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Abstract. This study introduces a novel approach to post-processing (i.e. downscaling and bias-correcting) reanalysis-driven regional climate model daily precipitation outputs that can be generalised to ungauged mountain locations by leveraging sparse in situ observations and a probabilistic regression framework. We call this post-processing approach generalised probabilistic regression (GPR) and implement it using both generalised linear models and artificial neural networks (i.e. multi-layer perceptrons). By testing the GPR post-processing approach across three Hindu Kush Himalaya (HKH) basins with varying hydro-meteorological characteristics and four experiments, which are representative of real-world scenarios, we find it performs consistently much better than both raw regional climate model output and deterministic bias correction methods for generalising daily precipitation post-processing to ungauged locations. We also find that GPR models are flexible and can be trained using data from a single region or multiple regions combined together, without major impacts on model performance. Additionally, we show that the GPR approach results in superior skill for post-processing entirely ungauged regions, by leveraging data from other regions as well as ungauged high-elevation ranges. This suggests that GPR models have potential for extending post-processing of daily precipitation to ungauged areas of HKH. Whilst multi-layer perceptrons yield marginally improved results overall, generalised linear models are a robust choice, particularly for data-scarce scenarios, i.e. post-processing extreme precipitation events and generalising to completely ungauged regions.

The new high selective mAChRs M3 inhibitors with IC 50 in nanomolecular ranges, which can be the prototypes for effective COPD and asthma treatment drugs, were discovered with computational approaches among trifluoromethyl containing hexahydropyrimidinones/thiones. Compounds [6-(4-ethoxy-3-methoxy-phenyl)-4-hydroxy-2-thioxo-4-(trifluoromethyl)hexahydropyrimidin-5-yl]-phenyl-methanone (THPT-1) and 5-benzoyl-6-(3,4-dimethoxyphenyl)-4-hydroxy-4-(trifluoromethyl)hexahydropyrimidin-2-one (THPO-4) have been proved to be a highly effective (with IC 50 values of 1.62·10 -7 M and 3.09·10 -9 M, respectively) at the same concentrations significantly competitive inhibit the signal conduction through mAChR3 in comparison with ipratropium bromide, without significant effect on mAChR2, nicotinic cholinergic and adrenergic receptors.

If $G$ is a group acting on a set $\Omega$ and $\alpha, \beta \in \Omega$, the digraph whose vertex set is $\Omega$ and whose arc set is the orbit $(\alpha, \beta)^G$ is called an {\em orbital digraph} of $G$. Each orbit of the stabiliser $G_\alpha$ acting on $\Omega$ is called a {\it suborbit} of $G$. A digraph is {\em locally finite} if each vertex is adjacent to at most finitely many other vertices. A locally finite digraph $\Gamma$ has more than one end if there exists a finite set of vertices $X$ such that the induced digraph $\Gamma \setminus X$ contains at least two infinite connected components; if there exists such a set containing precisely one element, then $\Gamma$ has {\em connectivity one}. In this paper we show that if $G$ is a primitive permutation group whose suborbits are all finite, possessing an orbital digraph with more than one end, then $G$ has a primitive connectivity-one orbital digraph, and this digraph is essentially unique. Such digraphs resemble trees in many respects, and have been fully characterised in a previous paper by the author.

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CORRESPONDENCE: TRENDS IN VIOLIN PLAYING F. B. F. B. London, N.W. Search for other works by this author on: Oxford Academic Google Scholar Music and Letters, Volume XXXI, Issue 2, April 1950, Page 183, https://doi.org/10.1093/ml/XXXI.2.183 Published: 01 April 1950