Visual Health Solutions (United States)

Aberrant sialylation is accepted as a carcinogenic biomarker. In previous work, fluorescently labeled wheat germ agglutinin (WGA) distinguished between cancerous and normal oral biopsies. The purpose of this study was to investigate WGA-fluorescein isothiocyanate (FITC) as a point-of-care tool for detecting oral malignant and dysplastic lesions in vivo. Subject recruitment was divided into two groups: (1) the clinically normal oral mucosa group; or (2) the presence of clinically suspicious oral lesion(s) group. A WGA-FITC solution was topically applied to observable lesions or to half the subject's mouth (sagittal plane) if lesions were absent. Fluorescent molecular imaging was used to evaluate WGA-FITC localization. Fluorescent imaging in 55 subjects demonstrated that WGA-FITC could detect histopathologically-confirmed cancerous and dysplastic lesions with high sensitivity (100% and 81%, respectively) and specificity (82%). This study supports in vivo fluorescent molecular imaging of WGA-FITC to visualize aberrant sialic acid expression associated with carcinogenesis. This technique resulted in the immediate chairside detection of oral cancerous and dysplastic lesions.

Time series modeling is proposed for identification of targets whose images are not clearly seen. The model building takes into account air turbulence, precipitation, fog, smoke and other factors obscuring and distorting the image. The complex of library data (of images, etc.) serving as a basis for identification provides the deterministic part of the identification process, while the partial image features, distorted parts, irrelevant pieces and absence of particular features comprise the stochastic part of the target identification. The missing data approach is elaborated that helps the prediction process for the image creation or reconstruction. The results are provided.

Nanoimprint is an emerging lithographic technology that promises high-throughput pattering of nanostructures. Based on the mechanical embossing principle, nanoimprint technique can achieve pattern resolutions beyond the limitations set by the light diffraction or beam scattering in other conventional techniques. The difficulty arises with the exact 90⁰ setting of the mould above the wafer. Proposed is the method of achieving this perpendicularity by the means of the crystallographic properties of Si or GaAs and the matrix made of the above-mentioned materials.

In the recent years, multifarious devices, systems and applications working in the THz frequency domain have been brought to life. Many of them are meant for security and military purposes, such as non-invasive detection of explosives, weapons, biological and chemical agents, etc. The problem, however, is not only with the detection and ever-increasing accuracy of measurements but often with understanding of what is seen; discriminating between the objects and the materials they are made of. It seems especially important to create an automatic or semi-automatic system and thus release the operator from constant watching. The proposed solution is an adaptive intelligent system based on usage of THz waves as the probing signal by means of mathematical statistics. Time series analysis is one of the forms that is employed in this research. The adaptivity of the system to various objects under investigation is based on the data base installed as well as on the possibility of changing of the detection system's parameters and modes of operation depending on the signal received from the identified objects. In other words, the suggested method allows for the detection system to switch from, say, the metal object mode to the pharmaceutical one and so forth.

You can think of the C preprocessor as a separate program that runs before the compiler, with its own simple, line-oriented grammar and syntax. In previous chapters, we introduced two preprocessor directives—the #define command for naming a constant and the #include command for including additional source files. This chapter discusses both of these directives in greater detail and also describes other preprocessor directives that have not been mentioned yet. Briefly, the preprocessor gives you the following capabilities: Macro processing. Inclusion of additional C source files. “Conditional compilation,” which enables you to conditionally compile sections of C source contingent on the value of an arithmetic expression. KeywordsLine NumberInput StreamSource FileConditional ExpressionHead FileThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.