University of Franche-Comté

Trastuzumab used for the treatment of patients with HER2-positive breast cancer induces cardiotoxicity. The NRG1/HER pathway plays a central role in human cardiovascular physiology; however, the link between exercise, NRG1, and cardiotoxicity is unclear. Patients were randomized to receive adjuvant trastuzumab in combination with a training program (TG) or trastuzumab alone (CG). The aim of this study was to assess the effect of a 12-week supervised exercise training on the circulating level of NRG1. Secondary objectives were to assess the correlation between NRG1 level and cardiotoxicity. 89 patients were randomized (TG; n = 46; CG; n = 43), 76 have a NRG1 concentration available at baseline. After the exercise program, plasma levels of NRG1 decreased significantly in the TG (mean difference -0.20ng/ml; 95% CI, -0.32, - 0.07) whereas they remained stable in the CG (mean difference - 0.05ng/ml; 95% CI, - 0.20, 0.10). Notably, baseline NRG1 concentrations were higher in the TG group. However, no correlation between NRG1 changes and either cardiorespiratory fitness (V̇O2 max) and left ventricular ejection fraction (LVEF) was observed (R = 0.087, p = 0.53; R = -0.157, p = 0.26; and R = -0.131, p = 0.33, respectively). A 12-week interval training program significantly decreased NRG1 concentration in HER2-positive patients with breast cancer treated with adjuvant trastuzumab therapy, despite the trained group presenting higher baseline NRG1 values compared to the control group. In addition, this change was neither associated with V̇O2 max nor with LVEF. This trial was registered with ClinicalTrials.gov under the number NCT02433067.

The present study aimed to report the early and late clinical outcomes of patients who underwent surgical repair for acute type A aortic dissection requiring concomitant coronary artery bypass grafting (CABG), and to explore potential risk factors associated with the need for this additional procedure. Data were retrieved from the multicenter European Registry of Type A Aortic Dissection (ERTAAD). Bootstrapped least absolute shrinkage and selection operator logistic regression and multilevel multivariate logistic regression were performed for variable selection to identify predictors of hospital death, and logistic regression was used for the prediction of CABG. A total of 292 (8.04%) of 3633 patients required additional CABG. The in-hospital mortality rate was 33% for patients undergoing CABG vs 16% of non-CABG recipients (P < .001; odds ratio [OR], 2.52; 95% CI, 1.93-3.35). Dissection of the aortic root involving the right coronary cusp (P < .001; OR, 7.83; 95% CI, 5.55-11.0), a tear in the aortic root (P = .002; OR, 2.08; 95% CI, 1.29-3.32), mitral valve insufficiency (P = .034; OR, 1.33; 95% CI, 1.01-1.71), and a genetic syndrome (P < .001; OR, 3.23; 95% CI, 1.66-5.99) independently predicted the need for CABG. The need for additional CABG is not a rare occurrence during repair of type A aortic dissection and is associated with an increased mortality risk. Intimal tear localization and right coronary sinus dissection should be carefully examined in the preoperative image evaluation to stratify the risk of revascularization and plan the most appropriate approach.

We performed deep next-generation sequencing using a 55-gene panel in 590 affected tissue samples from 549 patients referred for various cutaneous birthmarks, mostly vascular anomalies. We confirm that double variants in tissue from vascular anomalies are a rare event. We report the clinical features of eight patients with double variants and discuss their clinical significance and impact on treatment options.

The authors declare no conflicts of interest.

Abstract This article aims to analyze three fundamental phases of motherhood: pregnancy, childbirth, and the postpartum period. Special emphasis is placed on the work that the maternal psychic apparatus must undertake in managing the demands arising from the reunion with archaic contents from their past during pregnancy, in the process of childbirth, and in the exercise of mothering when engaging with the baby. Our goal is to foster a thoughtful theoretical discussion, drawing from psychoanalysis, about the subjective journey of motherhood, with its intricate complexities, connections, and disconnections. This exploration considers that the skills required for baby care involve: ability of reverie, transmission of psychological aspects across generations, and the history of interpersonal exchanges between the mother and her own caregivers.

This study reports the serendipitous discovery of intermolecular anionic mixed‐valence (MV) and π‐dimer species in ortho‐pentannulated BisAzaCoroneneDiimides (BACDs) during their electrochemical reduction in a non‐aqueous solvent. A library of nitrogen‐containing extended PDIs was synthesized via an aza‐benzannulation reaction followed by a Pd‐catalysed ortho‐pentannulation reaction. Ortho‐pentannulated BACDs revealed strong aggregation abilities in solution. Concentration‐dependent UV/Vis absorption spectra, variable temperature 1H NMR experiments, and atomic force microscopy coupled to molecular dynamics support their self‐assembly into columnar aggregates. Cyclic voltammetry experiments in dichloromethane reveal prominent splitting of the first reduction wave, attributed to the formation of unprecedented intermolecular anionic MV and π‐dimers in organic solvent. These species were thoroughly characterized by real‐time spectroelectrochemistry, electrochemical simulations and theoretical calculations. Remarkably, this work underscores the tuneable nature of AzaBenzannulatedPerylene Diimides (AzaBPDIs) and BACDs, emphasizing their potential as a promising scaffold for designing supramolecular materials with long‐range radical anion delocalization. The observation of this phenomenon provides insights into the fundamental behaviour of supramolecular organic semiconductors, thereby paving the way for the development of novel electronic devices and electron‐deficient materials.

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Abstract Organic amendments are commonly applied singularly to soils to improve physical, biological and chemical properties, but their combination may be even more advantageous than when applied alone. In this study manure was applied singularly and in combination with biochar (90:10 and 50:50 ratios) to a drought prone agricultural Regosol in a field evaluation. Samples were collected twice a year for 2 years and subjected to testing for moisture retention, nutrient status and microbial activity whilst weed growth was monitored by drone. Substantial seasonal variability in all parameters measured was observed, though all amendments increased actual soil moisture content between 18 and 41% initially; without the addition of biochar (i.e., manure alone) this reverted back to reduced moisture content towards the second year of sampling. None of the tested amendment combinations significantly affected soil‐saturated hydraulic conductivity. Cation exchange capacity decreased as a result of manure addition alone, the addition of 10% biochar and 50% biochar increased this significantly (23%–54% increase). Though microbial biomass and enzyme soil health indicators showed no decisive changes as a result of amendment application, and plant biomass was variable by ground sampling, drone imagery proved that plant heights and health were generally increased as a result of biochar addition to manure, compared with manured soil alone. In summary, despite much field seasonal variability limiting the interpretation of the data, this study nonetheless demonstrates a useful maintenance of improved soil moisture achieved by adding biochar together with manure to a drought‐prone soil agricultural soil.