alternativa o complemento a la Justicia tradicional en aras de lograr una mejor satisfacción de los intereses de la victima. Siendo este el objetivo, se viene desarrollando desde el año 2019 una experiencia en el CIS “Máximo Carrera” de Valladolid en la cual se trabaja con liberados condicionales, penados clasificados en tercer grado y condenados a la pena de trabajos en beneficio de la comunidad, con el objetivo de elaborar un protocolo de actuación extensible a otros centros. The participation of the victim in the execution phase of the criminal process in our legal order is a novel fact that, beyond civil reparation, starts from the Statute of the victim in 2015, and introduces Restorative Justice at that procedural moment. This instrument may become an important alternative or complement to traditional Justice in order to achieve a better satisfaction of the interests of the victim. A Program dealing with conditional parole inmates, convicts classified in third degree and sentenced to comunity services has been developed in the CIS “Máximo Carrera” of Valladolid since 2019, with the aim of drawing up an action protocol that may be extended to other prisons.