VinTech (United States)

This study examines whether organizations that adopt structured, proactive neurodivergent-inclusive practices (NII) demonstrate measurable differences in workforce productivity and voluntary retention compared to organizations that limit their approach to compliance-based accommodations. Drawing on human capital theory and organizational psychology frameworks, we analyzed data from 242 mid-to-large organizations across four industry sectors using a cross-sectional, mixed-methods design. Neurodivergent inclusion was operationalized through a validated 18-item composite instrument (NII Index, alpha = .87) measuring structural accommodations, cultural integration, and managerial capability. Productivity was indexed via objective OKR attainment scores; retention was measured as annual voluntary turnover rate.

ObjectiveTo describe the composition of the gut microbiota of women living with fibromyalgia, compared with controls, and examine the relationship between fecal microbiota and clinical features of fibromyalgia.MethodsNew Zealand women meeting American College of Rheumatology fibromyalgia criteria and age‐matched controls provided fecal samples and completed validated surveys assessing pain, disorders of gut–brain interaction (DGBI), headaches, sleep quality, oral health, cognition, anxiety, depression, diet, and quality of life. Metatranscriptomic analysis identified phyla, genera, and species in fecal samples. Correlation coefficients were calculated for each α‐diversity metric against clinical variables. Welch's t‐test or Wilcoxon rank test was applied for binary clinical variables. Generalized linear models analyzed associations in the fibromyalgia group, adjusting for age, body mass index, and diet. Data processing and analysis used R version 4.2.1, with the Benjamini–Hochberg formula controlling for false discovery rate at ≤0.10 to minimize type 1 error risk.ResultsNo statistically significant differences were seen in the microbial expression in fecal samples of women with fibromyalgia (n = 104) compared with controls (n = 52). Significant associations among three species from the Bacteroidetes phylum and cognitive impairment were observed. Fusobacteriota was significantly associated with Rome IV(B) DGBI, specifically epigastric pain syndrome. A strong association was observed between oral microbiota in feces and upper gastrointestinal DGBI, indicating both negative and positive correlations in this population.ConclusionNo overall differences in fecal microbial expression were found in women with fibromyalgia. However, Bacteroidetes and Fusobacteriota phyla were significantly associated with cognitive impairment and epigastric pain syndrome, respectively.

This study evaluates the three-dimensional (3D) printing materials used in Fused Deposition Modeling (FDM) printing technology. 3D printing technology has been developing strongly, becoming an effective support tool in production and research. The 3D printing process involves many stages, with many parameters affecting the quality and properties of the product, in which 3D printing material is one of many essential factors affecting that process. The study conducts a comprehensive assessment of the most common materials in 3D printing technology to determine the advantages and limitations of precisely five types of materials: Polylactic acid, acrylonitrile butadiene styrene, polyethylene terephthalate glycol-modified, thermoplastic polyurethane, and acrylonitrile styrene acrylate. With 3D printing, parameters such as sintering temperature, printing speed, and layer thickness are kept constant. These parameters are applied equally to all five material samples. The experiment evaluates the tensile strength of materials. The study results provide an overview of the properties and applicability of 3D printing materials, helping to select materials suitable for specific FDM 3D printing technology applications.

Abstract Functional gastrointestinal disorders present diagnostic and therapeutic challenges, and there is a strong need for molecular markers that enable early health insights and intervention. Herein, we present an approach to assess the gut microbiome with stool-based gut metatranscriptome data from a large adult human population (n = 80,570), using irritable bowel syndrome as an example that features both an abnormal gut microbiome and a spectrum of distinct conditions. We develop a suite of eight gut microbial functional pathway scores, each of which represents the activity of a set of interacting microbial functional features (based on KEGG orthology) relevant to known gut biochemical activities. We use a normative approach within a subpopulation (n = 9,350) to define “Good” and “Not Optimal” activities for these transcriptome-based gut pathway scores. We hypothesize that Not Optimal scores are associated with irritable bowel syndrome (IBS) and its subtypes (i.e., IBS-Constipation, IBS-Diarrhea, IBS-Mixed Type). We show that Not Optimal functional pathway scores are associated with higher odds of IBS or its subtypes within an independent cohort (n = 71,220) using both the Rome IV Diagnostic Questionnaire as well as self-reported phenotypes. Rather than waiting to diagnose IBS after symptoms appear, these functional pathway scores can help to provide early health insights into molecular pathways that may contribute to IBS. These molecular endpoints could also assist with measuring the efficacy of practical interventions, developing related algorithms, providing personalized nutritional recommendations, diagnostic support, and treatments for gastrointestinal disorders like IBS. Graphical Abstract

Hybrid immunity can become a turning-point opportunity to defeat the infection in context with the current pandemic scenario. Adopting policies aligned with the data mentioned above may be particularly beneficial for regions like Latin America. While this region shares only ~5% of the world population, it accumulates +16% of the ~200 million COVID-19 total cases, so far reported1. Acknowledging the reduced diagnostic capabilities of these countries, this entire area is probably one of the most affected globally, leading to one of the more numerous populations of convalescent people. From both an economic and pharmacological perspective, applying a one-dose regime of pertinent vaccines to convalescent individuals is sustainable5. As COVID-19 survivors may need just one vaccination to achieve high levels of protective immunity, massive antibody screening for SARS-CoV-2 spike antibodies could help prioritize and free up doses, optimize vaccine supply efficiency, and surpass problems linked to the current vaccine manufacturing bottleneck

A Lewis base additive is used to stimulate vertical orientation and even the distribution of low dimensional perovskite crystallites, improving photovoltaic performance.

International audience

Towards improved lanthanide complexes for two-photon mediated singlet oxygen production: The very large intersystem crossing efficiency results from the combination and interplay of bromine atom substituents, placed along the π-conjugated antenna, and a heavy rare-earth element coordinated to a central TACN ligand. Two-photon-activated singlet oxygen generation leads to tumor cell death, which illustrates the potential of this new class of compounds as theragnostic agents. More information can be found in the Full Paper by M. Gary-Bobo, C. Andraud, C. Monnereau, O. Maury, et al. on page 9026.