University of Travnik

Distal radius fracture (DRF) is the most common fall-related fracture and the most common fracture of the upper extremities. The purpose of the present study was to ascertain the effectiveness of paracetamol in pain modulation compared with paracetamol/tramadol in postoperative wrist fracture fixation. This interventional cohort study was conducted in a calculated sample size of 60 patients. The chosen criteria to evaluate the two groups during follow-up were: consumption of daily pain drugs; The Short Form (12) Health Survey; Visual analog scale (VAS); the Quick Disability Disabilities of the Arm, Shoulder and Score (QDASH); Complications; and Correlation VAS and QDASH. The endpoints assessment after the infiltrations were: from the moment of trauma to 35 days after the surgery. The first group (n=30) was a group treated by 1 tablet a day of 75 mg Tramadol + 650 mg Paracetamol (PT). The second group (n=30) was a group of patients treated by 1 tablet of paracetamol (P) 1 gr as needed Maximum 3 times a day. At the 35 th day, the mean VAS difference was p=0.027 for PT, also the mean SF-12 difference was p=0.016 for PT. At the 14th day from the surgery, the mean QDASH difference was p=0.042 for PT. Based on a drugs daily use as pain killer, paracetamol/tramadol was significantly better than paracetamol alone with lesser systemic complication. This reported the paracetamol/tramadol combination had more effective pain modulation than alone paracetamol with less complication in postoperative wrist surgery pain management among elderly patients.

<p>The House of Peoples of the Parliament of the Federation of Bosnia and Herzegovina, at its session held on March 4, 2025, unanimously adopted the Law on Protection from Domestic Violence and Violence Against Women, thereby introducing stricter protective measures for victims and harsher penalties for perpetrators of violence within the territory of the Federation of Bosnia and Herzegovina. Compared to the previous law, the new legal provisions impose greater responsibility and provide a broader scope of action for all those involved in the decision-making chain in the fight against domestic violence (police, judicial authorities, social work centers, and educational institutions). This paper will provide a detailed explanation of the innovations introduced by the Law: the expanded definition of a victim, electronic monitoring of offenders, sanctioning of online violence, establishment of an SOS hotline, prohibition of disclosing the identities of victims and perpetrators. Particular significance is given to the tightening of penalties for violating protective measures, which can now result in a prison sentence of up to three years, with no possibility of converting the sentence into a monetary fine.</p>

In this study, the asymmetric effect of oil and natural gas price shocks on the trade balance of 11 CESEE countries was estimated. These countries are net importers of oil and natural gas, and price shocks are often the cause of imbalances in trade. Quarterly data for the period 1994Q1 to 2023Q4 and nonlinear ARDL model were used. In the long run, a significant asymmetric effect due to the oil price shock on the trade balance of Bulgaria, Czechia, Latvia and Slovenia was found, as well as a significant asymmetric effect due to the natural gas price shock on the trade balance of Croatia. Also in the long run, a significant asymmetric effect due to wholesale prices on the trade balance of Romania, Bulgaria and Croatia was found as well as a significant asymmetric effect due to industrial production on the trade balance of Croatia, Czechia and Latvia was found, in addition to a significant asymmetric effect due to the exchange rate on the trade balance of Czechia, Poland and Romania.

O presente estudo teve como objetivo geral investigar, com base em evidências científicas, o impacto da idade materna avançada na gravidez e no parto. Foram estabelecidos como objetivos específicos: identificar as principais complicações gestacionais associadas à idade materna avançada, como hipertensão gestacional, diabetes mellitus gestacional e pré-eclâmpsia; examinar a associação entre a idade materna e a ocorrência de intercorrências durante a gestação. Trata-se de uma revisão integrativa de literatura. A busca foi realizada na base de dados da Scielo (Scientific Electronic Libery Online), LILACS (Literatura latino-americana e Caribe); Biblioteca Virtual de Saúde (BVS) com a utilização dos seguintes descritores em ciências da saúde: "idade materna avançada", "complicações gestacionais", "desfechos neonatais", e " parto" no período entre 2018 a 2024. Os estudos analisados confirmam que mulheres com idade materna avançada enfrentam um risco elevado de hipertensão gestacional, diabetes mellitus gestacional e pré-eclâmpsia, além de apresentarem taxas mais altas de cesarianas e partos prematuros. Estes resultados reforçam a importância de um acompanhamento mais rigoroso e uma abordagem adaptada para gerir as gestações em mulheres mais velhas, visando minimizar riscos e promover melhores desfechos tanto para a mãe quanto para o bebê.Parte inferior do formulário

Abstract This paper investigates performance optimization of Gaussian mixture algorithms in the context of mathematical analysis. Using advanced optimization methods, adapted to the specific requirements of mathematical problems, we investigate how to improve the efficiency and precision of Gaussian mixture algorithms. Through experimental results and analyses, we demonstrate the benefits of these optimizations on various applications of mathematical analysis. In addition, we focus on developing new techniques to address challenges arising from the application of Gaussian mixture algorithms in mathematical analysis, such as overlearning and scalability problems. Through detailed experiments on different data sets and mathematical analysis problems, we provide deeper insight into the performance and applicability of the optimized algorithms. Our work also highlights the importance of the adaptability of algorithms in different contexts of mathematical analysis and the need for continuous improvement of optimization methodologies in order to adequately respond to the dynamic demands of the research community..

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and lethal tumor, characterized by hypercalcemia and early onset and associated with germline and somatic SMARCA4 variants. To identify all known cases of SCCOHT in the Slovenian population from 1991 to 2021 and present genetic testing results, histopathologic findings, and clinical data for these patients. We also estimate the incidence of SCCOHT. We conducted a retrospective analysis of hospital medical records and data from the Slovenian Cancer Registry in order to identify cases of SCCOHT and obtain relevant clinical data. Histopathologic review of tumor samples with assessment of immunohistochemical staining for SMARCA4/BRG1 was undertaken to confirm the diagnosis of SCCOHT. Germline and somatic genetic analyses were performed using targeted next-generation sequencing. Between 1991 and 2021, we identified 7 cases of SCCOHT in a population of 2 million. Genetic causes were determined in all cases. Two novel germline loss-of-function variants in SMARCA4 LRG_878t1:c.1423_1429delTACCTCA p.(Tyr475Ilefs*24) and LRG_878t1:c.3216-1G>T were identified. At diagnosis, patients were ages 21 to 41 and had International Federation of Gynecology and Obstetrics, or FIGO, stage IA-III disease. Outcomes were poor, with 6 of 7 patients dying of disease-related complications within 27 months from diagnosis. One patient had stable disease for 12 months while receiving immunotherapy. We present genetic, histopathologic, and clinical characteristics for all cases of SCCOHT identified in the Slovenian population during a 30-year period. We report 2 novel germline SMARCA4 variants, possibly associated with high penetrance. We estimate the minimal incidence of SCCOHT to be 0.12 per 1 million per year.

ABSTRACT The main objective of this paper is to assess the asymmetric effect of exchange rate volatility on the exports and imports of 17 Central, East and Southeast European (CESEE) countries. For this purpose, the linear and non-linear autoregressive distributed lag (ARDL) model and annual data for the 1995–2020 period were used. Empirical results of the assessment showed an asymmetric effect of exchange rate volatility on exports in nine countries and a symmetric effect on exports in four countries. Similarly, an asymmetric effect of exchange rate volatility on the imports of 10 countries and a symmetric effect on the imports of five countries were found. Research implications of this study are important to enable policy makers to understand that results obtained in earlier studies through the linear model may lead to incorrect views about the effect of exchange rate volatility on the exports and imports of CESEE countries.