Wojewódzki Inspektorat Ochrony Środowiska w Warszawie

The article presents the state of innovativeness of the Polish economy in 2012–2015. The author of the article emphasizes that a structured organizational culture based on ethical values in organizations will foster the development of cooperation among organizations, among others. in the form of clusters. This will lead to the appearance of various forms of innovation in the organizations, which will lead to an improvement in the quality of life of Polish society in the context of sustainable socio-economic development of the country.

Through the high dilution technique, we obtained macrocyclic ion pair receptors R1 and R2, an anion receptor R3, and a fluorescent sensor R4 using a combination of particular members of simple libraries consisting of synthesized diamines and methyl squarates, respectively. The receptors were investigated in terms of anion and ion pair binding using the 1H NMR titration method in DMSO-d6. We found that the major contribution to the anion binding comes from the interaction with the squaramide protons rather than with the amide functions of the receptors. The receptors demonstrated the highest affinity towards benzoates and sulfates over the anions tested, and in the case of sulfate binding more complex equilibria in solution were observed. Unlike the anion receptor R3, the ion pair receptor R1 was found to recognize anions in an enhanced manner with the assistance of sodium or potassium cations. Tethering of a simple fluorophore in close proximity to the amide function of receptor R4 resulted in an optical ion pair sensor selective towards sulfates. DFT calculations carried out for the 1 : 1 complexes of R3 with the anions helped clarify this selectivity, showing more effective participation of tetrahedral sulfate anions in binding with the amide function than in the case of benzoates or chlorides.

Arginase is involved in a wide range of pathologies including cardiovascular diseases and infectious diseases whilst it is also a promising target to improve cancer immunotherapy. To date, only a limited number of inhibitors of arginase have been reported. Natural polyphenols, among them piceatannol, are moderate inhibitors of arginase. Herein, we report our efforts to investigate catechol binding by quantum chemistry and generate analogues of piceatannol. In this work, we synthesized a novel series of amino-polyphenols which were then evaluated as arginase inhibitors. Their structure-activity relationships were elucidated by deep quantum chemistry modelling. 4-((3,4-Dihydroxybenzyl)amino)benzene-1,2-diol 3t displays a mixed inhibition activity on bovine and human arginase I with IC50 (K i) values of 76 (82) μM and 89 μM, respectively.

Using a fluid particle dynamics method we numerically investigate the motion of a spherical Janus particle suspended in a binary liquid mixture, which emerges under heating of one-half of a colloid surface. The method treats simultaneously the flow of the solvent and the motion of the particle, hence, the velocity of the particle can be computed directly. Our approach accounts for a phenomenon of critical adsorption, therefore, a particle that is adsorptionwise nonneutral is always completely covered by an adsorption layer (droplet). In order to establish the mechanism of self-propulsion, we study systematically various combinations of adsorption preference on both hemispheres of the Janus colloid as function of the heating power for symmetric and nonsymmetric binary solvents and for various particle sizes in three spatial dimensions. Only for a particle for which the heated hemisphere is neutral whereas the other hemisphere prefers one of the two components of the mixture does the reversal of the direction of motion occur. The particle self-propels much faster in nonsymmetric binary solvents. Self-propulsion originates from a gradient of mechanical stress, in a way similar to the Marangoni effect. This stress is not localized at the edge but distributed within the whole droplet. We compare our findings with the experimental observations and other theoretical results.

Cyclobutane pyrimidine dimers (CpDs) are among the most common DNA lesions occurring due to the interaction with ultraviolet light. While photolyases have been well known as external factors repairing CpDs, the intrinsic self-repairing capabilities of the GAT[double bond, length as m-dash]T DNA sequence were discovered only recently and are still largely obscure. Here, we elucidate the mechanistic details of this self-repair process by means of MD simulations and QM/MM computations involving the algebraic diagrammatic construction to the second order [ADC(2)] method. We show that local UV-excitation of guanine may be followed by up to three subsequent electron transfers, which may eventually enable efficient CpD ring opening when the negative charge resides on the T[double bond, length as m-dash]T dimer. Consequently, the molecular mechanism of GAT[double bond, length as m-dash]T self-repair can be envisaged as sequential electron transfer (SET) occurring downhill along the slope of the S1 potential energy surface. Even though the general features of the SET mechanism are retained in both of the studied stacked conformers, our optimizations of different S1/S0 state crossings revealed minor differences which could influence their self-repair efficiencies. We expect that such assessment of the availability and efficiency of the SET process in other DNA oligomers could hint towards other sequences exhibiting similar photochemical properties. Such explorations will be particularly fascinating in the context of the origins of biomolecules on Earth, owing to the lack of external repairing factors in the Archean age.

The 15-copper(ii)-containing 36-tungsto-4-silicates [Cu15O2(OH)10X(A-α-SiW9O34)4]25- (X = Cl, 1; Br, 2) have been prepared in 70% yield by reaction of the trilacunary 9-tungstosilicate precursor [A-α-SiW9O34]10- with Cu2+ ions in aqueous pH 8 medium. Both polyanions 1 and 2 were isolated as hydrated mixed potassium/sodium salts and characterized in the solid state by FT-IR, TGA, single-crystal XRD, and elemental analysis. DC magnetic susceptibility measurements from 1.8-300 K established the ground state to be paramagnetic with a magnetic moment corresponding to 15 uncoupled Cu2+ (S = 1/2) ions. EPR measurements and simulations were consistent with this analysis. Electrochemical studies were performed for polyanions 1 and 2 dissolved in solution to elucidate the electroactivity of both copper and tungstate sites. Using 2 as a representative example, the electrocatalytic activity towards CO2 reduction upon deposition on a glassy carbon electrode surface, while retaining selectivity relative to hydrogen evolution, was demonstrated.

Artykuł nie zawiera streszczenia w języku polskim.

The role that civil society plays in protection of historic monuments and sites is defined in Polish strategic documents. No procedures for cooperating with historic preservation officers have been, however, established. This article looks at an organisation named “Social Guardians of Monuments and Sites” and says why it is necessary to use its services in view of the existing system being inefficient. Additionally, it also explains reasons behind this inefficiency and explores various cooperation possibilities. Moreover, the article points out that even when the services responsible for protection of monuments and sites are reformed, cooperation with the above-mentioned organisation will be still needed and justified. This results not only from considerable disproportion between responsibilities and possibilities of both institutions but also from effectiveness of the government body being questionable. Furthermore, the structure of historic preservation services should be based on cooperation requirements - it should be simple, clear, and should allow for using already gained experience.

Capital punishment is an exceptional type of penal sanction for the most serious crimes in penal legislation of countries which permit such penalty. In the period of the Second Polish Republic a capital punishment judgement in military penal law was permitted for crimes committed at the time of war, often having negative impact on the combat capacity and morale of a given military unit. Following the example of legislation of the Second Polish Republic, authors of the Polish Army’s Penal Code from 1944 assumed that a capital punishment judgement should apply to extremely serious crimes committed by soldiers, usually “in the field”, in the course of war operations. Inclusion of a chapter concerning political crimes punishable with serious penal sanctions (including capital punishment) into the military code of 1944, as well as moving civil cases of people accused of such acts under the jurisdiction of military courts, led to a situation where this code (in judiciary practice since the beginnings of the Polish People’s Republic) became one of the most repressive legal acts, taking into account the number of death penalties adjudged under its provisions.

In a previous paper [6] the Bergman projection in D = A ∪ B, the union of domains A, B ⊂ CN, was described by alternating projections procedure. It was shown that when N = 1, and A, B are two halfplanes, the procedure can be carried out by explicit analytic calculations. In the present paper we show that the same is true for A = {|Re z| < π} and B = {Re z > 0}. In this case the calculations are more involved, and an essential use is made of L2-theorems of Paley–Wiener type due to T. Genchev, M. Dzrbasjan and W. Martirosjan. Of central importance is an operator W which maps f(z) onto . We show that for every g ∈ L2H(B) the sequence Wng (n = 1, 2, …) converges to zero locally uniformly in B.