Walsh University

The Albertine Rift, located in the eastern part of the Democratic Republic of Congo (DRC), constitutes a significant ecosystem, characterised by an exceptional diversity of aquatic environments, including lakes, rivers, wetlands, and peat lands. These ecosystems play a fundamental role in the socio-economic livelihoods of riparian communities. This study adopts a multidisciplinary approach, drawing on the concepts of ecosystem services, socio-ecological systems, and political ecology. It highlights the multiple functions of these aquatic environments, namely fisheries, irrigated agriculture, domestic water supply, artisanal activities, ecotourism, spirituality, and cultural cohesion. Aquatic ecosystems are central to food security, rural economic development, and the preservation of cultural identities. In addition, they provide essential regulating services, such as water resource management, water purification, and carbon sequestration. Collectively, these services enhance the resilience of local communities in the face of climatic variability and socio-political crises. Despite their importance, these ecosystems are increasingly threatened by pollution, uncontrolled urban expansion, overexploitation of resources, climate change, and institutional lacunas. Their degradation is driven by multiple interacting factors, including population pressure and conflicts over natural resource use. In response, this study advocates for an integrated and participatory governance framework that emphasises the valorisation of local knowledge. It calls for ecological restoration initiatives, the promotion of a sustainable local economy, capacity building within communities, and increased investment in environmental education. Under such strategic orientations, the aquatic ecosystems of the Albertine Rift could serve as key pillars for sustainable development, peacebuilding, and socio-ecological resilience in the Democratic Republic of Congo.

Pengelompokan data pelanggaran siswa semester 2 digunakan untuk melatih tingkat kedisiplinan siswa. Klasifikasi data ini memakai metode data mining untuk menentukan kedisiplinan siswa secara objektif. Metode data mining yang digunakan di penelitian ini Adalah Naïve Bayes. Klasifikasi data ini menggunakan perhitungan manual dengan metode gaussian naïve bayes dimana menggunakan pendekatan bilangan bulat, tidak hanya diuji manual tetapi juga dengan tools rapidminer. Teknik yang digunakan di rapid miner untuk membagi data menjadi beberapa bagian atau fold, dimana bagian data training dan testing dibagi dengan cross validation. Teknik ini bertujuan agar hasil evaluasi menjadi lebih tepat, evaluasi dibuat dengan confusion matrix dengan perhitungan kurasi, presisi, dan recall dan F1 score. Pengelompokan data dibagi menjadi 2 kategori yaitu disiplin dan kurang disiplin. Hasil penelitian menggunakan Naïve bayes dengan optimasi GA memperoleh nilai accuracy sebesar 89,47% dengan menggunakan teknik cross validation dengan sampling type stratified yang membantu menghasilkan evaluasi yang lebih stabil.

This contribution investigates the influence of high frequencies as well as harmonics on refractive field grading material for medium voltage cable accessories. The dielectric losses of the refractive field grading material are first measured and evaluated to determine the influence of harmonics. Then, a model of a medium voltage cable joint incorporating the test sample as field grading material is computed using Finite Element Method (FEM). Using a Multiphysics approach, the electrothermal behaviour of the model is evaluated under the influence of high frequencies and harmonics. Preliminary results show that high frequencies do not significantly increase the electric field strength on the interface. Additionally, high frequencies up to 2 kHz also d o not result in any significant temperature increase in the field grading material. Similarly, under harmonics, the increase in the electric field strength remains negligible.

This study explores the critical role of teacher engagement in enhancing teaching performance and student academic achievement in secondary schools in Kathmandu, Nepal. Recognizing that engaged teachers are motivated and dedicated, this research examines the moderating effect of teamwork on teachers’ engagement following professional training. Data were collected from a sample of 320 teachers from both public and private schools and analyzed using descriptive statistics in SPSS and Structural Equation Modeling (SEM) in AMOS. Findings reveal a significant positive relationship between teacher training and professional development, confirming that training directly influences teacher engagement. However, teamwork as a moderating factor did not show a significant catalytic effect on enhancing engagement post-training. This study contributes to the literature by identifying potential gaps in the translation of training into engagement through teamwork, offering new insights into the challenges of fostering collaborative practices that support teacher development in the Nepalese educational context.

هدفت هذه الدراسة إلى تقديم تحليل نقدي شمولي لأدوات التشخيص وآليات التدخل المُستحدثة لمعالجة صعوبات تعلم الرياضيات المتقدمة (AMLD)، والتي تشمل محاور الجبر التجريدي، والتفاضل والتكامل، والهندسة الفراغية، ضمن إطار زمني يمتد من عام 2000 حتى 2023. وقد اعتمدت الدراسة على منهجية المراجعة المنهجية النقدية (Systematic Critical Review) وفقاً لبروتوكول PRISMA، بتحليل 127 دراسة مستخلصة من قواعد بيانات أكاديمية مرموقة. أكدت النتائج المحورية أن فعالية التشخيص تتوقف على تبني إطار تكاملي متعدد الأبعاد يشمل الجوانب المعرفية، والانفعالية، وما وراء المعرفية. وعلى الرغم من أن أدوات القياس المعرفية مثل اختبار التفكير الجبري (ATT) أظهرت فعالية متوسطة (حجم أثر d=0.62)، فقد سجلت استراتيجيات التدخل القائمة على التمثيلات المتعددة والتدريب ما وراء المعرفي أعلى مستويات الفعالية، بأحجام أثر بلغت d=0.79 وd=0.75 على التوالي. كما كشفت الدراسة عن ثلاث تحديات بحثية حرجة: أولاً، النقص الحاد في أدوات القياس المُعايرة ثقافياً، حيث أن 15% فقط منها صالحة للاستخدام في السياقات العربية؛ ثانياً، ضعف التوظيف الفعال للتكنولوجيا المتقدمة في التشخيص (بنسبة 12% فقط تستخدم تقنيات الذكاء الاصطناعي)؛ وثالثاً، الإغفال المنهجي لتشخيص صعوبات الهندسة الفراغية فيما يقارب 73% من الأبحاث المنشورة

Aim: Denosumab and bisphosphonates are the main treatments for osteoporosis in residential aged care (RAC). Strict adherence to 6-monthly denosumab dosing is critical as delayed doses can result in bone resorption and vertebral fractures. If denosumab

Abstract BACKGROUND CDKN2A/B (cyclin-dependent kinase inhibitor 2A/B) gene alterations are integral to the diagnosis and prognostication of IDH-mutant gliomas. CDKN2A/B status is commonly assessed by next generation sequencing (NGS) or inferred from loss of the surrogate marker MTAP (5’-methylthioadenosine phosphorylase) by immunohistochemistry, since the MTAP gene (located adjacent to the CDKN2A/B locus on chromosome 9p21) is often presumed deleted when CDKN2A/B is deleted. However, with MTAP deletion emerging as a therapeutic target in gliomas, directly characterising its incidence and implications is essential. METHODS The incidence of CDKN2A/B and MTAP deletions was evaluated by NGS multigene panels across glioma subtypes within the Australian national Molecular Screening and Therapeutics (MoST) and Cancer Screening Programs (CaSP). All patients with glioma (glioblastoma, astrocytoma, oligodendroglioma) enrolled between June 2017 and April 2025 were reviewed. Sequencing was performed using FoundationOne CDx, TruSight Oncology 500, TruSight Tumor 170, or AVENIO. For panels not directly assessing MTAP, a bioinformatic algorithm was used to predict deletion based on copy number variation in non-targeted regions. RESULTS Of 785 gliomas, 328 (41.8%) had CDKN2A deletion and 271 (34.5%) had CDKN2A/B codeletion. MTAP homozygous deletion, whether predicted or directly measured, was observed in 230 (70.1%) with CDKN2A deletion and in 200 (73.8%) with CDKN2A/B codeletion. MTAP deletion was not identified in the absence of CDKN2A deletion. An additional 19 patients harboured CDKN2A/B mutations without associated MTAP deletion. When stratified by IDH mutation status, CDKN2A deletion occurred in 40 of 200 IDH-mutant gliomas (20%), with co-occurring MTAP deletion in 31 cases (77.5%); and in 288 of 585 IDH-wildtype gliomas (49.2%), with co-occurring MTAP deletion in 199 (69.1%). CONCLUSIONS MTAP deletions can no longer be inferred from CDKN2A/B status alone. Beyond NGS, evaluating other methods of determining MTAP deletion status such as immunohistochemistry would be worthwhile as a cost-effective method for screening and/or validation.