Wuhan National Laboratory for Optoelectronics

Selective recognition of cancer-associated proteins (CAPs) by antibodies, followed by their delivery into the intracellular organelle, the lysosome, results in targeted degradation of CAPs and suppresses the growth of cancer cells. Translocating the antibody-CAP complex across the plasma membrane is, however, nontrivial. Phase-separating molecules are known to form membrane-translocating coacervates that can encapsulate proteins and transport them into the cytoplasm. Nevertheless, these coacervates generally lack the ability to guide the cargo to the lysosome. Here, we seal this gap and develop lysosome-targeting coacervates by tailoring a tetrapeptide into a phase-separating, coacervate-forming peptide. In the aqueous solution, the peptide derivative forms microdroplets, or coacervates, through liquid-liquid phase separation (LLPS), which spontaneously enter cells and colocalize with the lysosome; hence, these coacervates are referred to as Lysosome-Sorting Peptide Coacervates or LSP-Coa. We show that LSP-Coa can encapsulate proteins, facilitate the translocation of antibody-CAP complexes to the lysosome, and enable the degradation of membrane-bound CAPs - a mechanism we call Coacervate-mediated Lysosome-targeting Protein Degradation, or CoaLPD. Using the CoaLPD technology, we successfully degraded HER2 and EGFR in cancer cells and in tumor-bearing mice, showcasing its potential use as an anticancer treatment. The LSP-Coa system also increases the efficacy of PROTAC degradation through enhanced lysosomal uptake. Taken together, we present the design of lysosomal-targeting coacervates and demonstrate their use as vehicles for lysosome-specific antibody delivery and for the selective degradation of CAPs, thereby validating the CoaLPD strategy as a potential anticancer treatment.

The high voltage power supply system for the pulsed high magnetic field facility at the Wuhan National High Magnetic Field Center (WHMFC) will be upgraded to a 167 MJ capacitor bank system comprising 73 modules. This system will serve 27 magnet experimental stations over the next five years. The capacitor bank system is located on the second floor of the Pulsed Building, while all experimental stations occupy the first floor; each floor covers approximately 2000 square meters. The 27 experimental stations are divided into four independent zones. Each zone is supplied by dedicated capacitor bank modules and features an independent grounding system. This configuration ensures that operators in unaffected zones are not exposed to hazards during high voltage or high magnetic field experiments conducted in another zone, requiring evacuation only from stations within the active zone. Consequently, this design significantly improves experimental efficiency and greatly enhances overall facility utilization.

Emerging demands for dynamic wavefront modulation in holographic displays, augmented/virtual reality, and light detection and ranging require spatial light modulators (SLMs) with high pixel density and fast refresh rates. However, key parameters of existing liquid-crystal and metasurface-based SLMs, such as spatiotemporal product density, field of view and refresh rate, remain far below application requirements. Here we report an optically addressed metasurface SLM composed of independently tunable meta-atom supercells with a 756 nm pitch. This device reduces SLM pixel size to the submicrometre scale while achieving a spatiotemporal product density of 2.3 × 1012 pixels s-1 cm-2, thereby meeting the critical threshold for true holography. It enables real-time complex-amplitude holography, three-dimensional focusing and beam steering over a ±20.6° field of view in the visible spectrum.

Abstract Monolayer WSi2N4 has been predicted to be a high-performance p-type semiconductor with high hole mobility, high on-state current density, high strength, and high thermal conductivity. Achieving large-area growth of monolayer WSi2N4 with controlled doping is a prerequisite for the scalable integration of device applications. However, only micrometer-sized monolayer WSi2N4 domains have been synthesized so far. Here, we report the growth of wafer-scale monolayer WSi2N4 films with submillimeter domains by chemical vapor deposition using a liquid Au/W bilayer as the growth substrate, with a growth rate three orders of magnitude higher than previously reported values. This method also enables efficient modulation of carrier doping concentration from 5.8 × 1012 cm−2 to 3.2 × 1013 cm−2 through in-situ defect engineering. This doping-tunable monolayer WSi2N4 exhibits p-type semiconducting characteristics with a bandgap of ~2.25 eV, achieving an on/off current ratio of 5.4 × 104 at low doping level and a high on-state current density (~150 μA μm−1) and a low contact resistance (0.95 kΩ μm) for heavily-doped material. Moreover, it has excellent stability and ultrahigh Young’s modulus (~538 GPa) and strength (~62 GPa). This work paves the way for the applications of monolayer WSi2N4 as a promising p-type channel material in 2D complementary metal-oxide-semiconductor integrated circuits.