University of Technology and Management

Introduction. The neuroactive insecticide imidacloprid, a member of the neonicotinoid class, is widely used worldwide to control various insect pests. Its high solubility leads to its entry into surface and groundwater, posing a significant risk to aquatic life.The aim of this study was to evaluate the acute and subchronic toxicity of imidacloprid on Danio rerio, including determining the LC50 and investigating the effects of varying insecticide concentrations on hematological parameters, genotoxicity, and histopathology of the gills, liver, trunk kidney, and middle intestine.Material and methods. The study used standard methods for determining the sublethal concentration in aquatic toxicology, as well as examining the leukocyte formula, genotoxicity, and histological preparations of D. rerio.Results. The 96-hour LC50 (LC5096) was determined to be 85.3 mg/L, with a 95% confidence interval (CI) of 76.16-96.98 mg/L. Hematological and histopathological changes were investigated for subchronic toxicity across a concentration range of 4 to 76 mg/L. Imidacloprid exposure resulted in a concentration-dependent decrease in erythrocyte counts, an increase in leukocyte counts, lymphopenia, and elevated numbers of monocytes, neutrophils, and basophils. An increased number of erythrocytes with nuclear abnormalities (deformed nuclei, 2.77‰; and fragmented nuclei, 2.85‰) was observed at concentrations of 38 and 76 mg/L. Histological changes were observed in the gills (basal epithelial atrophy and respiratory epithelial detachment), liver (sinusoidal capillary dilation and hepatocyte vacuolization), and kidneys (capillary dilation and tubular epithelial necrosis). The most prevalent histopathological finding was impaired circulation. In the middle intestine, an increased number of goblet cells and intraepithelial lymphocytes was observed.Limitations. The toxic effect of imidacloprid was assessed within the acute experiment. Additional experiments with longer duration and on other laboratory species would allow to reveal in more detail the mechanisms of toxic effect and related histopathological in disorders.Conclusion. The findings demonstrate the systemic toxicity of imidacloprid at concentrations exceeding 19 mg/L in Danio rerio organs and tissues.Compliance with ethical standards. The study was approved by the Commission on Bioethics of K.G. Razumovsky Moscow State University of Technology and Management, carried out in accordance with the European Convention for the Protection of Vertebrate Animals used for Experimental or other Scientific Purposes (ETS No. 123), Directive of the European Parliament and the Council of the European Union 2010/63/EU of September 22, 2010 on the protection of animals used for scientific purposes.Authors’ contribution. All co-authors made an equal contribution to the research and preparation of the article for publication.Conflict of interests. The authors declare no apparent and potential conflicts of interest in relation to the publication of this article.Funding. This work was supported by the Russian Science Foundation (project No. 23-16-00123).Received: March 1, 2025 / Revised: April 30, 2025 / Accepted: November 25, 2025 / Published: January 15, 2026

Background: Fear and Stigma associated with STDs are considered as an important barrier to STI/RTI prevention and implementation of intervention. This study explores the barriers to STI testing in Meghalaya from the perspective of spouses and other key informants. Materials and Methods: A descriptive cross sectional research design was used where quantitative and qualitative approach was adopted. Total three districts, namely East Khasi Hills, East Jaintia Hills and West Jaintia Hills in Meghalaya are purposely taken since they have the highest number of notified spouses’ low turnout. Total sample size was 118 spouses of clients attending DSRCs. Data was analysed using SPSS and Thematic analysis. Results: Of 89 (75%) notified spouses of clients attending DSRCs, only 3 (3%) did visited the DSRCs for testing, while 86 (97%) did not visited even after being notified. Among those not visited the DSRCs (n=86), 19% (n=16) were spouses of ANC clients and 81% (n=70) were spouses of general clients. The main barriers for not visiting the DSRC were due to unavailability of time (19%), stigma (17%) and fear of judgment if seen going for STI testing (16%). Conclusion: Encouraging legislative and policy frameworks sensitive to social need is vital. Promoting community sensitisation campaign keeping in mind cultural sensitivity will improve testing uptake. Keywords: STI/RTI, DSRCs, Barriers, Notified spouses for STI testing

The Indian Institute of Science (IISc), Bengaluru ranked as India’s top higher education institution under the 2024 National Institutional Ranking Framework (NIRF)-demonstrates academic and research excellence. However, the NIRF does not assess financial strategy, an essential component of long-term institutional sustainability. This study addresses that gap by analyzing IISc’s financial performance over a ten-year period (2014–2023). The analysis utilizes audited financial statements and employs trend analysis, compound annual growth rates (CAGR), financial ratio assessments, and income–expenditure composition breakdowns. The evaluation covers six key financial dimensions: revenue growth, expenditure management, net operating performance, capital investment, liquidity, and income diversification. The findings reveal a pattern of steady revenue growth, sustained capital investment, and consistent operating surpluses. Despite these strengths, IISc remains significantly dependent on government funding. Self-generated income has shown only modest improvement, highlighting a potential vulnerability in the face of shifting policy or funding environments. While IISc demonstrates strong financial management in several areas, its high dependency on external grants underscores the need for greater diversification of income sources. This study contributes to a more comprehensive understanding of financial performance in top-tier Indian universities and provides valuable insights for policymakers and administrators seeking to ensure long-term financial resilience alongside academic excellence.

The production of a new generation of food products with pre-established quality requirements is one of the priority areas of development of the modern food industry. It is especially important to note the need for a more complete use of socially significant food products for these purposes, which also includes white sugar. Crystalline white sugar is not only an energy-important component of nutrition, but also a raw material for a number of food industry sectors. These include, for example, confectionery production, where the annual demand for it is about 1 mln tons. Imparting new nutritional properties to sugar will expand the range of products based on it. The use of iodine may be relevant in this area, since the problem of iodine deficiency in Russia still exists and has not lost its relevance. However, the implementation of such an approach is associated with technological features, including the creation of iodized products. Expanding ideas on how to solve this problem has required appropriate analysis and substantiated research for a deeper understanding of it. Moreover, special attention has been paid to the mechanism of iodine encapsulation when creating new sugar-containing products on its basis. Preliminary approaches to this problem have shown the possibility of using starch production products – cyclodextrins (CD) – for this purpose. Therefore, this paper not only examines their main properties and features, but also attempts to understand the mechanism of complex formation of CD with iodine. The results obtained have shown the prospects for using β-CD in the food industry to expand the range of new sugar-containing products and, in particular, their importance in solving the problem of iodine deficiency.

Aim. To form an idea of what tactical experience the compilers of such a source on the history of the Russian border service as the "Boyar's verdict on the Stanitsa and guard service" of 1571 relied on.Methodology. A preliminary analysis of the composition of the "team of authors" of experts on the peculiarities of the border guard service, gathered by Prince M. I. Vorotynsky to compile the document, is carried out, then it is supplemented by a source analysis of the monument itself, as well as the tactical experience of Prince M. I. Vorotynsky and his assistants.Results. It is concluded that the "Boyar verdict...", on the one hand, is based on the extensive tactical experience of people with practical knowledge of the steppe borders of Russia, on the other hand, is rigidly tied to regional forms of border defense and is not suitable for other areas of border service: in the west and in the east of the country.Research implications. The article analyzes the source in those aspects that have so far been ignored by specialists in the military history of Russia of the 16th–17th centuries.

Aim. Formation of scientific knowledge on ways to create a mechanism for managing the pricing of essential food products by legal means.Methodology. The trend of increasing legal regulation of the market has been traced. The work uses general scientific research methods, which allows you to take into account foreign experience in solving food security problems, as well as service tools, Overton windows, which allow you to identify trends in the development of modern legal consolidation of the foundations of the Food Security Doctrine. Analysis of the structure of market legal relations allows us to determine the direction of the formation of the legal doctrine for managing the pricing of essential food products.Results. The analysis showed the theoretical possibility of creating a mechanism for managing the pricing of essential food products by legal means.Research implications. Proposals were presented on the formation of a legal doctrine for managing the pricing of essential food products. The author’s edition of the concept of legal technology for the formation of pricing by manufacturers of essential food products has been introduced.

Zolmitriptan is the primary drug for the treatment of Migraine. However, the bioavailability of the drug is low and requires repetitive administration leading to side effects. Zolmitriptan's bioavailability can be improved by incorporating it into liposomes as a topical intranasal gel. The formulation was developed using a Central composite design employing a response surface approach. The new formulations were tested for particle size, shape, drug entrapment efficiency, and in vitro drug release. Permeation experiments and histopathology in rats were also conducted to determine the formulation's safety. The vesicle size was found to be in the range of 103.82±7.16 to 694.38±1.02 nm, zeta potential --19.28 to -32.8 mV, Entrapment Efficiency from 55.49±1.37 to 99.12±0.36 %, and cumulative drug release from 59.71±6.94 to 99.38±0.13 % respectively. In-vitro drug release of G1 and G3 gel formulations showed a non-Fickian released pattern during the studies. A comparison of the permeation coefficient of G1 (0.539 μg/cm2) and G3 (5.3 μg/cm2) showed a slight variation in the drug release rate after 24 hrs. For the liposomal gel and its solution, we found a significant difference in drug penetration of p0.05 after 12 hours compared to the control gel. There were substantial differences in bioavailability and pharmacokinetics between the optimal Liposomal Gel Formulation and other formulations, including the drug solution, liposomal suspension, and optimized formulation F12. The liposomal gel is non-irritating and safe for topical administration by histopathological investigations. Therefore, the study demonstrated that Zolmitriptan Liposomal gel has better efficacy, good tolerability, and enhanced bioavailability, making it an optimal treatment for acute Migraine.

The article examines the subjective factors of psychological readiness of employees of the penal system to resist manipulation. The results of an empirical study of the assertiveness of of the penal systems employees at the stage of university training and during their professional activities are presented. The psychological features of the Self-concept of employees of the penal enforcement system are shown. The study involved 75 employees of the penal correction system who study under higher education programs at the Academy of the Federal Penitentiary Service of Russia at the Faculties of Law, Economics, and Psychology and Probation, and 70 employees of the Federal Penitentiary Institution «Correctional colony No. 2» of the Federal Penitentiary Service of Russia in the Ryazan region, who carry out their professional activities in the security department, at the center for labor adaptation of convicts, in the department of educational work with convicts. The psychodiagnostic tools selected for the study make it possible to measure and analyze those personal qualities of the respondents that ensure their psychological readiness to resist manipulation by convicts. The study used the test questionnaire "Assertiveness Research" (modified by V. Kaponi, T.Novak) and the questionnaire "Self-assessment research using the Demo-Rubinstein method" (modified by A.M.Parishioners). The directions of psychological support for the process of developing anti-manipulative behavior skills are substantiated: expanding the zone of awareness regarding one's own values and beliefs, emotions and feelings; developing emotional intelligence, the ability to manage one's emotions; developing critical thinking; strengthening self-esteem, developing internal pillars of employees.

Статья посвящена исследованию колебательного движения среды и вопросам защиты строительных конструкций от колебаний. В частности, на основании общих дифференциальных уравнений движения идеально упругого тела разработана и предложена методика расчета оптимальных параметров виброзащитных экранов, расположенных на пути движения волн вибрации, что помогает снизить воздействия на строительные конструкции зданий и сооружений. Полученная методика апробирована авторами при реализации реального строительного проекта. Результаты апробации позволяют говорить о достоверности полученных результатов и эффективности созданной методики.