World Institute on Disability

This article documents a disability-inclusive study conducted in partnership with disabilityled -community-based organizations in survey development and distribution. Information collection focused on the lived experiences of people with disabilities, their perceived impact, and their future expectations. Survey results from 413 individuals with disabilities document the disaster or personal crisis-related experiences and their subsequent impacts. Results from a selection of survey questions were identified for further exploration and their potential impact on disability-inclusive planning, response, and recovery, with a view to identifying potential variables that impact the disproportionate impact of disasters on people with disabilities. Perspectives provided by survey respondents, who were exclusively people with disabilities, overlapped with but did not necessarily align with what is known about emergency and disaster response systems. Study outcomes supported current recommended practices for inclusive planning with people with disabilities. The study supports the premise that accessibility, programmatic inclusion, and effective communication impact the lived experience of people with disabilities in disasters and warrant additional inquiry. Furthermore, the equitable and valued involvement of people with disabilities and disabilityled organizations is essential in disaster research, policy, and practice that does not leave anyone behind. Research can, and should, be conducted in coordination with disability stakeholders and people with disabilities in order to generate useful and implementable policy and practice information. This inclusive approach should take priority over rigorous academic research methods and standards for principled and practical -considerations.

This deliverable is aimed to compile the datasets that have been generated in the context of the work done by WP2. In addition to this, the source code to replicate the CS Track database is reported as well in this deliverable, mainly because this database has been used as the main source to generate the corresponding datasets. The details regarding the research conducted in the associated studies are fully documented in D2.2. This deliverable only contains a summary of the corresponding study in order to frame the purpose and relatedness of the dataset. In addition to this, for each dataset it is briefly described the content and its grouping (how data is organised). Each dataset corresponds to different nature of research, this means its content will differ among them.

Giant cell arteritis (GCA) is a challenging condition to manage because of the potential for acute irreversible vision loss and corticosteroid-related morbidity. Recent developments offer the potential to improve both the assessment and treatment of patients. Vascular imaging is increasingly being used in the diagnostic algorithm for GCA. Results from recent vascular ultrasound and high-resolution cranial MRI studies have led some groups to suggest forgoing temporal artery biopsy (TAB) in selected patients. The treatment armamentarium has been enhanced with the addition of Tocilizumab, a monoclonal antibody that inhibits IL-6 and has been shown to be effective in sustaining glucocorticoid-free remission out to 52 weeks. New publications have provided guidance in how clinicians can interpret minimally inflamed biopsies and navigate the controversy about what role, if any, varicella zoster virus may play in the pathophysiology of GCA. Basic science developments have improved our understanding of the immunopathology of GCA including the role of Th1 and Th17 lymphocytes and mechanisms of arterial wall lymphocyte invasion. There have been significant recent advances in GCA, particularly in relation to imaging and treatment options. Longer term outcome data will help clarify how best to utilize them in routine clinical practice.

The habenular complex in the epithalamus consists of distinct regions with diverse neuronal populations. Past studies have suggested a role for the habenula in voluntary exercise motivation and reinforcement of intracranial self-stimulation but have not assigned these effects to specific habenula subnuclei. Here, we have developed a genetic model in which neurons of the dorsal medial habenula (dMHb) are developmentally eliminated, via tissue-specific deletion of the transcription factor Pou4f1 (Brn3a). Mice with dMHb lesions perform poorly in motivation-based locomotor behaviors, such as voluntary wheel running and the accelerating rotarod, but show only minor abnormalities in gait and balance and exhibit normal levels of basal locomotion. These mice also show deficits in sucrose preference, but not in the forced swim test, two measures of depression-related phenotypes in rodents. We have also used Cre recombinase-mediated expression of channelrhodopsin-2 and halorhodopsin to activate dMHb neurons or silence their output in freely moving mice, respectively. Optical activation of the dMHb in vivo supports intracranial self-stimulation, showing that dMHb activity is intrinsically reinforcing, whereas optical silencing of dMHb outputs is aversive. Together, our findings demonstrate that the dMHb is involved in exercise motivation and the regulation of hedonic state, and is part of an intrinsic reinforcement circuit.

Abstract Purpose To investigate the distribution and expression of macrophage phenotypes and the complement activation protein, C3d, in human choroid/retina in young, aged and AMD eyes.Methods Paraffin sections of central and peripheral choroid/retina from young (<40 years, n=6), aged (>70 years, n=4) and AMD (>70 years, n=8) human post‐mortem eyes were co‐immunolabelled with antibodies to leukocyte and macrophage markers (CD68, CD163, Iba1 & CD45) and complement activation component, C3d. Localisation and distribution of antibodies was assessed using confocal microscopy. Counts of macrophage sub‐populations were compared in central and peripheral choroid for each group.Results Heterogeneous populations of macrophages were found in the choroid/retina of all groups. Iba1+ and CD45+ retinal microglia and macrophages, and choroidal macrophages were observed in all eyes. In AMD eyes, Iba1+ and CD45+ cells were seen in the subretinal space amongst photoreceptors, as well as in inner retina. Compared to young eyes, aged and AMD specimens showed increased numbers of CD163+ macrophages (M2, proangiogenic) in choroid, and in central vs peripheral retina. Fewer CD68+ cells were seen in all specimens, regardless of age or location. C3d was expressed in young, aged and AMD eyes, localised to Bruch’s membrane and choriocapillaris, with more extensive immunostaining in aged and AMD eyes. C3d was also seen in drusen in aged and AMD eyes, and more peripherally, compared to young eyes.Conclusion Age‐related changes in macrophage phenotypes and in complement pathway activation at the choroidal/retinal interface may play a role in development and progression of AMD. Supported by Sydney Foundation for Medical Research.

Mathematical Biology Get access Introduction to Mathematical Biology, by Rubinow S. I.. John Wiley & Sons, New York, 1975, 386 p., illus., $22.00 (75-12520). William J. Hirschfeld William J. Hirschfeld Illinois Institute for Developmental Disabilities, 1640 West Roosevelt Road, Chicago, IL 60608 Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 26, Issue 10, October 1976, Page 638, https://doi.org/10.2307/1297203 Published: 01 October 1976