University of the Pacific

Gastronomy is a highly competitive and constantly evolving field worldwide. Some emerging countries, like Peru, have been among those that have solidly established their culinary art on the international stage over the past few decades. The creation of fusion cuisine, which merges elements from French, Italian, Spanish, Chinese and Japanese cultures, has led to a significant product offering for various markets. Our research aims to demonstrate how Hanzo, a specialized Peruvian–Japanese restaurant, has focused on value creation as the foundation for business growth. An important element about the creation and performance of this restaurant is the entrepreneurial capability of the founder. He has established an innovation culture based on original dishes and personal service. Using the case study approach, we analyzed the iterative process among the involved actors. Among Hanzo’s achievements are its recognition as one of the top Nikkei–Japanese restaurants, which enhances its market position and attracts a loyal customer base. We found relevant lessons on how to solidly unify different cultures/cuisines for creating value through fusion cuisine. Implications for management include analyzing new ways to co-create value through innovation, oriented personalization and integrating employees according to the values of strong cultures.

This study evaluated the longitudinal stability of transverse changes in patients treated with the Invisalign First system (IFS; Align Technology Inc, Tempe, Ariz) and hyrax expanders during the mixed dentition, followed through the permanent dentition. The objective was to determine whether expansion achieved during the mixed dentition was maintained through the transition to the permanent dentition. This retrospective longitudinal study included 119 patients: 44 patients treated with IFS, 36 patients treated with hyrax, and 39 untreated controls. Arch width changes at the canines, premolars, and first molars were measured on digital study models at 3 time points: pre-phase 1 treatment (T1), post-phase 1 treatment (T2), and pre-phase 2 evaluation (T3). Vertical skeletal changes were evaluated in a cephalogram subgroup. Statistical analyses included analysis of variance and linear mixed-effects models. Both IFS and hyrax groups showed greater maxillary arch width increases from T1 to T3 (IFS: 1.8-2.8 mm; hyrax: 2.2-3.7 mm) than controls (0.4-1.2 mm; P <0.0001). At T2, hyrax showed significantly greater interpremolar and intermolar expansion (4.1-4.8 mm) than IFS (1.9-2.8 mm), but more relapse from T2 to T3. The IFS group also showed increased mandibular arch width from T1 to T3 (1.9-2.9 mm) compared with controls (P <0.05). No significant vertical skeletal changes from T1 to T3 were observed. Both IFS and hyrax produced maxillary arch expansion that was maintained throughout the transition from mixed to permanent dentition. The IFS also showed stable mandibular arch expansion, supporting its use for mild crowding or transverse deficiencies without long-term vertical effects.

Purpose This study aims to address a critical gap in organisational attractiveness (OA) research by developing and validating Peru’s first culturally adapted measurement model (ENATO). Design/methodology/approach This study used a mixed-methodological approach that combined qualitative and quantitative analysis. Researchers conducted interviews and expert panels to identify components of organisational attractiveness and develop an item pool. The resulting scale underwent validation through multiple exploratory and confirmatory factor analyses. Findings The results show that OA comprises four dimensions: individual beliefs, organisational beliefs, intentions and actions. The final version of the scale consists of 28 items. Research limitations/implications Although this study is limited by non-probability sampling, the Modelo de medición integral del Atractivo Organizacional (ENATO) model offers a culturally informed, multidimensional framework that extends organisational attractiveness research by integrating beliefs, intentions and actions and highlighting the contextual variability of attitudinal components. Practical implications The final scale provides organisations with a culturally adapted diagnostic tool that helps identify factors shaping employer attractiveness, enabling more targeted recruitment, onboarding and retention strategies. Originality/value To the best of the authors’ knowledge, as the first OA model tailored to Latin America, this study challenges universal assumptions about employer branding and provides organisations with a practical tool to enhance recruitment and retention in emerging markets.

Restorative justice within the juvenile justice system has gained increasing attention as an alternative to punitive approaches, particularly in relation to the social reintegration of adolescents in conflict with the law, while complementary interventions such as music therapy are often implemented to support emotional regulation, social skills, and personal development within restorative contexts. This observational, cross-sectional study examined the associations between restorative justice practices, participation in music therapy, and indicators of social reintegration among 317 adolescents involved in restorative programs in Peru. Data were collected using a structured survey composed of ordinal-scale items assessing dimensions of restorative practices, engagement in music therapy, and perceived social reintegration, with the instrument demonstrating satisfactory internal consistency. Statistical associations were analysed using Somers’ d, a non-parametric measure appropriate for assessing ordinal associations in observational research. The results revealed statistically significant and directionally consistent associations between restorative justice practices and social reintegration outcomes, as well as positive associations between participation in music therapy and higher levels of reported social reintegration. These findings should be interpreted in light of the study’s cross-sectional design and non-probability sampling strategy, which limit causal inference and generalizability. While the results are consistent with the potential relevance of integrating music-based activities within restorative contexts, future research employing experimental or longitudinal designs is required to examine causal mechanisms and long-term effects and to further clarify the role of therapeutic interventions in supporting the social reintegration of justice-involved adolescents.

ABSTRACT Cancer cell-autonomous type 1 interferon (IFN-1) production and signaling is frequently activated in response to DNA damage and has been associated with the development of therapy resistance in several cancer types. However, its cell-autonomous role in driving resistance in high-grade serous ovarian cancer (HGSOC), a disease defined by near-universal exposure to genotoxic therapy as frontline treatment, remains unclear. Specifically, whether IFN-1 functions in HGSOC as only a response to genotoxic stress or can independently act in driving resistance phenotypes has not been studied. Utilizing a syngeneic patient-derived model of cisplatin-sensitive (SE) and -resistant (CR) HGSOC, we demonstrate that chronic cisplatin exposure is associated with enrichment of IFN-1 signaling and the interferon-related DNA damage resistance signature (IRDS). Acute cisplatin treatment elicited dynamic, temporal IFN-1 signaling and responses in both sensitive and resistant cells, indicating a conserved stress response in resistant cells. Chronic, low-level exposure to exogenous IFNβ, in the absence of a DNA-damaging agent, was sufficient to phenocopy several features of chronic cisplatin driven resistance, including reduced therapeutic sensitivity, cell cycle arrest, and decreased proliferation. Notably, IFNβ driven resistance occurred without sustained IRDS or canonical interferon stimulated gene (ISG) induction, revealing alternative mechanisms for IFN-1 mediated therapy resistance. Together, these findings identify IFNβ as a functional driver of the development of resistance-associated phenotypes and highlight cell-autonomous IFN-1 signaling as a potential biomarker for resistance and a therapeutic target in platinum-resistant disease.