Publications from 2021 to 2026
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An injectable bioadhesive hyaluronic acid hydrogel formulated with drug-loaded microparticle cross-linkers for co-delivery of dexamethasone and lidocaine to the inner ear.
Emerging growth factor delivery hydrogel system for wound healing
Usenamine a potentiates anti-CRC activity of sorafenib by inducing autophagy and inhibiting YAP pathway through targeting SOD2.
Analyzing adverse event signals of aprepitant using FAERS database data in real-world settings: Broadening the adverse event spectrum of aprepitant and its clinical implications
Aprepitant, a neurokinin-1 receptor antagonist approved by the US FDA for chemotherapy- and postoperative-induced nausea and vomiting, has limited real-world safety data; we therefore interrogated the FDA Adverse Event Reporting System from Q1 2004 to Q3 2023 to systematically characterize aprepitant-associated adverse drug events. After extracting 8271 reports on 3033 patients, we applied a combined signal detection framework – reporting odds ratio, proportional reporting ratio and the Bayesian confidence propagation neural network with multi-item gamma Poisson shrinker – and analyzed demographics, reporter profiles and temporal trends. Women represented 54.10% of cases, the 45 to 65-year age group 27.86%, and healthcare professionals filed 65.64% of reports; the United States, France, Japan, the United Kingdom, and China contributed most cases, peaking during 2013 to 2019. While labeled toxicities were confirmed, novel high-strength signals emerged, including joint deposition, oral mucosal roughening, encephalopathy, dysplasia, febrile myelodysplasia, small cell lung cancer and tonic-clonic movements, whereas dyspnea and nausea remained the 2 most frequently reported events. These findings corroborate known risks and unveil previously under-recognized aprepitant related adverse reactions, providing actionable safety guidance for clinicians and suggesting that the strong joint deposition signal warrants prospective investigation of aprepitant in arthritic disorders.
Read moreProduct-induced dual amplification strategy for chloramphenicol detection based on catalytic hairpin assembly and DNA tetrahedron nanomachines
FFK-net: A feature fusion-based kolmogorov-arnold network for liver tumor segmentation
Trifunctional nanoparticles accelerate diabetic wounds healing via oxidative-immune-vascular coordination.
12Long-Term Glycemic Control and the Risk of Liver Stiffness Progression and Liver-Related Events in MASLD.
Nonenzymatic autonomous assembly of DNA network structures mediated by only one palindromic DNA fragment for miRNA detection
Atmospheric microplastic deposition in 24 Chinese cities with different socio-economic development levels.
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